Antipsychotic Medication In First-episode Psychosis: An RCT To Assess The Risk-benefit Ratio
Funder
National Health and Medical Research Council
Funding Amount
$1,141,117.00
Summary
There has been an increasing emphasis on intervening early in psychotic disorders. A fundamental principle in early intervention is “to do no harm” and benefits must outweigh the risks of treatment. While antipsychotic medication is very effective and evidence-based form of treatment for positive symptoms in most first episode psychosis (FEP) patients it has risks. This study has the potential to determine whether antipsychotic medication should be the initial treatment option for FEP.
The N-ICE Trial: A Randomised Controlled Trial Of The Safety And Efficacy Of N-Acetyl Cysteine (NAC) As A Pharmacotherapy For Methamphetamine (“ice”) Dependence
Funder
National Health and Medical Research Council
Funding Amount
$1,551,368.00
Summary
Crystalline methamphetamine (aka ‘ice’) is a significant public health concern in Australia and globally. Currently there are no approved medications to treat methamphetamine dependence. We will trial tN-acetyl-cysteine (NAC) as a medications for methamphetamine dependence.
Preventing mental health problems in children: a population-based cluster controlled trial. The National Mental Health Survey (2000) found 1 in 7 children have externalising (aggression) and internalising (anxiety, depression) problems. Early mental health problems beget later problems with high costs to society, including clinical, remedial education and criminal justice services. Hence, early prevention is vital for national well-being and productivity. The few preventive early childhood progr ....Preventing mental health problems in children: a population-based cluster controlled trial. The National Mental Health Survey (2000) found 1 in 7 children have externalising (aggression) and internalising (anxiety, depression) problems. Early mental health problems beget later problems with high costs to society, including clinical, remedial education and criminal justice services. Hence, early prevention is vital for national well-being and productivity. The few preventive early childhood programs to date are limited in effectiveness and not truly population-based. The proposed parenting / family support trial aims to overcome these obstacles, by comparing and costing two approaches that can be implemented within whole communities. The trial will help clarify optimal primary care to prevent mental health problems early in life.Read moreRead less
Improving Outcomes For Children With ADHD: Mapping Developmental Trajectories And Developing Targeted Interventions
Funder
National Health and Medical Research Council
Funding Amount
$419,180.00
Summary
Attention deficit hyperactivity disorder (ADHD) is one of the most common mental health disorders affecting young people in Australia. My research program aims to generate new knowledge to inform clinical practice for children with ADHD including: 1) long-term outcomes and key predictors of outcomes; and 2) novel treatments to improve the lives of children and families. Growth of my research program is feasible and underpinned by existing platforms including numerous NHMRC-funded studies.
Impact Of A Sleep Intervention In Children With ADHD: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$384,230.00
Summary
Attention deficit hyperactivity disorder (ADHD) affects up to 7.5% of Australian children. Between 50 and 70% of parents also report sleep problems (eg night waking, insomnia) in their child with ADHD. Such sleep problems are associated with poorer child behaviour, concentration, and school attendance as well as poorer parent mental health and work attendance. This randomised controlled trial will determine whether treating sleep problems in children with ADHD can improve these outcomes.
Preventing Early Internalising Problems In The Preschool Setting: Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$893,870.00
Summary
Internalising mental health problems reflect inner emotional distress and encompass all symptoms of anxiety and depression. Affecting 1 in 7 Australian school-age children, many internalising problems persist into adulthood, impacting on personal wellbeing, family relations and workforce capabilities. This randomised prevention trial in the preschool-setting, screens for children at-risk and tests if a parenting program can reduce internalising problems across the population by school-entry.
Diagnosis of depressive disorder and risk for depression in adolescents using acoustic speech analysis. Depression is the most common mental health problem in young people in Australia. Early diagnosis can minimise the disturbance of typical functioning and development of social and academic skills. Current assessment techniques consume significant time in urgent clinical situations, where an immediate assessment of risk is required. An automatic diagnostic system will provide an important objec ....Diagnosis of depressive disorder and risk for depression in adolescents using acoustic speech analysis. Depression is the most common mental health problem in young people in Australia. Early diagnosis can minimise the disturbance of typical functioning and development of social and academic skills. Current assessment techniques consume significant time in urgent clinical situations, where an immediate assessment of risk is required. An automatic diagnostic system will provide an important objective indicator giving an immediate quantitative assessment of the mental state of a patient. The quantitative measure given by the diagnostic system proposed will give physicians and therapists an improved metric by which they can gauge the effectiveness of various treatments in reducing depression and suicidality. Read moreRead less
Welfare receipt, demoralisation and mental health: how can welfare reform promote personal wellbeing and social inclusion? Welfare recipients are more likely to experience mental disorders and have poor wellbeing than non-recipients, and this can be a barrier to employment. This project examines the factors that may improve their mental health, promote employment outcomes, and help the Commonwealth Government develop effective welfare reform policies.
Maternal mental health and anaemia as determinants of infant health and development in resource constrained settings. A healthy start to life is an explicit Australian priority. Maternal health is a major determinant of the health and development of infants. This international collaborative project will contribute evidence about two maternal health conditions: mental disorders and anaemia, and their effects on infant health and development, through research in Vietnam where both are prevalent. ....Maternal mental health and anaemia as determinants of infant health and development in resource constrained settings. A healthy start to life is an explicit Australian priority. Maternal health is a major determinant of the health and development of infants. This international collaborative project will contribute evidence about two maternal health conditions: mental disorders and anaemia, and their effects on infant health and development, through research in Vietnam where both are prevalent. The findings will inform interventions to improve the health of mothers and infants in all resource-constrained settings, including among indigenous and refugee groups in Australia. It will advance Australia's international relations by strengthening a partnership with Viet Nam and contributing to a World Health Organization priority area. Read moreRead less
Identifying Models of Personal and Community Resilience that enhance Psychological Wellness: A Stanthorpe Study. There are significant mental health problems in rural and remote Australia. Researchers in Australia are only just beginning to investigate mental health, and prevention is identified as a primary focus. A new innovative approach to mental health prevention is identifying and using characteristics that will enhance individual and community psychological wellness. Resilience has been i ....Identifying Models of Personal and Community Resilience that enhance Psychological Wellness: A Stanthorpe Study. There are significant mental health problems in rural and remote Australia. Researchers in Australia are only just beginning to investigate mental health, and prevention is identified as a primary focus. A new innovative approach to mental health prevention is identifying and using characteristics that will enhance individual and community psychological wellness. Resilience has been identified as one of those characteristics. The aim of this project is to work collaboratively with key stakeholders from a rural community (Stanthorpe in South East Queensland) to develop, implement, and evaluate a model that enhances psychological wellness in rural people and communities.Read moreRead less