Neuroimaging changes underpinning improvements in cognition in the elderly. Natural supplements are often used to improve brain and cognitive function, however, we do not know how these supplements work in the brain. Using novel brain imaging scans, the project will investigate whether 12-month administration of two promising natural supplements improves brain markers of ageing and cognitive decline in an elderly population.
Studying the impact of pulsed magnetic fields on neural tissue. This project will determine the optimal parameters of pulsed magnetic fields for treating the ageing and/or damaged brain. The safety features, low cost and compact size of the medical device being investigated maximise compliance and make it relevant to populations in remote and rural areas.
A Randomised Controlled Trial Of Interventional Versus Conservative Treatment Of Primary Spontaneous Pneumothorax
Funder
National Health and Medical Research Council
Funding Amount
$412,315.00
Summary
Primary spontaneous pneumothorax (PSP) is a collapsed lung that occurs in otherwise healthy people without underlying lung disease. Current standard treatment is to insert a chest drain into the chest to remove the air around the collapsed lung so that the lung re-inflates rapidly ("interventional treatment"). We will determine whether doing nothing, i.e. letting the lung re-inflate slowly on its own over several weeks ("conservative treatment"), is just as good or even better for patients.
Evaluation of a psychological anti-doping intervention for athletes. This project builds on previous research that developed a psychological profile of athletes susceptible to doping. The primary objective is to refine and pilot an intervention involving psycho-educational activities and exercises that can be used to reduce an athlete's susceptibility to doping. Current anti-doping programs focus on knowledge of banned substances, reporting and testing requirements, and penalties for noncomplian ....Evaluation of a psychological anti-doping intervention for athletes. This project builds on previous research that developed a psychological profile of athletes susceptible to doping. The primary objective is to refine and pilot an intervention involving psycho-educational activities and exercises that can be used to reduce an athlete's susceptibility to doping. Current anti-doping programs focus on knowledge of banned substances, reporting and testing requirements, and penalties for noncompliance. These programs ignore psychological variables that may render an athlete susceptible to doping. The successful application of the psychological anti-doping intervention is expected to provide an internationally significant contribution to doping prevention and the social science research on which it is based.Read moreRead less
Do perceptions of morality of alcohol, tobacco & cannabis use influence uptake in high school? In Australia, the cost of drug use was estimated at $34.4 billion in 1998-89. Preventing or delaying alcohol, tobacco and illicit drug use among adolescents is a way of reducing substance use among adults, and therefore, reduces the health, social and economic costs associated with substance use. This study will assess the protective/vulnerability effect of a range of variables on youth substance use i ....Do perceptions of morality of alcohol, tobacco & cannabis use influence uptake in high school? In Australia, the cost of drug use was estimated at $34.4 billion in 1998-89. Preventing or delaying alcohol, tobacco and illicit drug use among adolescents is a way of reducing substance use among adults, and therefore, reduces the health, social and economic costs associated with substance use. This study will assess the protective/vulnerability effect of a range of variables on youth substance use including morality and legitimacy concepts. These data will guide the development of curriculum components to enhance the effect of school-based interventions with respect to substance use, and provide practical recommendations for community interventions targeted at substance use.Read moreRead less
What works best for youth smoking prevention messages? In Australia, tobacco smoking is the leading cause of preventable death and disease, resulting in over 19,000 deaths annually. The morbidity and mortality associated with smoking costs the community over $21 billion a year. People who start smoking when they are young are more likely to smoke heavily as adults, to become more dependent on nicotine and to be at increased risk of smoking-related illness or death. This research study will provi ....What works best for youth smoking prevention messages? In Australia, tobacco smoking is the leading cause of preventable death and disease, resulting in over 19,000 deaths annually. The morbidity and mortality associated with smoking costs the community over $21 billion a year. People who start smoking when they are young are more likely to smoke heavily as adults, to become more dependent on nicotine and to be at increased risk of smoking-related illness or death. This research study will provide practical recommendations for future tobacco control television advertising targeted at youth in terms of the elements featured in tobacco control advertisements that increase advertising effectiveness. Read moreRead less
Identification of Australian-bred apple and plum varieties with enhanced health attributes. Improved prevention could save Australia $4 billion annually in health care costs, mainly in the area of cardiovascular disease. A higher flavonoid intake has been estimated to reduce the risk of cardiovascular disease by about 20%. Apples are important sources of flavonoids in the diet. The proposed project involves collaboration between the Department of Agriculture and Food Western Australia and the U ....Identification of Australian-bred apple and plum varieties with enhanced health attributes. Improved prevention could save Australia $4 billion annually in health care costs, mainly in the area of cardiovascular disease. A higher flavonoid intake has been estimated to reduce the risk of cardiovascular disease by about 20%. Apples are important sources of flavonoids in the diet. The proposed project involves collaboration between the Department of Agriculture and Food Western Australia and the University of Western Australia. The aim is to identify progeny of both the apple and plum breeding programs that have elite levels of flavonoids and to demonstrate health benefits of a high-flavonoid apple. This could lead to significant benefits to Australian horticulture and to population health.Read moreRead less
Exploitation of a Novel Drug Target for Controlling Animal Trypanosomiasis. Trypanosomiasis greatly reduces livestock productivity in countries where it is endemic and is a threat to livestock and native wildlife in countries such as Australia where it is exotic but there is a risk of entry. New trypanocidal drugs with different modes of action are urgently needed to overcome growing resistance. This project aims to characterise trypanosome tubulin and, with this information, produce new tubulin ....Exploitation of a Novel Drug Target for Controlling Animal Trypanosomiasis. Trypanosomiasis greatly reduces livestock productivity in countries where it is endemic and is a threat to livestock and native wildlife in countries such as Australia where it is exotic but there is a risk of entry. New trypanocidal drugs with different modes of action are urgently needed to overcome growing resistance. This project aims to characterise trypanosome tubulin and, with this information, produce new tubulin-binding compounds for assessment in vitro and in vivo. Upon completion of the project it is expected that drug binding sites on trypanosome tubulin will be characterised and at least one candidate for clinical trials identified.Read moreRead less
A mental health "thermometer" to monitor and prevent adverse treatment outcomes and self-harm among psychiatric inpatients. Our project stands to prevent adverse outcomes in psychiatric patients. An estimated 660 000 people are admitted to psychiatric hospitals each year; 99 000 of these people are worse off following treatment (assuming a deterioration rate of 15 per cent). Since monitoring can halve that rate, if this project can halve the deterioration rate again, then 24 750 inpatients acr ....A mental health "thermometer" to monitor and prevent adverse treatment outcomes and self-harm among psychiatric inpatients. Our project stands to prevent adverse outcomes in psychiatric patients. An estimated 660 000 people are admitted to psychiatric hospitals each year; 99 000 of these people are worse off following treatment (assuming a deterioration rate of 15 per cent). Since monitoring can halve that rate, if this project can halve the deterioration rate again, then 24 750 inpatients across the nation would not be worse off after treatment representing an annual saving of nearly $19.2 million per annum and reduce the number of patients who fall into a cycle of admission and readmission. Further, although suicide occurs in less than one per cent of admissions, if this research is able to predict and then reduce the suicide rate by as little as 10 per cent, then 660 lives can be saved each year.Read moreRead less
Driving Change: Using Emergency Department Data To Reduce Alcohol-related Harm
Funder
National Health and Medical Research Council
Funding Amount
$1,468,026.00
Summary
The proposed project is a system change within partner emergency departments, providing them the information and tools to act on both risky alcohol consumption in individual patients and the sources of alcohol in the community which cause the harm they experience. Most importantly, the proposed public health interventions act as a tool for emergency departments to regularly raise awareness with the public and policymakers regarding the impact of alcohol on patients, clinicians and hospitals.