Reprogramming Macrophage Function In The Elderly To Rescue Impaired Inflammatory Responses To Muscle Injury
Funder
National Health and Medical Research Council
Funding Amount
$410,983.00
Summary
Muscle injury in the elderly often takes longer to heal than in younger people, however the cells responsible for this delayed healing are not well understood. Key inflammatory cells required for muscle repair in young hosts are macrophages. However, during aging we have shown that macrophage function is altered, but the mechanism is unknown. This project aims to determine the mechanisms behind age-related changes to macrophages and whether they can be targeted to improve elderly muscle repair.
Predicting Health And Disease In Australian Men Over The Age Of 80 Years - The Health In Men Study
Funder
National Health and Medical Research Council
Funding Amount
$528,754.00
Summary
Australia is ageing rapidly but we still do not know whether the risk factors, such as health and lifestyle, that predict ill health in middle aged people, apply to people as they reach old age. This study of a large group of older men will examine the type and level of risk factors that apply to men aged beyond 75 years. It will not only determine rates of disability and mortality but also health service outcomes, including hospitalisation, and residential and community care usage.
How critical is the inflammatory response in senile plaque formation in a mutant APP transgenic mouse model? The aims of this project is to examine the brains of mice genetically engineered to produce a human mutant form of insoluble beta amyloid protein known to play a critical role in the development of Alzheimer's disease (AD). If the "trigger" for AD is an inflammatory reaction, then the relevant examination of the early stages of senile plaque formation in these animals could lead to pharma ....How critical is the inflammatory response in senile plaque formation in a mutant APP transgenic mouse model? The aims of this project is to examine the brains of mice genetically engineered to produce a human mutant form of insoluble beta amyloid protein known to play a critical role in the development of Alzheimer's disease (AD). If the "trigger" for AD is an inflammatory reaction, then the relevant examination of the early stages of senile plaque formation in these animals could lead to pharmaceutical intervention to delay the development of this debilitating disease. A 5 year delay would significantly reduce the number of people with AD, not only adding years of improved quality of life, but also saving hundreds of millions of Australian dollars in health costs.Read moreRead less
The Kids in Communities Study: national investigation of community level effects on children's developmental outcomes. This project (a cross-disciplinary collaboration) will investigate community level factors influencing early childhood developmental outcomes using a mixed methods approach in up to 10 communities across Australia. This will result in a potential set of measures or indicators that reflect communities that are good for children.
Community spirit, social transformation, sustainable partnership: community capacity building for community transformations. This partnership is at the forefront of developments in the provision of community services. The project will contribute to a growing international field of research focused on developing integrated frameworks for measuring community wellbeing. The community capacity building approach will serve as a best practice model for other Australian municipalities. The indicators a ....Community spirit, social transformation, sustainable partnership: community capacity building for community transformations. This partnership is at the forefront of developments in the provision of community services. The project will contribute to a growing international field of research focused on developing integrated frameworks for measuring community wellbeing. The community capacity building approach will serve as a best practice model for other Australian municipalities. The indicators are a tool for engaging communities in making informal decisions and developing shared goals; a policy tool for evidence based planning; and a reporting tool to track and communicate progress towards agreed goals and outcomes. The outcomes will be efficient use of available funding for community services and lower cost of provision of social welfare.Read moreRead less
Functional-trait approach to restoration of species-rich shrublands. The project aims to deliver management tools that will help mining companies to meet restoration targets and to improve the field of trait-based predictive restoration ecology. Species-rich kwongan shrublands of south-west Australia are a biodiversity treasure. Despite their global and national conservation value, little is known about which plant traits are most important for community assembly and diversity maintenance. This ....Functional-trait approach to restoration of species-rich shrublands. The project aims to deliver management tools that will help mining companies to meet restoration targets and to improve the field of trait-based predictive restoration ecology. Species-rich kwongan shrublands of south-west Australia are a biodiversity treasure. Despite their global and national conservation value, little is known about which plant traits are most important for community assembly and diversity maintenance. This project plans to use plant functional traits related to nutrient and water acquisition to predict plant community assembly under different soil resource availabilities and thus assist in successful rehabilitation of this native vegetation after closure of sand-mining operations.Read moreRead less
Pathways to better practice: developing human resources in child protection services for Indigenous communities in Western Australia and Queensland. This study addresses the serious and escalating problem of providing child protection services to Indigenous children and their families in rural and remote areas. Service delivery to rural and remote environments in Australia is a high cost exercise and, to date, little research has been conducted to understanding the complex nature of professiona ....Pathways to better practice: developing human resources in child protection services for Indigenous communities in Western Australia and Queensland. This study addresses the serious and escalating problem of providing child protection services to Indigenous children and their families in rural and remote areas. Service delivery to rural and remote environments in Australia is a high cost exercise and, to date, little research has been conducted to understanding the complex nature of professional (non-medical) interventions in communities with high proportions of Indigenous families and children. The study, conducted across two states, will contribute to national benefit in 3 key areas: the health and wellbeing of Indigenous children; skills shortage in rural areas and intergenerational change in professional disciplines.Read moreRead less
Bolstering commitment to positive social change through group-based interaction. Building on an impressive series of preliminary results, this research uses small group interaction to bolster commitment to work towards long-term goals. The methods explored in the proposal have the potential to boost commitment in the public, private, and community sectors by identifying the key factors responsible for sustaining long-term change. The research is relevant for efforts to combat racism, and to incr ....Bolstering commitment to positive social change through group-based interaction. Building on an impressive series of preliminary results, this research uses small group interaction to bolster commitment to work towards long-term goals. The methods explored in the proposal have the potential to boost commitment in the public, private, and community sectors by identifying the key factors responsible for sustaining long-term change. The research is relevant for efforts to combat racism, and to increase community support for international development and environmental sustainability. Benefits are expected both in terms of the promotion of positive attitudes in society and in overcoming apathy within organisations.Read moreRead less
Psychosocial and economic impacts of rare diseases on Australian children, families and health professionals. Rare childhood diseases have enormous impacts on children and families; health services, and health professionals. This project will enable Australia to lead the international research effort by using a coordinated approach to study the impacts of rare diseases in order to improve psychosocial, health and economic outcomes for children and families.
The neglected dimension of community liveability: Impact on social connectedness and active ageing. Quality of life and well being are essential to maintaining a healthy and socially-engaged population. This project takes an innovative trans-disciplinary approach in addressing the national research priority of Promoting and Maintaining Good Health and the associated goal, Ageing well, ageing productively through research that identifies the attributes of communities that foster or inhibit social ....The neglected dimension of community liveability: Impact on social connectedness and active ageing. Quality of life and well being are essential to maintaining a healthy and socially-engaged population. This project takes an innovative trans-disciplinary approach in addressing the national research priority of Promoting and Maintaining Good Health and the associated goal, Ageing well, ageing productively through research that identifies the attributes of communities that foster or inhibit social engagement. The outcomes of the project will inform policy makers, planners and service deliver organisations about ways to identify, improve or maintain safe housing, transport and community environments for the benefit of all Australians.Read moreRead less