Neuroimaging changes underpinning improvements in cognition in the elderly. Natural supplements are often used to improve brain and cognitive function, however, we do not know how these supplements work in the brain. Using novel brain imaging scans, the project will investigate whether 12-month administration of two promising natural supplements improves brain markers of ageing and cognitive decline in an elderly population.
Examining healthcare professionals' communication across the surgical pathway to improve patient safety. Recent data show breakdowns in communication contributed to 16% of sentinel events in Australia, the majority of which were of a surgical nature. Financial costs associated with adverse events are enormous, estimated at around $A2billion/year. Economic burden is predicted to increase with further complexities surrounding patients' surgical care. This study will result in new knowledge about c ....Examining healthcare professionals' communication across the surgical pathway to improve patient safety. Recent data show breakdowns in communication contributed to 16% of sentinel events in Australia, the majority of which were of a surgical nature. Financial costs associated with adverse events are enormous, estimated at around $A2billion/year. Economic burden is predicted to increase with further complexities surrounding patients' surgical care. This study will result in new knowledge about communication patterns to inform the development of reporting methods and strategies that positively influence the practices of healthcare professionals. Strategies could be extrapolated to the broader healthcare sector, and provide tactical direction aimed at averting clinical errors, preventing patient harm and reducing healthcare costs.Read moreRead less
Cellular genomic approach to the pathogenesis of multiple sclerosis. This project compares the levels of gene usage in two important immune cell types between patients with multiple sclerosis and people who do not have the disease. It aims to identify the molecular basis for the disease, in order to identify new diagnostic, preventative and treatment options.
Biophysical identification of natural human antibody targets. A natural human antibody, PAT-SM6, isolated using technology developed by the partner organisation (Patrys), offers promise as a therapy to reduce mortalities due to cancer, the leading cause of death in Australia. The novelty of the approach pioneered by Patrys is the direct production of human antibodies which avoids undesirable side effects associated with the use of antibodies containing non-human components. This project is to ....Biophysical identification of natural human antibody targets. A natural human antibody, PAT-SM6, isolated using technology developed by the partner organisation (Patrys), offers promise as a therapy to reduce mortalities due to cancer, the leading cause of death in Australia. The novelty of the approach pioneered by Patrys is the direct production of human antibodies which avoids undesirable side effects associated with the use of antibodies containing non-human components. This project is to discover the specificity of PAT-SM6 for proteins and protein complexes and how these interactions lead to tumour cell death. This work will enhance the effectiveness of human antibody therapies and help in the development of this fast growing area within the biotechnology industry in Australia.Read moreRead less
Bilateral Cochlear Implants for Children: Does a Second Implant Improve Language, Psychosocial and Other Outcomes? Severe-profound congenital hearing loss engenders significant costs to society. In 2005, specialised education cost -- on average $25,000 per child, loss of productivity cost -- $6.7 billion, and social security benefits were paid to approximately 129,000 individuals who were unemployed due to hearing loss. If bilateral cochlear implantation results in improved language, social dev ....Bilateral Cochlear Implants for Children: Does a Second Implant Improve Language, Psychosocial and Other Outcomes? Severe-profound congenital hearing loss engenders significant costs to society. In 2005, specialised education cost -- on average $25,000 per child, loss of productivity cost -- $6.7 billion, and social security benefits were paid to approximately 129,000 individuals who were unemployed due to hearing loss. If bilateral cochlear implantation results in improved language, social development, and academic outcomes, the community benefits arising will be greatly improved quality of life for these individuals and significant savings to society. In partnership with Cochlear Ltd, this study will provide some of the first data worldwide comparing the effects of an additional implant on language, social and educational outcomes.Read moreRead less
Development of the PD GeneChip: a research and diagnostic tool for Parkinson's disease. The PD GeneChip will provide both social and economic benefits to Australia. It will be a key research platform for Australian scientists, and will facilitate collaboration both within Australia and overseas. It will assist with health care management of PD (Parkinson's disease) patients by providing a cost-effective diagnostic tool and the possibility of predicting the clinical course of disease. This inform ....Development of the PD GeneChip: a research and diagnostic tool for Parkinson's disease. The PD GeneChip will provide both social and economic benefits to Australia. It will be a key research platform for Australian scientists, and will facilitate collaboration both within Australia and overseas. It will assist with health care management of PD (Parkinson's disease) patients by providing a cost-effective diagnostic tool and the possibility of predicting the clinical course of disease. This information will provide the basis for tailoring treatment to a patients needs. It is anticipated that marketing of the PD GeneChip within Australia and overseas may produce revenue of at least $40 million annually.Read moreRead less
Generating a targeted mutation resource in zebrafish. How do genes function to build organisms and how are they regulated to produce organs and tissues? Using a new technique to target specific genes in the genome of zebrafish, this project will determine how genes control formation of different tissues. The new gene "knockout" technology will fundamentally change our understanding of how genes work during development.
Improving Employment Outcomes in Early Psychosis: Social and Economic Benefits of Early Intervention. Over 74% of people with psychotic illnesses like schizophrenia, despite wanting to work, are unemployed, more than any other disability group. This project examines an evidence-based method in which young people with psychosis can be effectively supported to return to the competitive labour market. In Australia, unemployment of people with schizophrenia costs $927 million, over half the total il ....Improving Employment Outcomes in Early Psychosis: Social and Economic Benefits of Early Intervention. Over 74% of people with psychotic illnesses like schizophrenia, despite wanting to work, are unemployed, more than any other disability group. This project examines an evidence-based method in which young people with psychosis can be effectively supported to return to the competitive labour market. In Australia, unemployment of people with schizophrenia costs $927 million, over half the total illness costs of schizophrenia. For people with psychosis, unemployment exacerbates social and economic marginalisation. This project aims to reduce the economic cost of unemployment among the mentally ill as well as using employment to reduce social marginalisation of people with mental illness.Read moreRead less
Developing technologies that support the genetic modification of rats. Rats and the mouse play critical roles in medical research. Until recently, the targeted genetic modification of a mammal was limited to the mouse. This was due to a technology that was unique to the mouse: embryonic stem (ES) cells. These cells have not been isolated from any other species. The recent development of animal cloning allows for an alternate strategy for targeting genes. We propose to develop cloning strate ....Developing technologies that support the genetic modification of rats. Rats and the mouse play critical roles in medical research. Until recently, the targeted genetic modification of a mammal was limited to the mouse. This was due to a technology that was unique to the mouse: embryonic stem (ES) cells. These cells have not been isolated from any other species. The recent development of animal cloning allows for an alternate strategy for targeting genes. We propose to develop cloning strategies in the rat that supports the genetic modification of this animal. The development of this technology will bring considerable benefits to the areas of physiological research and drug design.Read moreRead less
Influence of an innovative shoe design on lower limb joint loading during walking. This project will provide new knowledge about the effects of shoe design features on lower limb loading and the influence of obesity and knee condition on the shoe-mediated biomechanical effects. This will be of relevance to researchers and clinicians. It is also likely to contribute to a marketable commercial product, a shoe designed to reduce knee loading. This shoe has the potential to contribute to reducing th ....Influence of an innovative shoe design on lower limb joint loading during walking. This project will provide new knowledge about the effects of shoe design features on lower limb loading and the influence of obesity and knee condition on the shoe-mediated biomechanical effects. This will be of relevance to researchers and clinicians. It is also likely to contribute to a marketable commercial product, a shoe designed to reduce knee loading. This shoe has the potential to contribute to reducing the societal and personal burden of knee osteoarthritis, one of the most prevalent and costly chronic conditions in the developed world. Read moreRead less