TSuNAMi: Time Series Network Animal Modelling. Our proposal is motivated by and based upon the successful representation of time series as a network (or graph). We construct an abstract representation of a system from measurements of its changing behaviour over time. Properties of that structure (the network) then allow us to infer diagnostic information of the system. Specifically, we propose to apply this to livestock welfare during transport. By measuring the biological and environment condi ....TSuNAMi: Time Series Network Animal Modelling. Our proposal is motivated by and based upon the successful representation of time series as a network (or graph). We construct an abstract representation of a system from measurements of its changing behaviour over time. Properties of that structure (the network) then allow us to infer diagnostic information of the system. Specifically, we propose to apply this to livestock welfare during transport. By measuring the biological and environment condition of the animal we construct a network representation of that system. Geometric features of that network can then be used to infer health or duress of the subject. This proposal will develop the generic mathematical machinery to connect geometric features of the network with system behaviour. Read moreRead less
Complex dynamical systems: inferring form and function of interacting biological systems. Often in biology a large number of simple parts interacting according to simple rules can result in behaviour that is rich and varied. This project aims to develop the mathematics of complex systems theory to describe how such collections of simple interacting parts can form large complicated structures, and to deduce what dynamical behaviour can result.
Quantifying complexity and measuring structure within complex systems. Most interesting systems are complex. The complex systems of interest in this project are characterised by a simple dynamical behaviour on each individual part; and a complicated web of interaction between the many distinct parts. The project will focus on the massive system of interacting neurones in the brain, and transmission of influenza via interpersonal contacts. This project will provide a better model of that web of i ....Quantifying complexity and measuring structure within complex systems. Most interesting systems are complex. The complex systems of interest in this project are characterised by a simple dynamical behaviour on each individual part; and a complicated web of interaction between the many distinct parts. The project will focus on the massive system of interacting neurones in the brain, and transmission of influenza via interpersonal contacts. This project will provide a better model of that web of interactions; and new methods for statistically validating this model against data. Existing models of complex networks are statistically biased so, by employing robust statistical methodologies, this problem will be rectified and provide a method for randomly choosing representative complex systems. Read moreRead less
Navigating tipping points in complex dynamical systems. This project aims to use applied mathematics to investigate the onset of tipping points in dynamical systems. Working with clinicians and practicing engineers, the project aims to contribute to the development of new treatment regimes for dynamical diseases and develop improved management strategies for resource focussed engineering industries. This should provide significant benefit to many areas, including the personalised treatment of di ....Navigating tipping points in complex dynamical systems. This project aims to use applied mathematics to investigate the onset of tipping points in dynamical systems. Working with clinicians and practicing engineers, the project aims to contribute to the development of new treatment regimes for dynamical diseases and develop improved management strategies for resource focussed engineering industries. This should provide significant benefit to many areas, including the personalised treatment of disease.Read moreRead less
Novel Statistical Methods For Genetic Epidemiology
Funder
National Health and Medical Research Council
Funding Amount
$481,505.00
Summary
We are in the midst of a genomics revolution that is transforming epidemiology, medicine and drug discovery. However, the scarcity of sophisticated statistical techniques to deal with the complicated problems inherent in genetic investigations of complex diseases is currently the critical factor limiting the success of human gene discovery programs. Statistical genetic methodology is currently one of the fastest developing areas of epidemiology. In information-intensive' areas such as genetic ep ....We are in the midst of a genomics revolution that is transforming epidemiology, medicine and drug discovery. However, the scarcity of sophisticated statistical techniques to deal with the complicated problems inherent in genetic investigations of complex diseases is currently the critical factor limiting the success of human gene discovery programs. Statistical genetic methodology is currently one of the fastest developing areas of epidemiology. In information-intensive' areas such as genetic epidemiology, genomics, and proteomics, there is a high demand for data analysis and statistical skills. WA has some world class expertise in statistical science, both in academia and in industry. However, this expertise has not yet been applied in a system way to genetic data analysis. We propose to undertake advanced methodological research in statistical genetics and bioinformatics, to produce easy-to-use and accessible software tools and resources that allow methodological advances to be accessed by the Australian research community, and to apply our new methods and tools both to specific disease research and to the developing human genome epidemiology (HuGE) enterprise in WA. These new initiatives in methodological research will draw together a number of currently separate research strands and will provide new tools and resources that will allow applied Australian programs to improve the efficiency of their research into the causes of important. Methodological development in both bioinformatics and statistical genetics are recognized international areas of need.Read moreRead less
Extending the spectrum and performance of ultra-stable frequency generation. Precision oscillators developed at the University of Western Australia have application in telecommunications, advanced radar, optical to microwave links, frequency and time standards, VLBI, tests of fundamental physics etc., and have attracted worldwide interest. This project will strengthen Australian 'know how' and extend our expertise into new frequency bands essential for space communications and high frequency rad ....Extending the spectrum and performance of ultra-stable frequency generation. Precision oscillators developed at the University of Western Australia have application in telecommunications, advanced radar, optical to microwave links, frequency and time standards, VLBI, tests of fundamental physics etc., and have attracted worldwide interest. This project will strengthen Australian 'know how' and extend our expertise into new frequency bands essential for space communications and high frequency radio Astronomy. This will include necessary international collaboration with world elite institutes.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL0992016
Funder
Australian Research Council
Funding Amount
$2,064,351.00
Summary
Frontiers of Precision Time and Frequency. Devices for precise frequency and time metrology invented at the University of Western Australia have application in telecommunications, advanced radar, optical to microwave links, frequency and time standards, astronomy, tests of fundamental physics and have attracted worldwide interest. This project will strengthen Australian "know how" and expertise, and place us in a position to participate in current and future space missions. Moreover, this repres ....Frontiers of Precision Time and Frequency. Devices for precise frequency and time metrology invented at the University of Western Australia have application in telecommunications, advanced radar, optical to microwave links, frequency and time standards, astronomy, tests of fundamental physics and have attracted worldwide interest. This project will strengthen Australian "know how" and expertise, and place us in a position to participate in current and future space missions. Moreover, this represents an opportunity for high profile involvement as the only southern hemisphere user of the most accurate space clock ever developed, which will likely involve the order of 30 institutes worldwide. This work necessarily includes collaboration with the world's elite metrological institutes.Read moreRead less
Developing New Clocks for Australia: Testing the Assumptions of Modern Physics. Clocks lie at the heart of all precise measurement devices; for example, they are the crucial elements in modern navigation and telecommunications systems. This project will develop three new clocks for Australia: a laser clock at the leading edge of technology, a novel and compact clock with commercial potential, and a microwave clock for use in the next generation of satellites. The performance advantage conferre ....Developing New Clocks for Australia: Testing the Assumptions of Modern Physics. Clocks lie at the heart of all precise measurement devices; for example, they are the crucial elements in modern navigation and telecommunications systems. This project will develop three new clocks for Australia: a laser clock at the leading edge of technology, a novel and compact clock with commercial potential, and a microwave clock for use in the next generation of satellites. The performance advantage conferred by our new devices can deliver economic benefits while also giving the possibility for scrutinizing the laws of physics for evidence that there is something beyond our present formulation.Read moreRead less
A Structural Investigation Into The T-cell Response To Epstein Barr Virus Infection
Funder
National Health and Medical Research Council
Funding Amount
$549,000.00
Summary
X-ray crystallography is an essential tool for solving the three-dimensional structure of proteins. Proteins control the biological processes within the cell and it is the precise shape of proteins that determines how they function. Depending on the particular sequence of the amino acids, the so-called building unit of the proteins, the protein molecule bends and forms a distinct, complex shape. This specific three-dimensional shape allows the protein to undertake its specific function, such as ....X-ray crystallography is an essential tool for solving the three-dimensional structure of proteins. Proteins control the biological processes within the cell and it is the precise shape of proteins that determines how they function. Depending on the particular sequence of the amino acids, the so-called building unit of the proteins, the protein molecule bends and forms a distinct, complex shape. This specific three-dimensional shape allows the protein to undertake its specific function, such as binding to other proteins, acting as an enzyme or interacting with nucleic acids. To determine how a protein acts, it is vital to know the precise three-dimensional shape at the atomic level. This proposal is concerned with understanding the precise shape of proteins that control the immune response to Epstein Barr Virus. Epstein Barr Virus is an ubiquitous human pathogen that has being linked to a number of cancers. This work will further our understanding of the immune response to Epstein Barr Virus.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775668
Funder
Australian Research Council
Funding Amount
$210,000.00
Summary
Direct write - microphotonics fabrication facility. Direct write-microfabrication, where an ultrafast laser is focussed to a small, intense spot and translated under computer control with respect to a target sample, has emerged as a significant enabling technology creating new opportunities in microphotonics. The proposed facility will enable researchers to modify the internal properties of glass blocks and write 'optical wires' (or waveguides). By combining waveguides with other laser written f ....Direct write - microphotonics fabrication facility. Direct write-microfabrication, where an ultrafast laser is focussed to a small, intense spot and translated under computer control with respect to a target sample, has emerged as a significant enabling technology creating new opportunities in microphotonics. The proposed facility will enable researchers to modify the internal properties of glass blocks and write 'optical wires' (or waveguides). By combining waveguides with other laser written functional components researchers will develop devices capable of processing optical information. Outcomes will include demonstrations of compact lasers and slow light generation.Read moreRead less