Novel Statistical Methods For Genetic Epidemiology
Funder
National Health and Medical Research Council
Funding Amount
$481,505.00
Summary
We are in the midst of a genomics revolution that is transforming epidemiology, medicine and drug discovery. However, the scarcity of sophisticated statistical techniques to deal with the complicated problems inherent in genetic investigations of complex diseases is currently the critical factor limiting the success of human gene discovery programs. Statistical genetic methodology is currently one of the fastest developing areas of epidemiology. In information-intensive' areas such as genetic ep ....We are in the midst of a genomics revolution that is transforming epidemiology, medicine and drug discovery. However, the scarcity of sophisticated statistical techniques to deal with the complicated problems inherent in genetic investigations of complex diseases is currently the critical factor limiting the success of human gene discovery programs. Statistical genetic methodology is currently one of the fastest developing areas of epidemiology. In information-intensive' areas such as genetic epidemiology, genomics, and proteomics, there is a high demand for data analysis and statistical skills. WA has some world class expertise in statistical science, both in academia and in industry. However, this expertise has not yet been applied in a system way to genetic data analysis. We propose to undertake advanced methodological research in statistical genetics and bioinformatics, to produce easy-to-use and accessible software tools and resources that allow methodological advances to be accessed by the Australian research community, and to apply our new methods and tools both to specific disease research and to the developing human genome epidemiology (HuGE) enterprise in WA. These new initiatives in methodological research will draw together a number of currently separate research strands and will provide new tools and resources that will allow applied Australian programs to improve the efficiency of their research into the causes of important. Methodological development in both bioinformatics and statistical genetics are recognized international areas of need.Read moreRead less
"I think; therefore I am": Loneliness and neurodevelopmental disorders. This project aims to develop a 3-D animated program for adolescents with neurodevelopmental disorders (NDDs) that alters the automatic biases arising from their everyday social communication difficulties (including via social media), which result in negative thought patterns and loneliness. Negative thought patterns, which are arguably the hallmarks of, and causal in, the development of emotional dysfunction are amplified by ...."I think; therefore I am": Loneliness and neurodevelopmental disorders. This project aims to develop a 3-D animated program for adolescents with neurodevelopmental disorders (NDDs) that alters the automatic biases arising from their everyday social communication difficulties (including via social media), which result in negative thought patterns and loneliness. Negative thought patterns, which are arguably the hallmarks of, and causal in, the development of emotional dysfunction are amplified by loneliness, and adolescents with NDDs experience significantly greater levels of loneliness. Altering these negative thought patterns via an engaging 3-D animated program offers great potential to improve educational and social-emotional outcomes along with generating economic benefits nationally and internationally.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100789
Funder
Australian Research Council
Funding Amount
$401,808.00
Summary
Social media influencers as conduits of knowledge in Australia and Asia. This project aims to evaluate how social media influencers can become conduits to communicate information among young people between Australia and East Asia. As icons on the internet who are experts in holding attention and amplifying content, influencers have expanded from being mere commercial enterprises to being conduits of public service information by reaching wide, diverse, and sometimes marginalised youth audiences ....Social media influencers as conduits of knowledge in Australia and Asia. This project aims to evaluate how social media influencers can become conduits to communicate information among young people between Australia and East Asia. As icons on the internet who are experts in holding attention and amplifying content, influencers have expanded from being mere commercial enterprises to being conduits of public service information by reaching wide, diverse, and sometimes marginalised youth audiences with important socio-cultural messages. This project will glean lessons from leading influencer ecologies in East Asia (Seoul, Shanghai and Tokyo), to understand how we can use internet-native communication formats to improve inter-cultural knowledge and relations in Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100148
Funder
Australian Research Council
Funding Amount
$460,000.00
Summary
TrISMA - Tracking Infrastructure for Social Media Analysis. Tracking infrastructure for social media analysis: The tracking infrastructure for social media analysis (TrISMA) project establishes state-of-the-art technical and organisational infrastructure for the tracking of public communication by Australian users of social media, at large scale, in real time, and for the long term, addressing a significant gap in national research infrastructure. Social media are increasingly embedded in the Au ....TrISMA - Tracking Infrastructure for Social Media Analysis. Tracking infrastructure for social media analysis: The tracking infrastructure for social media analysis (TrISMA) project establishes state-of-the-art technical and organisational infrastructure for the tracking of public communication by Australian users of social media, at large scale, in real time, and for the long term, addressing a significant gap in national research infrastructure. Social media are increasingly embedded in the Australian media ecology, and systematic analyses of how public communication takes place via social media provide rich insights into a range of issues and debates of high importance to our society.Read moreRead less
A hand up: Disrupting the communication of intergenerational welfare dependency. Some families rely permanently on welfare support and communicate this dependency to the next generation. Children growing up in these families find it difficult to break out of poverty. With the help of twelve families and members of the St Vincent de Paul Society (Western Australia), this project aims to create ethnographies which illuminate turning points and opportunities for change. It will look to use creative ....A hand up: Disrupting the communication of intergenerational welfare dependency. Some families rely permanently on welfare support and communicate this dependency to the next generation. Children growing up in these families find it difficult to break out of poverty. With the help of twelve families and members of the St Vincent de Paul Society (Western Australia), this project aims to create ethnographies which illuminate turning points and opportunities for change. It will look to use creative and educational interventions to explore new ways of delivering services and disrupting the communication of welfare dependency. Ending inherited poverty is a significant step in helping individuals reach their potential and frees resources for people facing sudden hardship.Read moreRead less
Neurodevelopmental disorders and loneliness: School predictors & outcomes. This project aims to establish trajectories of loneliness across the 10-18 year developmental period in adolescents with neuro-developmental disorders (NDDs). This is significant because adolescence is the peak period for loneliness and the social communication difficulties experienced by adolescents with NDDs place them at greater risk of loneliness. Lower levels of school attendance, connectedness and mental well-being, ....Neurodevelopmental disorders and loneliness: School predictors & outcomes. This project aims to establish trajectories of loneliness across the 10-18 year developmental period in adolescents with neuro-developmental disorders (NDDs). This is significant because adolescence is the peak period for loneliness and the social communication difficulties experienced by adolescents with NDDs place them at greater risk of loneliness. Lower levels of school attendance, connectedness and mental well-being, and higher rates of disruptive behaviour, expulsion, drop-out, depression, social withdrawal, and suicide ideation are strongly linked to loneliness. Therefore predicting critical times in trajectories will enhance emotional, behavioural and school related outcomes and optimise economic, societal and quality of life benefits.Read moreRead less
An ethnographic investigation into the everyday work and communication cultures of public transport transit guards: reducing risk and injury. This research improves the safety of public transport for workers and passengers with flow-on benefits at local and national levels. The main health and safety risk transit guards face is attacks upon them, or injury incurred while intervening in assaults they witness. Conventional initiatives have not impacted greatly on injury rates but culture and commu ....An ethnographic investigation into the everyday work and communication cultures of public transport transit guards: reducing risk and injury. This research improves the safety of public transport for workers and passengers with flow-on benefits at local and national levels. The main health and safety risk transit guards face is attacks upon them, or injury incurred while intervening in assaults they witness. Conventional initiatives have not impacted greatly on injury rates but culture and communication change strategies offer potential ways forward. Strategies that reduce incidents confer clear community benefits and competitive advantage. Effective management of such challenges assists with the recruitment and retention of appropriate staff, improving profitability. Benefits include reduced costs of public transport, increased passenger load, and positive environmental impacts.Read moreRead less
Toddlers and tablets: exploring the risks and benefits 0-5s face online. Children aged between zero and five are experiencing an extraordinary shift in media consumption. They intuitively swipe screens and press buttons on tablet computers and smartphones, using apps and accessing the internet. With an estimated five-fold increase in their tablet usage (2012 to 2013), there is an urgent need for research and policy development to maximise benefit and minimise risk. This project is intended to in ....Toddlers and tablets: exploring the risks and benefits 0-5s face online. Children aged between zero and five are experiencing an extraordinary shift in media consumption. They intuitively swipe screens and press buttons on tablet computers and smartphones, using apps and accessing the internet. With an estimated five-fold increase in their tablet usage (2012 to 2013), there is an urgent need for research and policy development to maximise benefit and minimise risk. This project is intended to investigate family practices and attitudes around very young children's internet use in Australia and the United Kingdom, and is expected to contribute to public debate and evidence-based policy in Australia, the United Kingdom and Ireland. It aims to develop recommendations for policy makers and offers guidelines for parents of three age groups: zero to one, two to three and four to five.Read moreRead less
TSuNAMi: Time Series Network Animal Modelling. Our proposal is motivated by and based upon the successful representation of time series as a network (or graph). We construct an abstract representation of a system from measurements of its changing behaviour over time. Properties of that structure (the network) then allow us to infer diagnostic information of the system. Specifically, we propose to apply this to livestock welfare during transport. By measuring the biological and environment condi ....TSuNAMi: Time Series Network Animal Modelling. Our proposal is motivated by and based upon the successful representation of time series as a network (or graph). We construct an abstract representation of a system from measurements of its changing behaviour over time. Properties of that structure (the network) then allow us to infer diagnostic information of the system. Specifically, we propose to apply this to livestock welfare during transport. By measuring the biological and environment condition of the animal we construct a network representation of that system. Geometric features of that network can then be used to infer health or duress of the subject. This proposal will develop the generic mathematical machinery to connect geometric features of the network with system behaviour. Read moreRead less
A Structural Investigation Into The T-cell Response To Epstein Barr Virus Infection
Funder
National Health and Medical Research Council
Funding Amount
$549,000.00
Summary
X-ray crystallography is an essential tool for solving the three-dimensional structure of proteins. Proteins control the biological processes within the cell and it is the precise shape of proteins that determines how they function. Depending on the particular sequence of the amino acids, the so-called building unit of the proteins, the protein molecule bends and forms a distinct, complex shape. This specific three-dimensional shape allows the protein to undertake its specific function, such as ....X-ray crystallography is an essential tool for solving the three-dimensional structure of proteins. Proteins control the biological processes within the cell and it is the precise shape of proteins that determines how they function. Depending on the particular sequence of the amino acids, the so-called building unit of the proteins, the protein molecule bends and forms a distinct, complex shape. This specific three-dimensional shape allows the protein to undertake its specific function, such as binding to other proteins, acting as an enzyme or interacting with nucleic acids. To determine how a protein acts, it is vital to know the precise three-dimensional shape at the atomic level. This proposal is concerned with understanding the precise shape of proteins that control the immune response to Epstein Barr Virus. Epstein Barr Virus is an ubiquitous human pathogen that has being linked to a number of cancers. This work will further our understanding of the immune response to Epstein Barr Virus.Read moreRead less