A study of the archaeology of Caucasian Iberia with implications for grazing management in Australia. This multi-disciplinary project will promote a younger generation of talented postgraduate and undergraduate students in a wide variety of fields, including archaeology, geomatic engineering, conservation of material culture, environmental and other natural sciences. The highlands of the Caucasus, located in a bioclimatic zone with a long history of alpine grazing, can also provide answers to qu ....A study of the archaeology of Caucasian Iberia with implications for grazing management in Australia. This multi-disciplinary project will promote a younger generation of talented postgraduate and undergraduate students in a wide variety of fields, including archaeology, geomatic engineering, conservation of material culture, environmental and other natural sciences. The highlands of the Caucasus, located in a bioclimatic zone with a long history of alpine grazing, can also provide answers to questions such as the effect of grazing on biodiversity and the rehabilitation of fragile ecosystems, which may inform management and conservation activities in analogous highland country in Australia. The project will also ensure that exhibitions illustrating the rich heritage of Caucasus will reach Australian shores.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100620
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
Inference, control and protection of interdependent spatial networked structures. Networked structures are everywhere and modern societies largely depend on their proper functioning. Some of these networks are spatial with each node having a geographical tag. Examples include power grids, the internet and transportation networks. These networks are often interdependent where their functioning depends on each other. This project will establish a mathematical framework to efficiently observe and c ....Inference, control and protection of interdependent spatial networked structures. Networked structures are everywhere and modern societies largely depend on their proper functioning. Some of these networks are spatial with each node having a geographical tag. Examples include power grids, the internet and transportation networks. These networks are often interdependent where their functioning depends on each other. This project will establish a mathematical framework to efficiently observe and control interdependent spatial networks and develop design strategies in order to maximise residency of spatial networks against catastrophic failures in their components. The outcomes of the project will protect the Australian power grid and transportation networks against random and intentional failures. Read moreRead less
Networks: New links between spectrum, dynamics, rewirings and applications. Modern network science has transformed the study of complex systems and led to innovations in many disciplines. This project intends to develop breakthrough theories for control of complex networked system behaviour via interventions of the link-rewiring type. New approaches will be developed for non-random, assortative and/or structured networks, which are poorly understood and difficult to deal with, despite being the ....Networks: New links between spectrum, dynamics, rewirings and applications. Modern network science has transformed the study of complex systems and led to innovations in many disciplines. This project intends to develop breakthrough theories for control of complex networked system behaviour via interventions of the link-rewiring type. New approaches will be developed for non-random, assortative and/or structured networks, which are poorly understood and difficult to deal with, despite being the real-world norm and despite their impact. The results will give new insights into epidemic outbreaks and their impact on vulnerable groups (e.g., elderly and indigenous), and provides methods to enforce resilience of infrastructure networks such as power grids, thereby providing significant economic and societal benefits. Read moreRead less
Variable Structure Complex Network Systems with Smart Grid Applications. This project aims to establish a breakthrough theory and technology to help deliver reliability and security of complex network systems, which are subject to structure changes, against faults and cyberattacks. Expected outcomes include a new theory that lays the foundation for understanding such systems, innovative algorithms and tools for their design, and a practical software platform used for ensuring reliability and sec ....Variable Structure Complex Network Systems with Smart Grid Applications. This project aims to establish a breakthrough theory and technology to help deliver reliability and security of complex network systems, which are subject to structure changes, against faults and cyberattacks. Expected outcomes include a new theory that lays the foundation for understanding such systems, innovative algorithms and tools for their design, and a practical software platform used for ensuring reliability and security of such systems. It will be applied directly to critical infrastructure such as the national power grid to help maintain lifeline resilience and achieve economic benefits. It will also provide an opportunity to train the next generation engineers in this cutting-edge technology for Australia.Read moreRead less
The Role Of Non-classical MHC Class I Molecules In Adaptive Immunity
Funder
National Health and Medical Research Council
Funding Amount
$443,834.00
Summary
Specialised proteins called MHC class Ia molecules (MHC-Ia) stimulate killer T cells to lyse virus infected cells. In contrast, the function of the closely related MHC-Ib is uncertain. Recent findings have demonstrated that MHC-Ib can also be recognised by T cells and this interaction is important in the control of viral infections. However, despite the similarity to MHC-Ia, it is unclear how this interaction occurs. This project aims to investigate how killer T cells recognise MHC-Ib molecules.
Engineering evolving complex network systems through structure intervention. This project aims to create a theory and technology for engineering complex network systems (CSS) through structural intervention. Complex network systems with evolving components are ubiquitous in nature and society. The science of biological networks, the Internet and large-scale power networks demand tools to understand and influence their evolving dynamics. This project could result in a breakthrough theory in netwo ....Engineering evolving complex network systems through structure intervention. This project aims to create a theory and technology for engineering complex network systems (CSS) through structural intervention. Complex network systems with evolving components are ubiquitous in nature and society. The science of biological networks, the Internet and large-scale power networks demand tools to understand and influence their evolving dynamics. This project could result in a breakthrough theory in network science and technology to augment biological systems and power grids. Expected benefits include cost-effective augmentation of power networks injected with renewable energy sources, and advancing basic biology research.Read moreRead less
Congestion control in complex networks with higher-order interactions. Traffic congestion significantly costs the Australian economy and environment. This project aims to develop ground-breaking network models of urban traffic systems to build a new congestion control framework. The purpose of network modelling is to capture the interdependence between different parts of traffic systems, which facilitates studying congestion cascade within the network. The project expects to generate next genera ....Congestion control in complex networks with higher-order interactions. Traffic congestion significantly costs the Australian economy and environment. This project aims to develop ground-breaking network models of urban traffic systems to build a new congestion control framework. The purpose of network modelling is to capture the interdependence between different parts of traffic systems, which facilitates studying congestion cascade within the network. The project expects to generate next generation of network models for more effective congestion control. Expected outcomes include novel congestion control technologies that adjust traffic signals in real-time to optimally utilise the available road space. This should provide significant economic and environmental benefits to Australians by easing traffic jams.Read moreRead less
Dhenia: A study of regionalism, population and society in Bronze Age Cyprus. The cemetery complex at Dhenia in Cyprus was in use for 2500 years, from the beginning of the Bronze Age (2,400 BCE) to the end of the Iron Age. This project is designed to sample this extensive site to assess its changing size and structure during periods of major social transformation. Comparative studies of contemporary sites will provide the basis for monitoring and explaining local, regional and island-wide relatio ....Dhenia: A study of regionalism, population and society in Bronze Age Cyprus. The cemetery complex at Dhenia in Cyprus was in use for 2500 years, from the beginning of the Bronze Age (2,400 BCE) to the end of the Iron Age. This project is designed to sample this extensive site to assess its changing size and structure during periods of major social transformation. Comparative studies of contemporary sites will provide the basis for monitoring and explaining local, regional and island-wide relationships, viewed in a context of expanding population and increasing interaction with the wider Mediterranean world. New data and approaches will contribute significantly to Cypriot archaeology and to broader archaeological theory.Read moreRead less
Dynamics and Resilience of Complex Network Systems with Switching Topology . This project aims to develop a breakthrough methodology and new technology to analyse and integrate large-scale network systems, such as power grids, that involve large networks of components with switching connections. The project expects to create a new theoretical framework to tackle the challenges arising from switching topology resulted from switching connections, and methods to understand their behaviours and desi ....Dynamics and Resilience of Complex Network Systems with Switching Topology . This project aims to develop a breakthrough methodology and new technology to analyse and integrate large-scale network systems, such as power grids, that involve large networks of components with switching connections. The project expects to create a new theoretical framework to tackle the challenges arising from switching topology resulted from switching connections, and methods to understand their behaviours and design intervention strategies to achieve optimal outcomes. The expected outcome is a practical technology for industry applications, such as smart power grids. This should increase the reliability and resilience of the electricity networks against faults and cyber attacks.
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Structural Studies On The Immune Effector Perforin: Developing Mechanism-based Inhibitors
Funder
National Health and Medical Research Council
Funding Amount
$1,116,594.00
Summary
Perforin is an essential weapon deployed by the human immune cells in order to destroy virally infected or cancerous cells. Despite this key role, unwanted or excessive perforin function can result in disease and can severely impact on successful treatment of leukaemia through bone marrow transplantation. This application aims to understand the molecular details of perforin function, and to apply this knowledge to develop perforin inhibitors.