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Optimising disease surveillance to support decision-making. COVID-19 has demonstrated the critical role of epidemic data and analytics in guiding government response to pandemic threats, reducing disease and saving lives. The demand for epidemic analytics for response to threats of national significance will only grow. The goals of this project are to 1) determine the combination(s) of surveillance methods that provide the most useful data for epidemic analysis and 2) translate these findings in ....Optimising disease surveillance to support decision-making. COVID-19 has demonstrated the critical role of epidemic data and analytics in guiding government response to pandemic threats, reducing disease and saving lives. The demand for epidemic analytics for response to threats of national significance will only grow. The goals of this project are to 1) determine the combination(s) of surveillance methods that provide the most useful data for epidemic analysis and 2) translate these findings into the blueprint for a next-generation infectious disease surveillance system for Australia. We will use a simulation-evaluation approach, coupling methods from infectious disease modelling with those from information theory optimal design. Outcomes will enable more tailored and effective pandemic response.Read moreRead less
Do insect-specific flaviviruses regulate the transmission of mosquito-borne diseases in Australia? Mosquito-borne viral diseases such as dengue occur in Australia. The research team recently discovered related viruses in mosquitoes from Darwin that do not infect humans, but may inhibit the spread of viral diseases by mosquitoes. This project will investigate the life cycles of these new viruses to understand how they affect the spread of viral diseases by mosquitoes.
Revealing the evolutionary and ecological dynamics of avian influenza virus. This project aims to understand how avian influenza virus (AIV) emerges, evolves and spreads in wild birds. AIV has the potential to devastate the poultry industry and cause human pandemics, but the factors that shape the genetic diversity of AIV in its wild bird reservoir are poorly understood. The project plans to combine genomic, ecological and phylogenetic approaches to reveal key aspects of AIV evolution, as well a ....Revealing the evolutionary and ecological dynamics of avian influenza virus. This project aims to understand how avian influenza virus (AIV) emerges, evolves and spreads in wild birds. AIV has the potential to devastate the poultry industry and cause human pandemics, but the factors that shape the genetic diversity of AIV in its wild bird reservoir are poorly understood. The project plans to combine genomic, ecological and phylogenetic approaches to reveal key aspects of AIV evolution, as well as the risk for future viral emergence. Using sampling sites in Australia and Antarctica, it plans to investigate AIV diversity, the evolutionary dynamics of AIV in wild birds and poultry, and the role played by environmental transmission in AIV ecology.Read moreRead less
Understanding mutation and genetic reassortment in viruses: new mathematical models of viral dynamics and evolution. This project aims to understand how evolutionary processes and ecological conditions combine to ignite and sustain viral epidemics. Using novel mathematical models and statistical methods we will study the manner in which viral genes mutate and are recombined, as well as the rates of these important forces.
From shape to function: how structured RNA defines insect flaviviruses. The goal of this project is to obtain an understanding of how insect-specific flaviviruses (ISFs) utilise viral noncoding RNAs to enable their replication in mosquitoes. These viruses only replicate in mosquitoes, and not in humans or animals. They can be employed as the biocontrol agents for mosquito-borne diseases as they make mosquitoes incapable of disease transmission. However, it is currently unknown how exactly insect ....From shape to function: how structured RNA defines insect flaviviruses. The goal of this project is to obtain an understanding of how insect-specific flaviviruses (ISFs) utilise viral noncoding RNAs to enable their replication in mosquitoes. These viruses only replicate in mosquitoes, and not in humans or animals. They can be employed as the biocontrol agents for mosquito-borne diseases as they make mosquitoes incapable of disease transmission. However, it is currently unknown how exactly insect-specific flaviviruses affect mosquitoes and this information is vital for informed design of ISF-based interventions. The project will generate new knowledge on functions of noncoding RNAs in ISFs that are hypothesised to have immunomodulatory role in mosquitoes. It will also train students and ECRs.Read moreRead less
Addressing significant product safety knowledge gaps for older Australians . This project addresses significant gaps in contemporary knowledge of consumer product safety risks for older persons, with 25 years since the last Australian product safety research found older persons are at high risk of product-related injury/death. Products have evolved substantially and aged care models have changed in that time. This project generates contemporary knowledge of unsafe products causing injuries/death ....Addressing significant product safety knowledge gaps for older Australians . This project addresses significant gaps in contemporary knowledge of consumer product safety risks for older persons, with 25 years since the last Australian product safety research found older persons are at high risk of product-related injury/death. Products have evolved substantially and aged care models have changed in that time. This project generates contemporary knowledge of unsafe products causing injuries/deaths, risk factors/behaviours, and human rights issues. Outcomes benefiting the Australian community are improved prediction/characterisation of product safety issues for older Australians informing safer product design and use, targetted regulatory responses, ageing-in-place strategies, and creating safer home environments.Read moreRead less
Modulation of air-conditioning settings to destroy respiratory viruses. This project aims to prove that manipulating the ambient humidity can rapidly degrade airborne viruses. The relationship between ambient humidity and airborne infection is poorly understood for viral pathogens including influenza and the common cold. The project will prove that indoor environmental conditions can be easily manipulated to kill airborne viruses. The findings will be used to develop indoor air humidity control ....Modulation of air-conditioning settings to destroy respiratory viruses. This project aims to prove that manipulating the ambient humidity can rapidly degrade airborne viruses. The relationship between ambient humidity and airborne infection is poorly understood for viral pathogens including influenza and the common cold. The project will prove that indoor environmental conditions can be easily manipulated to kill airborne viruses. The findings will be used to develop indoor air humidity control guidelines targeting the vulnerabilities of the viruses to minimise airborne infection.Read moreRead less
Microbial natural history and molecular evolution. This project aims to develop mathematical and computational models of microbial evolution that capture dynamics at both within-host and between-host scales, combined with processes of mutation. Integration of these elements with computational statistical methods will produce a framework that will enable inference from genome sequencing data. The mathematical models will be applied to bacterial genomic data to investigate how natural selection ac ....Microbial natural history and molecular evolution. This project aims to develop mathematical and computational models of microbial evolution that capture dynamics at both within-host and between-host scales, combined with processes of mutation. Integration of these elements with computational statistical methods will produce a framework that will enable inference from genome sequencing data. The mathematical models will be applied to bacterial genomic data to investigate how natural selection acts on experimental and natural populations of microorganisms. The mathematical models and statistical approaches developed here are intended to be applicable to infectious disease of both humans and domesticated animals, and could influence public health policies.Read moreRead less
Combating HIV/AIDS in Indonesia: understanding the behaviour of sex workers and their clients. The aim of this project is to improve our understanding of the behaviour of sex workers and their clients in Indonesia, which has the fastest growing HIV epidemic in Asia. A comparison of the behavioural characteristics of sex workers and their clientele will tell us which groups are likely to be more responsive to particular types of policies.
New methods for integrating population structure and stochasticity into models of disease dynamics. Epidemics, such as the 2007 equine 'flu outbreak and 2009 swine 'flu pandemic, highlight the need to make informed decisive responses. This project will develop new methods that incorporate two important aspects of disease dynamics---host structure and chance---into mathematical models, and determine their impact in terms of controlling infections.