Intervention Trial To Reduce Alcohol Related Harms Among High Risk Young Indigenous Australians
Funder
National Health and Medical Research Council
Funding Amount
$392,553.00
Summary
Indigenous Australians experience disproportionately high rates of drug and alcohol harms and young people are particularly vulnerable: over 50% of 10-17 year old juvenile detainees are Indigenous, despite comprising only 2% of the population. There is no reliable evidence about which interventions might reduce these harms. This study quantifies the benefits/costs of combining cognitive-behaviour therapy with a community-reinforcement strategy to reduce substance-related harms among young Indige ....Indigenous Australians experience disproportionately high rates of drug and alcohol harms and young people are particularly vulnerable: over 50% of 10-17 year old juvenile detainees are Indigenous, despite comprising only 2% of the population. There is no reliable evidence about which interventions might reduce these harms. This study quantifies the benefits/costs of combining cognitive-behaviour therapy with a community-reinforcement strategy to reduce substance-related harms among young Indigenous Australians.Read moreRead less
The Gudaga Study is a unique study of Aboriginal children in an urban environment on the eastern seaboard of Australia. Children were recruited at birth and have been followed up at 6-monthly intervals to age 5 years. This research aims to describe the health, early learning and service context of these urban Aboriginal children from 5 to 9 years. Detailed longitudinal data on Aboriginal children's early life experiences have not previously been collected in an urban setting.
Closing The Gap: Early Childhood Sustained Home Visiting For Families Of Aboriginal Infants In An Urban Community
Funder
National Health and Medical Research Council
Funding Amount
$2,244,402.00
Summary
The study aims to determine whether a sustained structured nurse home visiting (SSNVH) program is effective for Aboriginal families. In the context of increased government investment in home visiting programs for Indigenous children, this study will help to answer three critical questions: (1) Does SSNHV result in improved outcomes for Aboriginal infants? (2) Is SSNHV equally effective for Aboriginal and non-Aboriginal infants?(3) What are the issues in adaptation and implementation?
Developing Evidence Based Strategies For Addressing Childhood Vaccination Rejection
Funder
National Health and Medical Research Council
Funding Amount
$743,927.00
Summary
Parental rejection of vaccines is a global concern that threatens to undermine disease control. A lack of evidence hampers the responses to this complex and persistent problem. We will interview parents who don’t vaccinate their children to learn what influences their decisions. We will then hold community juries and a public engagement process to refine strategies for responding to vaccination rejection that are acceptable to a well informed citizenry, practical and ethically justified.
Identifying Undiagnosed HIV Infection Among Australian Gay Men: Delivering HIV Testing Through A National, Community-based Study
Funder
National Health and Medical Research Council
Funding Amount
$781,432.00
Summary
Gay men remain the group primarily affected by HIV in Australia. People with undiagnosed HIV infection contribute disproportionately to HIV transmission in Australia. This study will deliver HIV testing to gay men in community settings, provide test results to consenting participants and estimate the prevalence of HIV and undiagnosed HIV infection. It will contribute significantly to reducing the number of undiagnosed HIV infections in Australia by providing strategic knowledge to guide HIV prev ....Gay men remain the group primarily affected by HIV in Australia. People with undiagnosed HIV infection contribute disproportionately to HIV transmission in Australia. This study will deliver HIV testing to gay men in community settings, provide test results to consenting participants and estimate the prevalence of HIV and undiagnosed HIV infection. It will contribute significantly to reducing the number of undiagnosed HIV infections in Australia by providing strategic knowledge to guide HIV prevention programs.Read moreRead less
WOmen's Action For Mums And Bubs (WOMB): A Pragmatic Trial Of Participatory Women's Groups To Improve Indigenous Maternal And Child Health
Funder
National Health and Medical Research Council
Funding Amount
$1,766,216.00
Summary
There is strong evidence elsewhere that involving community women in decision-making about strategies to improve the health of mothers and babies is a cheap and effective way of improving health. The WOMB study tests whether community women's groups improve the quality of maternal and child health care and outcomes in Aboriginal and Torres Strait Islander communities, the cost-effectiveness and how it works.
Tailored Activities To Reduce Challenging Behaviours In Persons With Dementia Living At Home: The TAP Trial
Funder
National Health and Medical Research Council
Summary
Dementia is the greatest single contributor to the burden of disability for older people. Challenging behaviours are common and associated with reduced quality of life for the person with dementia and the caregiver. The Tailored Activities Program, delivered by occupational therapists, is novel. It targets the capacity of the person with dementia and provides a systematic way to match both capacity and personal interest to activity. We will conduct a randomized trial to test its effectiveness.
Characterisation Of Eurl, A Novel Gene Implicated In The Etiology Of Abnormal Brain Development And Intellectual Disability
Funder
National Health and Medical Research Council
Funding Amount
$597,541.00
Summary
Intellectual disability affects around one per cent of Australians, and can arise from genetic abnormalities during fetal life, such as through abnormal regulation of gene expression. We have identified a novel gene, known as eurl, which controls brain assembly as well as the ability of neurons to form functional connections within the brain. We will investigate how this novel gene controls brain development, and characterise eurl as a potential therapeutic target for learning and memory.
Defining The Role Of The Ubiquitin Protein Ligase Nedd4 In Vascular Development.
Funder
National Health and Medical Research Council
Funding Amount
$702,166.00
Summary
Blood and lymphatic vessels are vital components of the cardiovascular system. Abnormalities in the growth and development of these vessels are associated with human disorders including cancer and cardiovascular disease. The focus of this application is to characterise the role of the ubiquitin protein ligase Nedd4 in vascular development, with the aim of identifying targets to which novel therapeutics for the treatment of blood and lymphatic vascular diseases could be generated.
Analysis Of Gene Regulation In Disorders Of Sex Development
Funder
National Health and Medical Research Council
Funding Amount
$524,852.00
Summary
Disorders of Sex Development (DSD) are surprisingly common, however the majority of cases still cannot be explained. Our hypothesis is that a significant proportion of DSD is due to disturbed gene regulation. We will use state of the art methods to analyse the regulation of DSD genes. Our research will improve our knowledge of the regulation of genes that affect DSD and provide a diagnosis for DSD patients for whom the underlying cause is unknown. This in turn will improve clinical management.