Functional impact of high fat and high sugar diets on memory encoding. This project aims to determine the functional mechanisms of how fats and sugar affect neuronal processes vital for learning and memory. Expected outcomes will define the neural mechanisms underpinning cognitive changes in emotional and spatial memory encoding, and how these relate to brain and metabolic parameters. This will provide benefits by unveiling the possible consequences of dietary fat and sugar on the brain, and th ....Functional impact of high fat and high sugar diets on memory encoding. This project aims to determine the functional mechanisms of how fats and sugar affect neuronal processes vital for learning and memory. Expected outcomes will define the neural mechanisms underpinning cognitive changes in emotional and spatial memory encoding, and how these relate to brain and metabolic parameters. This will provide benefits by unveiling the possible consequences of dietary fat and sugar on the brain, and the mechanisms of neuroplasticity enhancing interventions.Read moreRead less
Paving the way for ultra-long haul flights: strategies to mitigate jetlag. This project aims to develop and test strategies to mitigate jetlag, founded on biophysical modelling of circadian rhythms. It sets out to quantify the speed of circadian adaptation of sleep, alertness, and metabolism after transmeridian travel and to maximise speed of adaptation via optimised timing of light exposure, food, and exercise in-flight and on-the-ground. Expected outcomes include powerful models for jetlag str ....Paving the way for ultra-long haul flights: strategies to mitigate jetlag. This project aims to develop and test strategies to mitigate jetlag, founded on biophysical modelling of circadian rhythms. It sets out to quantify the speed of circadian adaptation of sleep, alertness, and metabolism after transmeridian travel and to maximise speed of adaptation via optimised timing of light exposure, food, and exercise in-flight and on-the-ground. Expected outcomes include powerful models for jetlag strategies, ready for application in air travel. The project will directly inform Qantas’ operations for ultra-long haul flights and their international network more broadly. Project outcomes will benefit society and the economy through improving travellers’ alertness, sleep, and reducing the risk of fatigue-related accidents.Read moreRead less
Circadian photoreceptor sensitivity and impacts of modern lighting on sleep. Light has powerful non-visual effects, including effects on sleep. These non-visual effects are mediated by cells in the eye that are most sensitive to blue light. There are large individual differences in sensitivity to non-visual effects of light that are not understood and that would give great insight into suboptimal sleep, which has become widespread in modern society. This study will be the first systematic examin ....Circadian photoreceptor sensitivity and impacts of modern lighting on sleep. Light has powerful non-visual effects, including effects on sleep. These non-visual effects are mediated by cells in the eye that are most sensitive to blue light. There are large individual differences in sensitivity to non-visual effects of light that are not understood and that would give great insight into suboptimal sleep, which has become widespread in modern society. This study will be the first systematic examination of individual differences in the effect of blue light on sleep and will uncover how alterations in the gene responsible for the effects of blue light on sleep (OPN4) contribute to these differences. This will lead to scalable individualised solutions to the unmet problem of how modern light environments impact sleep.Read moreRead less
Hunger flexibly modifies hypothalamic neural circuits responding to threat. Animal and human behaviour frequently involves a choice between actions or goals with conflicting positive and negative outcomes. However, the appropriate action or goal in conflicting situations often depends on physiological pressures like hunger, stress and mating opportunities. For example, the need for resources within an environment, such as food, drives approach behaviour, whereas threats to survival, such as pred ....Hunger flexibly modifies hypothalamic neural circuits responding to threat. Animal and human behaviour frequently involves a choice between actions or goals with conflicting positive and negative outcomes. However, the appropriate action or goal in conflicting situations often depends on physiological pressures like hunger, stress and mating opportunities. For example, the need for resources within an environment, such as food, drives approach behaviour, whereas threats to survival, such as predator cues, enhance avoidance behaviour. This project will uncover the neural circuitry and endocrine mechanisms through which hunger influences hypothalamic threat-detecting circuits that suppress food intake. These studies provide a new hypothalamic model to understand risk/reward decision in the brain.Read moreRead less
Detecting and tracking alertness using speech biometrics. Traditional tests for detecting and tracking alertness are limited by their accuracy and inability to be administered without stopping work. This project aims to investigate how speech can be used to monitor changes in performance resulting from sleep deprivation and successive night shifts. The expected outcomes are 1) new knowledge on how sensitive speech and language features are for detecting change in alertness, and 2) development an ....Detecting and tracking alertness using speech biometrics. Traditional tests for detecting and tracking alertness are limited by their accuracy and inability to be administered without stopping work. This project aims to investigate how speech can be used to monitor changes in performance resulting from sleep deprivation and successive night shifts. The expected outcomes are 1) new knowledge on how sensitive speech and language features are for detecting change in alertness, and 2) development and verification of a highly accurate, cost-effective, speech focussed assay capable of detecting impaired alertness from otherwise healthy individuals. The project should benefit the way fitness for duty is tested and provide new methods for safeguarding Australians working in at-risk environments.Read moreRead less
Evaluating the Quality of Scientific Research in Psychology. Buttressing public trust in science has never been more important, yet many sciences are experiencing a crisis of confidence. The current system of relying on journal prestige to calibrate our confidence in individual research findings has created corrupt incentives for scientists, and risks undermining public trust in science. Thousands of scientists and institutions around the world have indicated that research evaluation needs an ov ....Evaluating the Quality of Scientific Research in Psychology. Buttressing public trust in science has never been more important, yet many sciences are experiencing a crisis of confidence. The current system of relying on journal prestige to calibrate our confidence in individual research findings has created corrupt incentives for scientists, and risks undermining public trust in science. Thousands of scientists and institutions around the world have indicated that research evaluation needs an overhaul by signing the Declaration on Research Assessment. One solution is to create a public, transparent, and valid process for producing and sharing expert evaluations of individual papers. This project aims to launch this reform in psychology, and partner with PREreview to help it spread to other fields.Read moreRead less
Econometric studies of the dynamics of loneliness and social isolation. This project aims to provide new insights into the socioeconomic dynamics of loneliness and social isolation using advanced econometric modelling techniques applied to longitudinal data from Australia and the UK. This project will apply advanced econometric modelling techniques to data from four nationally-representative longitudinal surveys to substantively help address these knowledge gaps, giving policy-makers new informa ....Econometric studies of the dynamics of loneliness and social isolation. This project aims to provide new insights into the socioeconomic dynamics of loneliness and social isolation using advanced econometric modelling techniques applied to longitudinal data from Australia and the UK. This project will apply advanced econometric modelling techniques to data from four nationally-representative longitudinal surveys to substantively help address these knowledge gaps, giving policy-makers new information about how to address these growing societal concerns. The expected outcomes will provide policy-makers with a better understanding of the socioeconomic triggers for loneliness and social isolation; quantify the costs of loneliness and social isolation on health and wellbeing; and identify policy interventions aimed at reducing loneliness and social isolation.Read moreRead less
The desire for knowledge: Neural mechanisms of information-seeking. This project aims to determine the mechanisms that drive individuals to seek out information, and to characterise the neural processes that underlie how that information is valued. The project tests the idea that information is represented in the brain as a form of reward. The results are expected to contribute significant mechanistic insights at the level of brain and behaviour on the nature of information value. This is likely ....The desire for knowledge: Neural mechanisms of information-seeking. This project aims to determine the mechanisms that drive individuals to seek out information, and to characterise the neural processes that underlie how that information is valued. The project tests the idea that information is represented in the brain as a form of reward. The results are expected to contribute significant mechanistic insights at the level of brain and behaviour on the nature of information value. This is likely to have wide-ranging implications across multiple domains of human endeavour, including education, work-place efficiency, policy development, and consumer behaviour.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220101508
Funder
Australian Research Council
Funding Amount
$447,000.00
Summary
A Brain-Behaviour Model of Decision-Making Under Distraction. People make thousands of decisions each day, such as judging whether it is safe to cross the street at a busy intersection. This project aims to investigate how decision-making is impacted when a person is temporarily distracted, for example when receiving a text message alert from one’s phone. By combining recordings of brain activity with cutting-edge mathematical modelling techniques, this project expects to develop a novel theoret ....A Brain-Behaviour Model of Decision-Making Under Distraction. People make thousands of decisions each day, such as judging whether it is safe to cross the street at a busy intersection. This project aims to investigate how decision-making is impacted when a person is temporarily distracted, for example when receiving a text message alert from one’s phone. By combining recordings of brain activity with cutting-edge mathematical modelling techniques, this project expects to develop a novel theoretical framework that captures the effects of distraction on brain networks that underpin human decision-making performance. This knowledge should be highly beneficial for developing informed policies that reduce effects of distraction and preserve decision-making capacity in safety critical situations.Read moreRead less
Addressing Evidence Gaps And Developing A Novel Treatment To Reduce The Burden Of Post-traumatic Knee Osteoarthritis
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Arthritis caused by knee injury has a devastating personal and economic impact. Research is needed to develop strategies to prevent arthritis and improve outcomes for people living with arthritis. This research will improve treatment of knee injury to reduce arthritis risk, understand why some people are more likely to get knee arthritis, and develop a new treatment to improve outcomes for people living with knee arthritis. A clinical trial will determine if this treatment achieves this aim.