An Investigation Into The Neural Substrates Of Cognitive Deficits In Mild Cognitive Impairment, And The Mechanisms Of Action Of A Novel Treatment
Funder
National Health and Medical Research Council
Funding Amount
$574,644.00
Summary
Furthering our understanding of the brain mechanisms that underlie the deficits in memory, executive function, and language that occur with Mild Cognitive Impairment is vital for conceptualising the underlying disease processes, and for the development of targeted treatments. Hence, this project will conduct a comprehensive assessment of the brain’s electrical and metabolic responses during specialised cognitive tasks, whilst simultaneously investigating a possible treatment.
Cross-comparison, Validation And Performance Of Computerised Neuropsychological Assessment Devices In The Evaluation Of Mild Cognitive Impairment And Dementia
Funder
National Health and Medical Research Council
Funding Amount
$700,482.00
Summary
With an ageing population and associated increase in dementia there will be increased demand for neuropsychological assessment, with insufficient trained personnel and resources to meet this demand. Computerised tests offer excellent opportunities for large scale implementation of cognitive screening and monitoring of older adults. This is the first study to systematically evaluate and compare several popular computerised neuropsychological assessment devices in elders with and without dementia.
Ageing And Dementia In Aboriginal Australians: Promoting Vitality, Identifying Decline And Supporting Communities
Funder
National Health and Medical Research Council
Funding Amount
$603,411.00
Summary
Dementia is a growing concern and burden on communities for Aboriginal Australians. This fellowship will develop effective, culturally appropriate, and accessible strategies to promote healthy brain ageing and prevent dementia in Aboriginal communities. It will also investigate better ways to assess memory and thinking in this population, in order to identify changes as early as possible for enhanced dementia research and treatment prospects.
Altered Sense Of Identity In Dementia: Cognitive And Neurobiological Underpinnings
Funder
National Health and Medical Research Council
Funding Amount
$108,902.00
Summary
People with dementia commonly experience changes in their sense of identity, causing significant distress for the individual and their families. This project will investigate these changes comprehensively, determining their contributing factors and how they relate to dementia’s effect on the brain. Outcomes from this project will improve understanding of the experience of the person with dementia, informing personalised care and enhancing the quality of patient-carer relationships.
The effect of temperature biofeedback on sleep and cardiac autonomic tone in young and aged adults. Peripheral heat loss is reported to promote sleep onset. To date, however, most studies examining the thermoregulatory model of sleep onset have used sedative-hypnotics with both thermoregulatory and soporific effects. We propose that a better test of a causal relationship between peripheral heat loss and sleep can be achieved by using temperature biofeedback; a promising non-invasive and non-dr ....The effect of temperature biofeedback on sleep and cardiac autonomic tone in young and aged adults. Peripheral heat loss is reported to promote sleep onset. To date, however, most studies examining the thermoregulatory model of sleep onset have used sedative-hypnotics with both thermoregulatory and soporific effects. We propose that a better test of a causal relationship between peripheral heat loss and sleep can be achieved by using temperature biofeedback; a promising non-invasive and non-drug treatment that does not have a direct effect on sleep structures. We aim to test whether increased peripheral heat loss promotes sleep onset, whether the effects are mediated by changes in autonomic tone, and whether this relationship changes with age.Read moreRead less
A developmental and neural analysis of learned and unlearned fear. This project aims to increase our understanding of the emotion of fear from both a developmental and a neural perspective. Anxiety disorders, which are characterised by the inability to appropriately regulate fear, are among the most prevelant psychological disturbances in industrialised countries. The present project involves a neurobiological analysis of fear in the developing rat, and will (i) test the dominant theoretical mod ....A developmental and neural analysis of learned and unlearned fear. This project aims to increase our understanding of the emotion of fear from both a developmental and a neural perspective. Anxiety disorders, which are characterised by the inability to appropriately regulate fear, are among the most prevelant psychological disturbances in industrialised countries. The present project involves a neurobiological analysis of fear in the developing rat, and will (i) test the dominant theoretical models of learned fear, (ii) compare the development of learned and unlearned fear, and (iii) provide a novel approach for studying whether learned behavioural responses are appropriate to the age of training or the age of testing.Read moreRead less
The desire for knowledge: Neural mechanisms of information-seeking. This project aims to determine the mechanisms that drive individuals to seek out information, and to characterise the neural processes that underlie how that information is valued. The project tests the idea that information is represented in the brain as a form of reward. The results are expected to contribute significant mechanistic insights at the level of brain and behaviour on the nature of information value. This is likely ....The desire for knowledge: Neural mechanisms of information-seeking. This project aims to determine the mechanisms that drive individuals to seek out information, and to characterise the neural processes that underlie how that information is valued. The project tests the idea that information is represented in the brain as a form of reward. The results are expected to contribute significant mechanistic insights at the level of brain and behaviour on the nature of information value. This is likely to have wide-ranging implications across multiple domains of human endeavour, including education, work-place efficiency, policy development, and consumer behaviour.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220101508
Funder
Australian Research Council
Funding Amount
$447,000.00
Summary
A Brain-Behaviour Model of Decision-Making Under Distraction. People make thousands of decisions each day, such as judging whether it is safe to cross the street at a busy intersection. This project aims to investigate how decision-making is impacted when a person is temporarily distracted, for example when receiving a text message alert from one’s phone. By combining recordings of brain activity with cutting-edge mathematical modelling techniques, this project expects to develop a novel theoret ....A Brain-Behaviour Model of Decision-Making Under Distraction. People make thousands of decisions each day, such as judging whether it is safe to cross the street at a busy intersection. This project aims to investigate how decision-making is impacted when a person is temporarily distracted, for example when receiving a text message alert from one’s phone. By combining recordings of brain activity with cutting-edge mathematical modelling techniques, this project expects to develop a novel theoretical framework that captures the effects of distraction on brain networks that underpin human decision-making performance. This knowledge should be highly beneficial for developing informed policies that reduce effects of distraction and preserve decision-making capacity in safety critical situations.Read moreRead less