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The Role Of Membrane Condensation In T Lymphocyte Activation And Signal Transduction
Funder
National Health and Medical Research Council
Funding Amount
$82,421.00
Summary
T cell lymphocytes are essential cells in our immune system. They respond to signals from foreign bodies to mount an immune response. Many diseases arise from errors in their activation processes. The key steps in the translation of the initial arrival of a foreign-body to a T cell into an immune response will be examined in these studies, where we will look at the cooperation of components of the cell membrane during T cell activation. This will help us to understand and treat immune disorders.
Regulation Of Mesenchymal Stem Cell Paracrine Activity In Post-myocardial Infarction Cardiac Repair
Funder
National Health and Medical Research Council
Funding Amount
$73,212.00
Summary
Heart failure remains to be a major cause of morbidity in Australian population. After myocardial infarction, the damaged heart undergoes a series of compensatory adjustments to maintain the workload, termed cardiac remodeling. The resultant beneficial response in the short term eventually becomes deleterious. Using adult stem cells, the project aims to develop a better treatment to manipulate the progression of such responses and prevent hearts from entering the end stage heart failure.
Viability And Efficacy Of Implantable Biopolymer Based Anticonvulsant Delivery Systems In Rat Models Of Focal Epilepsy.
Funder
National Health and Medical Research Council
Funding Amount
$64,631.00
Summary
Recurrent seizures arising from abnormal brain activity are call epilepsy. Presently, epilepsy is treated using medicines by mouth. These often cause side effects affecting other body systems such as liver. Such effects can make patients ill or prevent them using particular drugs for epilepsy. Developing ways to deliver epilepsy medication directly to brain may allow better control of epileptic seizures with fewer side effects. We hope to develop a new such system using rats with epilepsy.
A Comparison Of Loaded And Unloaded Exercise For People With Non-specific Chronic Low Back Pain (NSCLBP)
Funder
National Health and Medical Research Council
Funding Amount
$42,410.00
Summary
Chronic low back pain is a common and costly condition. This research will conduct studies to determine the important ingredients of exercise programs that are related to successful outcomes for people with chronic low back pain (CLBP) and also to determine the effects of an exercise program intended to strengthen or load the low back muscles and a program that encourages movement restoration through movement not intended to strengthen for people with non-specific CLBP.
Signalling And Transcriptional Activity For Craniofacial Morphogenesis In An Experimental Genetic Mouse Model
Funder
National Health and Medical Research Council
Funding Amount
$74,755.00
Summary
Abnormalities in craniofacial development affect 2-1000 births in Australia. The aim of this project is to identify genes crucial for the development of the head and face. In particular the project focuses on the Twist1 gene. TWIST1 plays a key role in craniofacial development and individuals lacking functional Twist1display facial anomalies such as craniosynostosis and cleft palate. Dissecting the function of Twist1 is essential to identifying new avenues for the prevention of these defects.