Characterisation Of The Molecular Mechanisms Mediating Aldosterone-induced Epithelial Electrolyte Transport
Funder
National Health and Medical Research Council
Funding Amount
$488,386.00
Summary
The steroid hormone aldosterone regulates blood pressure by controlling sodium retention. The importance of this role is underlined by the fact that all known mongenetic hypertensive conditions involve aldosterone or sodium retention. Aldosterone mediates this effect by activating an intracellular receptor protein that in turn switches on specific genes. This study seeks to identify the genes that are switched on (or off) by aldosterone and to characterise the region of the gene that interacts w ....The steroid hormone aldosterone regulates blood pressure by controlling sodium retention. The importance of this role is underlined by the fact that all known mongenetic hypertensive conditions involve aldosterone or sodium retention. Aldosterone mediates this effect by activating an intracellular receptor protein that in turn switches on specific genes. This study seeks to identify the genes that are switched on (or off) by aldosterone and to characterise the region of the gene that interacts with the receptor. Both cell and gene specific factors are thought to be important in defining the nature of this interaction; these factors will also be sought. This information will enhance our understanding of the basic biology of sodium transport in the colon and the kidney which in turn will clarify the role of aldosterone in high blood pressure, cardiac disease and perhaps even stress.Read moreRead less
IMMUNOPHILINS IN STEROID RECEPTOR- AND TISSUE-SPECIFIC ACTIONS: IMPLICATIONS FOR TREATMENT OF STEROID-BASED DISEASE
Funder
National Health and Medical Research Council
Funding Amount
$480,211.00
Summary
To convert steroid hormone signals in the cell steroid receptors rely on Hsp90 molecular chaperone machinery that is essential for receptor function and in particular 'helper' cohaperones that form part of receptor- Hsp90 complexes and fine-tune receptor responses to hormone. The present study addresses the fundamental role of the receptor helper' chaperone cyclophilin 40. Our study may have important implications for the treatment of steroid-based disease.