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Developing Evidence Based Strategies For Addressing Childhood Vaccination Rejection
Funder
National Health and Medical Research Council
Funding Amount
$743,927.00
Summary
Parental rejection of vaccines is a global concern that threatens to undermine disease control. A lack of evidence hampers the responses to this complex and persistent problem. We will interview parents who don’t vaccinate their children to learn what influences their decisions. We will then hold community juries and a public engagement process to refine strategies for responding to vaccination rejection that are acceptable to a well informed citizenry, practical and ethically justified.
Identifying Undiagnosed HIV Infection Among Australian Gay Men: Delivering HIV Testing Through A National, Community-based Study
Funder
National Health and Medical Research Council
Funding Amount
$781,432.00
Summary
Gay men remain the group primarily affected by HIV in Australia. People with undiagnosed HIV infection contribute disproportionately to HIV transmission in Australia. This study will deliver HIV testing to gay men in community settings, provide test results to consenting participants and estimate the prevalence of HIV and undiagnosed HIV infection. It will contribute significantly to reducing the number of undiagnosed HIV infections in Australia by providing strategic knowledge to guide HIV prev ....Gay men remain the group primarily affected by HIV in Australia. People with undiagnosed HIV infection contribute disproportionately to HIV transmission in Australia. This study will deliver HIV testing to gay men in community settings, provide test results to consenting participants and estimate the prevalence of HIV and undiagnosed HIV infection. It will contribute significantly to reducing the number of undiagnosed HIV infections in Australia by providing strategic knowledge to guide HIV prevention programs.Read moreRead less
WOmen's Action For Mums And Bubs (WOMB): A Pragmatic Trial Of Participatory Women's Groups To Improve Indigenous Maternal And Child Health
Funder
National Health and Medical Research Council
Funding Amount
$1,766,216.00
Summary
There is strong evidence elsewhere that involving community women in decision-making about strategies to improve the health of mothers and babies is a cheap and effective way of improving health. The WOMB study tests whether community women's groups improve the quality of maternal and child health care and outcomes in Aboriginal and Torres Strait Islander communities, the cost-effectiveness and how it works.
Robust Bioinformatics For Predicting Bacterial Pathogens From Microbiome Sequencing
Funder
National Health and Medical Research Council
Funding Amount
$644,151.00
Summary
We propose to develop new methods for the identification of microbial pathogens using High Throughput DNA Sequencing (HTS). Study of the microbiome - the genes encoded by the assemblage of microbial species present in an environment - using HTS technologies is revolutionising our understanding of human-microbe interactions. Our proposed work includes fundamental computational and theoretical advances and applying these techniques to solve critical problems in pathogen detection.
Tailored Activities To Reduce Challenging Behaviours In Persons With Dementia Living At Home: The TAP Trial
Funder
National Health and Medical Research Council
Summary
Dementia is the greatest single contributor to the burden of disability for older people. Challenging behaviours are common and associated with reduced quality of life for the person with dementia and the caregiver. The Tailored Activities Program, delivered by occupational therapists, is novel. It targets the capacity of the person with dementia and provides a systematic way to match both capacity and personal interest to activity. We will conduct a randomized trial to test its effectiveness.
The Relationship Between Maternal And Infant Dietary Intake Of Fermentable Fibre, Gut Microbiota, Short Chain Fatty Acids And Allergic Disease And Asthma: A Population-derived Birth Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$871,700.00
Summary
The proposed study will involve the Barwon Infant Study (BIS) cohort of 1074 infants to provide the first systematic investigation of the hypotheses that the epidemic of allergic disease and asthma in many parts of the world relates to the paucity of fermentable fibre in the modern diet, and that the protective effect of fermentable fibre is mediated by changes in the organisms that colonise the gut and the metabolites that they produce.
Faecal Microbiota Transplantation For Active Ulcerative Colitis - A Randomised Controlled Trial: Clinical, Microbial & Immune Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$700,126.00
Summary
This is a placebo controlled clinical trial to see whether giving healthy donor faeces to people with active ulcerative colitis can get them into remission. We will also examine how long the donor microbiome stays in the recipients stool, and examine the effects of faecal transplantation on the immune response in the lining of the colon in recipients.
How Do Antibiotics Affect The Gastrointestinal Microbiome In Children?
Funder
National Health and Medical Research Council
Funding Amount
$215,000.00
Summary
Antibiotics, while vital, have potentially long term negative effects on antimicrobial resistance and other aspects of health. Microorganisms living in the human intestine, collectively the gastrointestinal microbiome, are believed to play a key role. Antibiotics can change the microbiome, and this is potentially important in children due to the longevity of health effects. We aim to determine the effect of different antibiotics (broad versus narrow) on the microbiome over time in children.
Characterisation Of Porphyromonas Gingivalis And Treponema Denticola Interactions In The Development Of A Pathogenic Biofilm
Funder
National Health and Medical Research Council
Funding Amount
$566,200.00
Summary
Gum disease (periodontitis) is an inflammatory disease caused by bacterial pathogens that is the major cause of tooth loss in adults. It is also associated with systemic diseases such as cardiovascular disease. In this study we will determine the mechanisms by which two bacterial species work together to produce the pathogenic dental plaque that causes disease.
Clinical Implications Of Trans-kingdom Microbial Interactions In The Transplanted Lung
Funder
National Health and Medical Research Council
Funding Amount
$631,909.00
Summary
Lung transplantation is a critical requirement for people with severe lung diseases. The lung is constantly exposed to bugs and viruses, which reside in the airways, and can be both beneficial or detrimental for lung health. This interaction between the immune system and these bugs can influence the health and longevity of the lung transplant. We aim to discover how we could target these interactions to improve the long-term success of lung transplantation.