Incidence And Risk Factors For Cancer After Liver And Cardiothoracic Transplantation
Funder
National Health and Medical Research Council
Funding Amount
$301,220.00
Summary
We will examine the incidence of cancer in patients before and after heart, lung, and liver transplantation. We will also examine the risk factors for cancer in these populations, including viral infection, time since transplantation, and the cause of organ failure. We will do this by linking data held by world-class Australian transplantation registries and the national cancer registry. Comparisons with other immune-deficient populations will allow valuable insight into the causes of cancer.
Cancer Incidence In Recipients Of Haematopoietic Stem Cell Transplantation In Australia
Funder
National Health and Medical Research Council
Funding Amount
$408,788.00
Summary
Haematopoietic stem cell transplantation (HSCT) is widely used in Australia to treat patients with haematological cancers. The risk of developing second malignancies after HSCT has been increasingly recognised over recent decades as more and more patients survive. The proposed study will characterise the incidence and risk factors for cancer following HSCT. This information is essential for long-term surveillance and intervention strategies in both specialist and primary care settings.
Environmental And Genetic Factors In Childhood Acute Lymphoblastic Leukaemia: A Case-control Study.
Funder
National Health and Medical Research Council
Funding Amount
$1,788,500.00
Summary
In most countries, acute lymphoblastic leukaemia is the commonest cancer in children. One in 2000 children will develop this disease before their 15th birthday. New methods of treatment introduced over the last 30 years have resulted in cure for many children. However, one third of children diagnosed with this type of leukaemia still die and, even in those whose lives are saved, cure is achieved at a significant cost to the child, the family and the community. Greater understanding of the develo ....In most countries, acute lymphoblastic leukaemia is the commonest cancer in children. One in 2000 children will develop this disease before their 15th birthday. New methods of treatment introduced over the last 30 years have resulted in cure for many children. However, one third of children diagnosed with this type of leukaemia still die and, even in those whose lives are saved, cure is achieved at a significant cost to the child, the family and the community. Greater understanding of the development of childhood leukaemia may lead to preventive measures. Most children with this type of leukaemia are very young, suggesting that factors to which parents are exposed may affect future children. For this reason, as well as investigating the health and lifestyle of the child, it is essential to study the parents. Recent research suggests an association between the mother's intake of folate during pregnancy and her child's risk of developing the most common type of childhood leukaemia. It is also apparent that genetic differences result in varying abilities to deal with toxins, which may alter the risk of developing some cancers. Diet and lifestyle probably also affect this risk. These observations and interactions need to be examined in greater detail. In this large Australia-wide study specific genes will, for the first time, be examined and analysed in conjunction with rigorous assessment of exposures thought to be related to the development of childhood leukaemia. Results obtained from children with leukaemia and their parents will be compared with those from healthy children and their parents. This study is unique in its attempt to assess gene-environment interactions in Australian children and their parents. It will clarify the role of folate and other potential environmental agents in the development of childhood leukaemia and examine gene variations that may affect cancer risk.Read moreRead less
SES And Injury In Children: A Cohort Study To Identify And Measure The Effects Of Preventable Mediating Factors
Funder
National Health and Medical Research Council
Funding Amount
$360,505.00
Summary
While changing an individual or group SES is at best a long term and challenging social objective, proximal risk factors for injury can be more readily modified. Once the proximal risk factor differential across SES groups has been adequately delineated, then the possibility arises for targeted public health intervention to redress the SES differential in the incidence of injury. The sophistication of the proposed modeling will result in a good assessment of the best point to target.