Improving The Impact Of Perioperative Clinical Trials
Funder
National Health and Medical Research Council
Funding Amount
$494,733.00
Summary
This research focuses on (i) Designing and conducting large multicentre trials in anaesthesia and surgery, (ii) Confirming new patient-centred outcome measures in surgery, such as patient-rated quality of recovery, returning home after surgery, and disability-free survival; and (iii) Innovative trial designs to improve the efficiency (less burden, lower costs) of trials.
Improving Children's Respiratory Health Through Better Evidence And Knowledge
Funder
National Health and Medical Research Council
Funding Amount
$568,892.00
Summary
Prevention and/or early treatment potentially change the child’s life trajectory for lung health as adults. This is particularly important in Aboriginal and Torres Strait Islander children, as respiratory illness is very common with long term consequences. In my fellowship, I will undertake appropriate clinical studies (treatment and preventative) that are most likely to improve lung health outcomes, particularly in conditions relevant in Indigenous children.
Optimising Emergency And Trauma Systems Through Evidence Based Pathways
Funder
National Health and Medical Research Council
Funding Amount
$418,049.00
Summary
Developing systems for emergency and trauma care based on strong evidence and robust data systems is crucial to the acute health sector. Through an extensive, well recognised collaboration of research groups at The Alfred, Monash and the National Trauma Research Institute, we aim to undertake world leading systems development both locally and globally, focusing on prehospital, emergency and trauma clinical care pathways significantly reducing mortality and improving functional outcomes.
This fellowship will allow the applicant to continue his studies into understanding and intervening in osteoarthritis. He will use a combination of observational studies and clinical trials to achieve this purpose.
This fellowship will allow the applicant to continue to study the major musculoskeletal diseases in Australia (osteoarthritis, osteoporosis and rheumatoid arthritis) using a combination of observational and interventional studies.
Early Life Approaches To Obesity Prevention – The Role Of The In-utero Environment
Funder
National Health and Medical Research Council
Funding Amount
$575,662.00
Summary
This proposal will comprehensively evaluate the role of maternal overweight and obesity, gestational weight gain, and the effects of antenatal dietary and lifestyle interventions on maternal, infant and childhood health outcomes. Over 50% of pregnant women are overweight or obese, with adverse outcomes for maternal and infant health, both immediately related to pregnancy, and in the longer term. Outcomes from this proposal will inform clinical guidelines and improve practice.
The growing momentum towards elimination of malaria and the need to control of drug-resistant parasites means that new drugs and vaccines are needed. In this Fellowship I will use the human malaria challenge system that I have developed to test whether new drugs and vaccines for malaria are working sufficiently well to justify their full development. In this system healthy volunteers are deliberately infected with malaria and then cured before they become unwell.
Implementation Of Highly Effective Therapy For Hepatitis C
Funder
National Health and Medical Research Council
Funding Amount
$569,219.00
Summary
Hepatitis C is a major public health issue in Australia, and globally, with escalating liver disease burden. Highly effective interferon-free HCV regimens will be available from 2016 and have the potential to provide one of the greatest advances in clinical medicine in recent decades. Development of implementation strategies for new HCV therapies, particularly for highly marginalised populations including people who inject drugs and prisoners, is crucial to provide broad public health impact.
Discovery To Therapy Implementation In Acute Stroke
Funder
National Health and Medical Research Council
Funding Amount
$585,269.00
Summary
Advances in acute stroke therapies are occurring rapidly but challenges remain in their safe and effective delivery to stroke sufferers. This research focuses on testing a potentially superior ‘clot busting’ drug therapy for acute stroke and on identifying reasons why one of the most widely used current therapies carries a risk of significant harm due to bleeding into the brain. The work also investigates how to better implement the newest form of acute therapy, mechanical blood clot extraction.
I am a practising hospital neurologist and world leader in the prevention and treatment of stroke. Our research aims to realise exciting new break-throughs for stroke sufferers by testing the effectiveness and safety of new treatments that promise to improve recovery of function of damaged brain and reduce disability after stroke, and to prevent recurrent strokes.