The Unique Nature Of Gamma Delta T Cell Recognition Resolved Through Interaction With H2-Q10
Funder
National Health and Medical Research Council
Funding Amount
$699,031.00
Summary
The liver is important for both digestion and immunity. Given these opposing functions, the liver must exert control points that prevent the immune system from recognising food products. We have now identified a new molecular target that controls the development of immune cells in the liver.
Structural And Functional Characterisation Of The Killer Cell Immunoglobulin-like Receptor (KIR) Family Of Natural Killer Cell Receptors
Funder
National Health and Medical Research Council
Funding Amount
$348,070.00
Summary
Natural Killer (NK) cells are an important component of the immune response to cancer and infection. This project will define the molecular targets that are recognised by NK cells. This knowledge can then be used to guide in the selection of bone marrow donors in the treatment of leukemias as well as understanding how we fight off infections.
The innate immune response is our primary defence against infection, but must be controlled carefully to avoid chronic inflammation and autoimmunity. Studying tiny regulators of gene function called micro-RNAs and unique cellular pathways, we aim to understand the “big picture” of genetic regulatory systems in innate immunity to provide new insights into inflammation and infection, the genetic basis of diseases, and to identify new potential therapeutic targets, biomarkers and antiviral targets.
A Systems-biology Approach To Understanding The Beneficial Heterologous Effects Of Neonatal BCG Vaccination In A Melbourne-based Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$846,853.00
Summary
BCG vaccine (usually used to protect against TB) also enhances the immune system of young babies to protect them against infections other than TB. We have a large collection of blood samples from a study in which babies were randomised to be given BCG vaccine at birth or no BCG. We will use these to understand the immunological and molecular mechanisms by which BCG boosts the immune system to protect against infections other than TB.