Prevention Of Adverse Child Behavioural Development Following Maternal Depression In Pregnancy
Funder
National Health and Medical Research Council
Funding Amount
$761,937.00
Summary
There is good evidence that if a woman is depressed while pregnant, her child is substantially more likely to have later emotional or behavioural problems. We will evaluate whether child outcomes following maternal depression in pregnancy can be improved by antenatal depression treatment. Our objective is to protect fetal and child development from the adverse developmental outcomes associated with untreated depression.
Intervention Trial To Reduce Alcohol Related Harms Among High Risk Young Indigenous Australians
Funder
National Health and Medical Research Council
Funding Amount
$392,553.00
Summary
Indigenous Australians experience disproportionately high rates of drug and alcohol harms and young people are particularly vulnerable: over 50% of 10-17 year old juvenile detainees are Indigenous, despite comprising only 2% of the population. There is no reliable evidence about which interventions might reduce these harms. This study quantifies the benefits/costs of combining cognitive-behaviour therapy with a community-reinforcement strategy to reduce substance-related harms among young Indige ....Indigenous Australians experience disproportionately high rates of drug and alcohol harms and young people are particularly vulnerable: over 50% of 10-17 year old juvenile detainees are Indigenous, despite comprising only 2% of the population. There is no reliable evidence about which interventions might reduce these harms. This study quantifies the benefits/costs of combining cognitive-behaviour therapy with a community-reinforcement strategy to reduce substance-related harms among young Indigenous Australians.Read moreRead less
The Alert Program: An Evidence Based Treatment Program For Aboriginal Children Living With FASD (Fetal Alcohol Spectrum Disorder)
Funder
National Health and Medical Research Council
Funding Amount
$1,196,940.00
Summary
This study will research the effectiveness of the Alert Program to improve self-regulation and executive functioning skills in primary school aged children in the Fitzroy Valley, a vast area located within the Kimberley region of Western Australia. The project also aims to document a sustainable and culturally appropriate method of implementing a theraputic intervention that supports the improvement of skills in children living with fetal alcohol spectrum disorders within these communities.
Outcomes From A Multi-site Randomised Controlled Trial Comparing Regional And General Anaesthesia For Effects On Neurodevelopmental Outcome And Apnoea In Infants
Funder
National Health and Medical Research Council
Funding Amount
$757,831.00
Summary
Animal studies suggest general anaesthetics harm the developing brain. It is unclear if these findings are relevant to humans. The aim of this international randomised controlled trial is to determine whether children exposed to general anaesthesia as an infant have a poorer neurodevelopmental outcome. A previous NHMRC grant funded the first phase of the trial along with substantial funding from overseas. The trial will tell us if general anaesthetics affect the developing brain in children.
Effect Of High Dose Infant Fish Oil Supplementation And FADS 1 & 2 Genetic Polymorphisms On Cognitive Development And School Giftedness
Funder
National Health and Medical Research Council
Funding Amount
$325,938.00
Summary
This project will investigate the influence of fish oil supplementation during the first six months of life on intelligence, language, behaviour and school performance at age six. We will also investigate how genetic differences in fish oil metabolism can impact upon these relationships. The findings will enhance our knowledge pertaining to the potential benefits of fish oil on cognitive development, and will inform future practice regarding the high dose fortification of infant formula.
Do Ongoing Cognitive Demands Affect The Efficacy Of Transcranial Electrical Brain Stimulation In Young And Older Healthy Adults?
Funder
National Health and Medical Research Council
Funding Amount
$627,857.00
Summary
Transcranial direct current stimulation (tDCS) of the brain is widely used to enhance cognitive and motor function in healthy individuals and people with neurological disorders. Unfortunately, the efficacy of tDCS is highly variable between individuals. This project tests the hypothesis that ongoing cognitive processes – particularly attention – play an important role in regulating the effect of tDCS on brain function. The knowledge gained will help refine tDCS as a clinical and research tool.
A Novel, Technology-based Program Targeting Physical, Cognitive And Mental Well-being To Maximise Fall Prevention In Older People: An Evidence-based Multifactorial Approach
Funder
National Health and Medical Research Council
Funding Amount
$1,475,781.00
Summary
Accidental falling among older people is a significant public health challenge worldwide. This study addresses a key gap in the translation of available evidence to prevent falls in older people more effectively. The proposed trial will provide the first-ever evidence about the cost and effectiveness of a tailored multifactorial fall prevention program using technology and self-management principles.
Gene-environment Interactions Modulating Cortical And Cognitive Dysfunction
Funder
National Health and Medical Research Council
Funding Amount
$618,300.00
Summary
A feature of many major brain disorders, including schizophrenia and dementia, is disruption of cognition. A key brain area impacted in such cognitive disorders is the prefrontal cortex. This project will use clinically translatable touchscreen to understand how this aspect of brain dysfunction causes abnormal cognition. We will investigate the mechanisms involved, using highly innovative approaches, which will contribute to the development of new treatments for such cognitive disorders.
Are Healthcare Interventions Exacerbating Alzheimer's Disease (AHEAD)
Funder
National Health and Medical Research Council
Funding Amount
$709,803.00
Summary
The AHEAD Study will assess the impact of anaesthesia and surgery on cognitive function in patients with Mild Cognitive Impairment or mild Alzheimer's Disease. Such effects have not been established. With an ageing population being increasingly exposed to healthcare procedures requiring anaesthesia or sedation, any negative impact needs to be identified so that therapeutic decisions may be informed and future research appropriately targeted.
Enhancing The Treatment Of Anxiety: The Role Of Mental Imagery
Funder
National Health and Medical Research Council
Funding Amount
$246,491.00
Summary
This proposal will conduct the first pre-clinical study augmenting the effectiveness of cognitive behaviour therapy (CBT) in the treatment of anxiety disorders using mental imagery. There is an urgent need to develop means to increase the success rate of CBT. This study will utilise recent developments in cognitive neuroscience to show that mental imagery plays an important role in the mechanisms of CBT.