Neural noise in human cognitive ageing and reserve. Age-related increases in neural noise degrade information transfer in the brain and lead to diminished cognitive function. Yet with cognitive reserve, some people are able to maintain healthy functioning well into their later years. This project aims to investigate the effects of neural noise on brain connectivity, cognitive performance and reserve, advancing breakthrough work on the neural physiology of healthy cognitive ageing and malleabilit ....Neural noise in human cognitive ageing and reserve. Age-related increases in neural noise degrade information transfer in the brain and lead to diminished cognitive function. Yet with cognitive reserve, some people are able to maintain healthy functioning well into their later years. This project aims to investigate the effects of neural noise on brain connectivity, cognitive performance and reserve, advancing breakthrough work on the neural physiology of healthy cognitive ageing and malleability of neural noise. This will be delivered by novel combinations of electrophysiology, neuroimaging and non-invasive brain stimulation. Benefits extend from developing neural markers for measuring cognitive reserve to new strategies for building resilience to age-related cognitive decline.Read moreRead less
How is information organised in the mind? Learning structured mental representations from data. One of the biggest questions in psychology is to understand the principles that the mind uses to organise information. This project is both a search for these underlying psychological laws, and an attempt to develop new statistical technologies and mathematical tools that can be used to organise information in applied settings.
Using language to predict cognitive outcomes in old age. This project aims to understand the relationship between linguistic complexity metrics and cognitive decline in old age. The project will test the hypothesis that high linguistic complexity scores reflect the ability to strategically optimise processing in the face of age-related reductions in processing capacity. By studying the relation between complexity scores and real-time information processing (measured via electroencephalography) a ....Using language to predict cognitive outcomes in old age. This project aims to understand the relationship between linguistic complexity metrics and cognitive decline in old age. The project will test the hypothesis that high linguistic complexity scores reflect the ability to strategically optimise processing in the face of age-related reductions in processing capacity. By studying the relation between complexity scores and real-time information processing (measured via electroencephalography) across the adult lifespan (20–80 years), this project will develop a simple and accurate marker of the individual balance between processing capacity and strategy. This project has the potential to increase quality of life for the elderly and reduce costs of age-related cognitive impairment.Read moreRead less
Social relations and social engagement in older adulthood: implications for health, well being and cognition. This project will examine the nature of changes in peoples social networks that occur with age and the effects of these changes on health and well being in later life. The project will use information collected as part of several ongoing Australian studies of ageing and will have implications for social policy.
Normal heart development before birth. This project aims to understand how the fetal heart can develop normally with much less oxygen than an adult heart uses. Regulation of fetal heart proliferation is not well understood but changes in oxygen levels and non-coding RNAs are implicated. Using advanced imaging techniques to measure blood flow in blood vessels to the fetal heart and molecular probes to assess cell function and microarrays to measure non-coding RNA, the project expects to generate ....Normal heart development before birth. This project aims to understand how the fetal heart can develop normally with much less oxygen than an adult heart uses. Regulation of fetal heart proliferation is not well understood but changes in oxygen levels and non-coding RNAs are implicated. Using advanced imaging techniques to measure blood flow in blood vessels to the fetal heart and molecular probes to assess cell function and microarrays to measure non-coding RNA, the project expects to generate new knowledge about mechanisms of fetal heart cell proliferation. Ultimately, this new knowledge could lead to non-invasive approaches to detect and treat abnormal fetal heart growth in animals and humans.Read moreRead less
DNA and the missing: ancient DNA and advanced forensic identification. Identifying the remains of missing persons, disaster victims and war dead is of major social and cultural importance and has significant implications for national and international justice systems. This project will apply expertise in analysis of ancient DNA to build capacity and expertise within Australia to identify highly degraded human remains.
Changing patterns of migration from Afghanistan with implications for Australia. As a signatory to the UN Refugee Convention, a major location for the resettlement of refugees and a major player in the international system with a stated commitment to humanitarian issues, Australia is well placed to play a lead role in promoting more effective solutions to the plight of refugees. This study is designed to contribute to that objective through research of one of the world's most important refugee g ....Changing patterns of migration from Afghanistan with implications for Australia. As a signatory to the UN Refugee Convention, a major location for the resettlement of refugees and a major player in the international system with a stated commitment to humanitarian issues, Australia is well placed to play a lead role in promoting more effective solutions to the plight of refugees. This study is designed to contribute to that objective through research of one of the world's most important refugee groups, the Afghans. It will also provide a better understanding of the security issues involved in refugee migration.Read moreRead less
The molecular interactome and functions of circular RNAs. This project aims to identify the functions of circular RNAs, the most contemporary and enigmatic family of RNA molecules. While their abundance suggests they are important, it is unclear how they function at the molecular level. This project aims to delineate circular RNA function by systematically identifying their interacting partners at the DNA, RNA and protein levels, the so-called molecular interactome. This project will reprogram e ....The molecular interactome and functions of circular RNAs. This project aims to identify the functions of circular RNAs, the most contemporary and enigmatic family of RNA molecules. While their abundance suggests they are important, it is unclear how they function at the molecular level. This project aims to delineate circular RNA function by systematically identifying their interacting partners at the DNA, RNA and protein levels, the so-called molecular interactome. This project will reprogram embryonic stem cells to model developmental processes and is designed to validate circular RNA research. Together, the benefits include a higher-quality research workforce by mentoring students, refining fundamental tenets of RNA biology and may extend to improving health in the long-term.Read moreRead less
The transcriptional control of lymphatic vessel development. Lymphatic vessels are a vital, but often overlooked, component of the cardiovascular system. These specialised vessels return tissue fluid to the bloodstream, absorb dietary lipids and transport cells of the immune system throughout the body. Defects in the growth and development of lymphatic vessels result in disorders including lymphedema, obesity, inflammatory diseases and cancer. This project aims to define how transcription factor ....The transcriptional control of lymphatic vessel development. Lymphatic vessels are a vital, but often overlooked, component of the cardiovascular system. These specialised vessels return tissue fluid to the bloodstream, absorb dietary lipids and transport cells of the immune system throughout the body. Defects in the growth and development of lymphatic vessels result in disorders including lymphedema, obesity, inflammatory diseases and cancer. This project aims to define how transcription factors program lymphatic vessel identity and control the development of lymphatic vessel valves. This knowledge will provide new insight into the fundamental mechanisms by which the lymphatic vasculature is constructed during development.Read moreRead less
Realising socio-economic rights: law and the politics of access to public services in Indonesia. This project seeks to identify the conditions under which justiciable legal frameworks or socio-economic rights are effective in promoting realisation of these rights in developing countries. The empirical focus is on Indonesia during the post-Suharto era and rights related to free basic education, water, and free health care for the poor.