The Unique Nature Of Gamma Delta T Cell Recognition Resolved Through Interaction With H2-Q10
Funder
National Health and Medical Research Council
Funding Amount
$699,031.00
Summary
The liver is important for both digestion and immunity. Given these opposing functions, the liver must exert control points that prevent the immune system from recognising food products. We have now identified a new molecular target that controls the development of immune cells in the liver.
The canonical stratification of jet spaces. Singularities occur everywhere in nature, from the formation and collapse of stars to the morphology of living embryos. They appear whenever the geometry of surfaces or spaces undergoes a process of twisting, folding, or collapsing on itself. Singularity Theory is the study of such phenomena, an important branch of modern mathematics which has close connections with many other branches of mathematics and applied sciences. Singularity Theory lies at the ....The canonical stratification of jet spaces. Singularities occur everywhere in nature, from the formation and collapse of stars to the morphology of living embryos. They appear whenever the geometry of surfaces or spaces undergoes a process of twisting, folding, or collapsing on itself. Singularity Theory is the study of such phenomena, an important branch of modern mathematics which has close connections with many other branches of mathematics and applied sciences. Singularity Theory lies at the crossroads of the paths connecting the most important areas of applications of mathematics with its most abstract parts. Analytic Singularity Theory is a central part of Singularity Theory. This project would lead to substantially new advancements in Analytic Singularity Theory.Read moreRead less
Early settlements in Upper Burma (Myanmar): an experiment in urban living. This project directly increases access for Australian research to a previously self-isolated nation, Myanmar. It contributes to better understanding of our region and our world by examining how past communities worked together and how they dealt with social and environmental stress.
Chorasmian temples: an archaeological study of early Zoroastrianism and its precursors in Central Asia. The project is a collaboration with the Uzbek Academy of Sciences. National benefits to Australia are in international relations and in broadening our understanding of cultural issues in the potentially volatile and politically significant region of Central Asia. The team has developed a high profile in Uzbekistan and internationally, reflecting well on Australia's cultural strengths, intern ....Chorasmian temples: an archaeological study of early Zoroastrianism and its precursors in Central Asia. The project is a collaboration with the Uzbek Academy of Sciences. National benefits to Australia are in international relations and in broadening our understanding of cultural issues in the potentially volatile and politically significant region of Central Asia. The team has developed a high profile in Uzbekistan and internationally, reflecting well on Australia's cultural strengths, international involvement and support for developing countries in Asia. Our research features regularly in the Uzbek media and has the personal approval of President Karimov. We are involved with Zoroastrian and Parsi communities in Australia and overseas, particularly in India and the USA, and our results are published regularly in the community press.Read moreRead less
East meets West: an archaeological study of early contact between China and Eurasia. The project will link Chinese and Australian researchers in a collaborative programme exploring the origins of cultural contact between China and the West. Through the work of a team of international specialists, this fresh initiative will bring western analytical techniques together with Chinese archaeological experience to create a new and robust picture of the evidence for early cultural contact. From this we ....East meets West: an archaeological study of early contact between China and Eurasia. The project will link Chinese and Australian researchers in a collaborative programme exploring the origins of cultural contact between China and the West. Through the work of a team of international specialists, this fresh initiative will bring western analytical techniques together with Chinese archaeological experience to create a new and robust picture of the evidence for early cultural contact. From this we will study the early movements of Indo-European populations and examine the question of the origins of early metal production in China.Read moreRead less
With or without pots: Investigating the archaeology of human settlement on Santa Isabel, western Solomon Islands. Following the recent civil unrest in the Solomon Islands, the SI National and Provincial Governments, as well as community bodies, have identified a better understanding of the past and the revival of traditional systems and knowledge (Kastom) as a route to stability and cohesion throughout the region. This study responds to direct requests from the Santa Isabel community for assist ....With or without pots: Investigating the archaeology of human settlement on Santa Isabel, western Solomon Islands. Following the recent civil unrest in the Solomon Islands, the SI National and Provincial Governments, as well as community bodies, have identified a better understanding of the past and the revival of traditional systems and knowledge (Kastom) as a route to stability and cohesion throughout the region. This study responds to direct requests from the Santa Isabel community for assistance with archaeological research and the recording of cultural histories. By assisting a Pacific neighbour to develop a more durable, internally generated basis for social and economic development, Australia not only encourages security in the region, but also increases its engagment with and understanding of adjacent cultures.Read moreRead less
The biology and epidemiology of the grapevine canker fungi, Botryosphaeria sp. Decline and dieback of grapevines is becoming an increasing problem for the viticulture industry in NSW. Recently, species of the fungus Botryosphaeria, were isolated from grapevines exhibiting these symptoms. In order to understand the biology and epidemiology of the causal organisms, we aim to; (i) determine species of Botryosphaeria present in NSW vineyards; (ii) determine which species are pathogenic on grapevines ....The biology and epidemiology of the grapevine canker fungi, Botryosphaeria sp. Decline and dieback of grapevines is becoming an increasing problem for the viticulture industry in NSW. Recently, species of the fungus Botryosphaeria, were isolated from grapevines exhibiting these symptoms. In order to understand the biology and epidemiology of the causal organisms, we aim to; (i) determine species of Botryosphaeria present in NSW vineyards; (ii) determine which species are pathogenic on grapevines; (iii) characterise the genetic diversity of strains and; (iv) screen fungicides for the control of these fungi. Information on the species, their biology and pathogenicity on grapevines, will enable the development of appropriate management strategies for its control and may lead to the development of molecular tools to identify species of Botryosphaeria.Read moreRead less
Elam in the 2nd millennium B.C.: A multi-regional approach. Although it was one of the Near East's most powerful ancient states, Elam has received less scholarly attention than its neighbours. Using an innovative approach targeting three unexcavated sites (Deh-e Now, Tepe Senjar and Liyan) in Iran, this project aims to investigate Elam at its height during the 2nd millennium B.C. Archaeological excavations will be undertaken over a 5 year period and materials which have rarely received attention ....Elam in the 2nd millennium B.C.: A multi-regional approach. Although it was one of the Near East's most powerful ancient states, Elam has received less scholarly attention than its neighbours. Using an innovative approach targeting three unexcavated sites (Deh-e Now, Tepe Senjar and Liyan) in Iran, this project aims to investigate Elam at its height during the 2nd millennium B.C. Archaeological excavations will be undertaken over a 5 year period and materials which have rarely received attention in the past will be analysed using a wide range of scientific techniques. The project will be the first major investigation of Elam in almost 25 years.Read moreRead less
Methods to infer dense genomic information from sparsely genotyped populations. Prediction of phenotype based on DNA polymorphisms or sequence has important applications such as prediction of disease risk in human medicine and prediction of genetic value in plant or animal breeding. This project will enhance precision and lower the cost of association studies leading to substantial increase in accuracy of such predictions. This will allow more effective genetic improvement, particularly of diff ....Methods to infer dense genomic information from sparsely genotyped populations. Prediction of phenotype based on DNA polymorphisms or sequence has important applications such as prediction of disease risk in human medicine and prediction of genetic value in plant or animal breeding. This project will enhance precision and lower the cost of association studies leading to substantial increase in accuracy of such predictions. This will allow more effective genetic improvement, particularly of difficult but important traits such as disease resistance, reduced green-house gas emissions and product quality. The same methods can be extended to improve genetic improvement in plants and better prediction of human disease risk. Read moreRead less