Intracortical inhibition evaluated by paired-pulse TMS during choice and simple reaction time tasks. The research will investigate the neurophysiological processes responsible for the selection and initiation of movement in response to an external stimulus. Slowness in the initiation and execution of movement is a common feature of 'neurological aging', neurodegenerative disease, and brain injury. Understanding the brain mechanisms involved in response selection and movement initiation will pro ....Intracortical inhibition evaluated by paired-pulse TMS during choice and simple reaction time tasks. The research will investigate the neurophysiological processes responsible for the selection and initiation of movement in response to an external stimulus. Slowness in the initiation and execution of movement is a common feature of 'neurological aging', neurodegenerative disease, and brain injury. Understanding the brain mechanisms involved in response selection and movement initiation will provide information for the development of specific intervention techniques to improve motor function in these groups.Read moreRead less
Neural correlates of performance trade-offs and interference in dual-task performance. Our daily lives are characterised by our ability to produce and sustain a wide range of different movement patterns and to deliberately change patterns as the situation demands. In this project we seek to understand the relationship between brain processes, attentional demands, and the control and learning of coordinated behaviour. A further aim will be to examine how this relationship may be altered as a re ....Neural correlates of performance trade-offs and interference in dual-task performance. Our daily lives are characterised by our ability to produce and sustain a wide range of different movement patterns and to deliberately change patterns as the situation demands. In this project we seek to understand the relationship between brain processes, attentional demands, and the control and learning of coordinated behaviour. A further aim will be to examine how this relationship may be altered as a result of aging, degenerative disease, or brain damage. This research will provide a foundation upon which rehabilitation strategies can be developed for the movement impaired.Read moreRead less
Assessment of Executive Function in Children and Adults. This project aims to develop tests for executive function that are better grounded in the theory of cognitive processes, have sound measurement properties, and are more efficient, than existing measures. Executive functions entail planning, self-evaluation and adaptation to novel situations. Executive function deficits are found in children and adults who have suffered injury to the frontal regions of the brain, in some ageing adults, and ....Assessment of Executive Function in Children and Adults. This project aims to develop tests for executive function that are better grounded in the theory of cognitive processes, have sound measurement properties, and are more efficient, than existing measures. Executive functions entail planning, self-evaluation and adaptation to novel situations. Executive function deficits are found in children and adults who have suffered injury to the frontal regions of the brain, in some ageing adults, and in certain clinical groups such as autistics. Ability to cope with complexity is a factor in executive functioning, and this will be assessed utilising a new approach to analysis of cognitive complexity.Read moreRead less
How does Motor Cortex Excitability Influence Internal Model Retention. Each year 40,000 Australians suffer from stroke with many survivors left with problems that limit limb function. With reduced duration of hospital care, the opportunities for retraining in the period immediate following stroke are rapidly diminishing. Effective and efficient strategies of rehabilitation that will maximise the level of recovery following stroke will result in benefits expressed in terms of enhanced quality of ....How does Motor Cortex Excitability Influence Internal Model Retention. Each year 40,000 Australians suffer from stroke with many survivors left with problems that limit limb function. With reduced duration of hospital care, the opportunities for retraining in the period immediate following stroke are rapidly diminishing. Effective and efficient strategies of rehabilitation that will maximise the level of recovery following stroke will result in benefits expressed in terms of enhanced quality of life and functional life-span, as well as significantly reduced costs of health care. In understanding the fundamental principles underlying the stability and adaptability of movement coordination, this research is likely to make a significant contribution to the design of programs for rehabilitation of the upper limb.Read moreRead less
Facilitatory and inhibitory mechanisms during interlimb coordination in young and older adults. The project seeks to understand how people coordinate their limbs and the factors which limit and enhance this capacity. This is of critical importance because coordination is a dominant deficit in aging and in patients suffering brain insult and neurodegenerative diseases. Disruption of this capacity compromises individual work productivity, mobility and independence. Proficient motor functioning is ....Facilitatory and inhibitory mechanisms during interlimb coordination in young and older adults. The project seeks to understand how people coordinate their limbs and the factors which limit and enhance this capacity. This is of critical importance because coordination is a dominant deficit in aging and in patients suffering brain insult and neurodegenerative diseases. Disruption of this capacity compromises individual work productivity, mobility and independence. Proficient motor functioning is an important lifestyle factor as humans age and deficits in coordinated muscle activity will increase the risk of falls which are the leading cause of injury in elderly adults. Identification of changes in brain processes involved in interlimb coordination will allow for the development of strategies to improve motor functions in the aged.Read moreRead less
Interlimb coordination dynamics in stroke. Everyday we use our limbs in a coordinated manner. However, for a person who has suffered a stroke resulting in weakness on one side of the body even the simplest interlimb coordination tasks are difficult to perform. This project will examine interlimb coordination in persons who have suffered a stroke and explore whether the coupling between limbs can be exploited to promote fuctional recovery of an impaired limb. In particular, the research seeks to ....Interlimb coordination dynamics in stroke. Everyday we use our limbs in a coordinated manner. However, for a person who has suffered a stroke resulting in weakness on one side of the body even the simplest interlimb coordination tasks are difficult to perform. This project will examine interlimb coordination in persons who have suffered a stroke and explore whether the coupling between limbs can be exploited to promote fuctional recovery of an impaired limb. In particular, the research seeks to identify the critical components underlying the effectiveness of an intervention involving the pratice of actions bilaterally and simultaneously.Read moreRead less
An investigation of limb dynamics as a constraint on human motor learning. Everyday we use our limbs to interact with a variety of objects. These objects have various mechanical characteristics (dynamics), which require the human motor system to provide appropriate control. This project seeks to understand how the brain, in both normal and disease states, learns new limb dynamics as we interact with a novel mechanical environmental. Repetitive brain stimulation will be used to selectively block ....An investigation of limb dynamics as a constraint on human motor learning. Everyday we use our limbs to interact with a variety of objects. These objects have various mechanical characteristics (dynamics), which require the human motor system to provide appropriate control. This project seeks to understand how the brain, in both normal and disease states, learns new limb dynamics as we interact with a novel mechanical environmental. Repetitive brain stimulation will be used to selectively block the contribution of various cortical regions during the learning of a new motor skill and later, the recall of that skill. This will allow us to determine definitively which areas are critical to motor skill acquisition.Read moreRead less
Using eye movements to study how past experiences shape expectations. We intend to examine how the brain decides where to look next with our eyes, a decision made approximately three times every second. Understanding how the normal brain makes decisions will in turn help us to understand what happens when things go wrong in diseases like dementia and Parkinson's disease, with the hope of better - and earlier - diagnosis, and improved monitoring of treatment. In addition, our research will establ ....Using eye movements to study how past experiences shape expectations. We intend to examine how the brain decides where to look next with our eyes, a decision made approximately three times every second. Understanding how the normal brain makes decisions will in turn help us to understand what happens when things go wrong in diseases like dementia and Parkinson's disease, with the hope of better - and earlier - diagnosis, and improved monitoring of treatment. In addition, our research will establish an important research link with The University of Cambridge, and allow Australia to be competitive with laboratories in North America and Europe that are currently studying how the brain makes decisions about where to look.Read moreRead less
A computational and experimental investigation of reading aloud: Dyslexia, disyllables, and beyond. Australia is a world leader in computational cognitive science, particularly with respect to language processing. This project will help maintain and extend this position. Insights from the project will help us understand the processes that underlie both normal reading and reading disorders, particularly in areas that are comparatively neglected yet extremely important, such as how people read wor ....A computational and experimental investigation of reading aloud: Dyslexia, disyllables, and beyond. Australia is a world leader in computational cognitive science, particularly with respect to language processing. This project will help maintain and extend this position. Insights from the project will help us understand the processes that underlie both normal reading and reading disorders, particularly in areas that are comparatively neglected yet extremely important, such as how people read words of more than one syllable. Given that everyone in Australian needs to learn to read and that acquired and developmental disorders of reading are common, providing the theoretical base on which the processes involved in reading can be understood (and hence learnt and remediated most effectively) is of utmost importance.Read moreRead less
Investigation of the component distributions of pause duration in spontaneous speech: Constraints for models of language production. We have discovered that the distribution of pause durations in spontaneous speech of individual speakers can be decomposed into at least two log-normal distributions. Our project will investigate this finding and provide a foundation for new research relevant to language production models. This will be achieved by determining the semantic, lexical, psycholinguistic ....Investigation of the component distributions of pause duration in spontaneous speech: Constraints for models of language production. We have discovered that the distribution of pause durations in spontaneous speech of individual speakers can be decomposed into at least two log-normal distributions. Our project will investigate this finding and provide a foundation for new research relevant to language production models. This will be achieved by determining the semantic, lexical, psycholinguistic, physiological, and acoustic concomitants of each component distribution and by investigating the impact of selected variables on the shape and location of each. The project has important implications for models of language production and applied problems involving automatic speech recognition, forensic speaker identification, and human communication disorders.Read moreRead less