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services including Reasearch Link Australia.
We will use the information you provide to improve the national research infrastructure and services we
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Infrastructure Strategy (NCRIS) program.
Please take a few minutes to provide your input. The survey closes COB Friday 29 May 2026.
Complete the 5 min survey now by clicking on the link below.
Molecular Mechanisms Of Protein Function And Pharmacology In Neuroscience And Cancer
Funder
National Health and Medical Research Council
Funding Amount
$876,005.00
Summary
I have been a Fellow 19 years. It allows me to think strategically on a broader canvass. I am a world authority in endocytosis (how cells interact with the outside world), drug discovery, and protein function, in disciplines of neuroscience and cancer. The outcome will be the first human trials of endocytosis modulators in cancer and epilepsy. Secondly, we will use our new International ProCan Centre to produce a transformational rapid cancer diagnostic and provide new cancer treatment options.
Neurobiology Of Schizophrenia And Translation Into New Treatments
Funder
National Health and Medical Research Council
Funding Amount
$763,845.00
Summary
We need to discover novel pharmacological therapies that operate on pathways beyond DAD2R, that will be more effective and have fewer side effects. To identify such agents, we need a better understanding of the biological basis of schizophrenia.
I am a cartilage biochemist investigating (1) cartilage remodelling in normal skeletal growth & development and (2) the molecular events that destroy cartilage in arthritic diseases. My research focuses on the molecules that define cartilage structure, and the enzymes that degrade and remodel it. Our analyses include work with molecules in test tubes, genetically modified mice with degradation-resistant cartilage, and synovial fluid samples from arthritis patients.
Enhancing Disease Vector Biosecurity Through High Density Molecular Markers
Funder
National Health and Medical Research Council
Funding Amount
$763,845.00
Summary
The outbreak of several diseases spread by mosquitoes is increasing rapidly around the world, driven by increased people movement spreading both viruses and disease vectors, a lack of effective vaccines and changing climatic conditions. In this proposal I aim to develop cutting edge molecular tools for identifying pathways of exotic mosquito introductions into Australia and a program that uses bacteria living inside mosquitoes in novel ways for disease suppression.
Translational Genomics And Combinatorial Drug Discovery To Improve Outcomes For Patients With Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$640,210.00
Summary
Bowel cancer is a major public health burden in Australia. Over the next 5 years, A/Prof Sieber’s research will focus on understanding the molecular pathology of bowel cancer and how this determines the course of disease and response to therapy. Integrated genomic, functional and drug discovery studies will provide significant new insights into fundamental tumour biology and open up new avenues for diagnosis and treatment.
The Molecular Mechanisms Of Inherited And Acquired Musculoskeletal Disease
Funder
National Health and Medical Research Council
Funding Amount
$823,008.00
Summary
Diseases of the musculoskeletal system are the second most prevalent medical conditions, and the second leading cause of health care expenditure in Australia. This research program seeks to identify genes causing inherited musculoskeletal disease and osteoarthritis. By identifying these genes, and by understanding the detailed molecular mechanisms of how gene mutations cause these disorders, our research is working towards developing better diagnostic and therapeutic approaches
Developmental Neurobiology Of Schizophrenia And Translation Into New Treatments
Funder
National Health and Medical Research Council
Funding Amount
$611,574.00
Summary
Our ultimate goal is to expand effective treatment options for people with schizophrenia particularly ones that can prevent schizophrenia from developing. The successful completion of this project will identify novel biological pathways by which schizophrenia develops and, importantly, will yield new molecular tools to personalise treatment of schizophrenia.
Applying Next Generation Sequencing To Family Studies
Funder
National Health and Medical Research Council
Funding Amount
$182,622.00
Summary
Recent advances in technology can determine the DNA composition of a person for much longer stretches of DNA, at a much cheaper cost. I use statistical analysis to identify regions of the human genome that harbour mutations that cause diseases such as epilepsy in families. These regions contain 5-15 million base pairs. We need to find the ONE base pair that causes disease. This application deals with the development of new tools to exploit new technology for the identification of mutations.