The early osteoarthritis (OA) phenotype. Australia like many other developed countries is undergoing a major demographic shift involving significant growth in the aged population. From both a patient perspective and a societal perspective, research into the underlying determinants of osteoarthritis such as those outlined in this proposal are of great importance to the aged population. Nearly one in five Australians has arthritis; indeed more Australians have arthritis than any other national hea ....The early osteoarthritis (OA) phenotype. Australia like many other developed countries is undergoing a major demographic shift involving significant growth in the aged population. From both a patient perspective and a societal perspective, research into the underlying determinants of osteoarthritis such as those outlined in this proposal are of great importance to the aged population. Nearly one in five Australians has arthritis; indeed more Australians have arthritis than any other national health priority condition. From an individual point-of-view, the pain and disability due to osteoarthritis (OA) can lead to loss of independence and diminished in quality of life for older adults.Read moreRead less
Genetics of Postmenopausal Bone Loss. The major consequence of bone loss in our ageing society is fracture. At 50 years for women, the lifetime risk of sustaining an osteoporotic fracture is 50%. The consequences of these fractures, which can include reduced life expectancy, prolonged medical care, and loss of independence, have a profound socioeconomic impact in an ageing population. The proposed study offers a unique opportunity to examine the contribution of genetic factors to postmenopausal ....Genetics of Postmenopausal Bone Loss. The major consequence of bone loss in our ageing society is fracture. At 50 years for women, the lifetime risk of sustaining an osteoporotic fracture is 50%. The consequences of these fractures, which can include reduced life expectancy, prolonged medical care, and loss of independence, have a profound socioeconomic impact in an ageing population. The proposed study offers a unique opportunity to examine the contribution of genetic factors to postmenopausal osteoporosis.Read moreRead less
Lipidomics Associated with Metabolic Syndrome, Aging and Metabolic Variation between Species. The aim is to apply state-of?the-art mass spectrometry to identify and quantify alterations in membrane lipidomes (i.e. lipid classes, molecular species, structure alterations and by-products) related to two major health problems facing Australia i.e. the Metabolic Syndrome and an Ageing population plus insight into the variation in metabolic rate between organisms. This research offers the opportunity ....Lipidomics Associated with Metabolic Syndrome, Aging and Metabolic Variation between Species. The aim is to apply state-of?the-art mass spectrometry to identify and quantify alterations in membrane lipidomes (i.e. lipid classes, molecular species, structure alterations and by-products) related to two major health problems facing Australia i.e. the Metabolic Syndrome and an Ageing population plus insight into the variation in metabolic rate between organisms. This research offers the opportunity for the development of mass spectrometry based technologies for the early clinical diagnosis of metabolic disorders plus provides a template of information for our Linkage partner (AstraZeneca) to develop pharmaceutical therapies targeting key molecular lipid species identified as critical to particular membrane functions.Read moreRead less
Special Research Initiatives - Grant ID: SR0354797
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
The Australian Tissue Engineering Network. Driven by four key nodes across the country, the Initiative aims to bring together geographically and financially separated groups into a critical mass of cell and tissue engineering research. This new and rapidly-growing field uses a bio-synthetic approach to replace, repair or regenerate damaged tissues and organs. The Initiative will build the framework which will enable the Network to: identify appropriate expertise, manage duplication, enhance co ....The Australian Tissue Engineering Network. Driven by four key nodes across the country, the Initiative aims to bring together geographically and financially separated groups into a critical mass of cell and tissue engineering research. This new and rapidly-growing field uses a bio-synthetic approach to replace, repair or regenerate damaged tissues and organs. The Initiative will build the framework which will enable the Network to: identify appropriate expertise, manage duplication, enhance communication, bring together innovative skill sets, create linkages, generate focussed research programs and foster novel commercial opportunities. Ultimately the Initiative and Network will deliver an improved quality of life, reduced healthcare costs, and increased productivity to Australia.Read moreRead less
Growth of Bioartificial Tissue Containing an Inbuilt Blood Supply. The large and growing demand for replacement tissues and organs has spurred rapid growth in the emerging field of tissue engineering, which aims to form new tissues in the laboratory by combining living cells and synthetic scaffolds. A major challenge lies in the production of thick tissues, which require a blood supply in order to survive. Uniquely, this project aims to grow in the laboratory a vascular system based on natural ....Growth of Bioartificial Tissue Containing an Inbuilt Blood Supply. The large and growing demand for replacement tissues and organs has spurred rapid growth in the emerging field of tissue engineering, which aims to form new tissues in the laboratory by combining living cells and synthetic scaffolds. A major challenge lies in the production of thick tissues, which require a blood supply in order to survive. Uniquely, this project aims to grow in the laboratory a vascular system based on natural structures, which can then be used to support new tissue growth. Australia is well placed to reap the rewards of this work, having a track record in commercialisation of medical technologies, resulting in an improved quality of life for many Australians and substantial direct and indirect economic benefits.Read moreRead less
Improving the quality of nursing care and health outcomes for elderly patients during acute hospitalisation. This study aims to compare the perceptions of nurses, elderly patients and their carers in terms of the nursing needs of elderly hospitalised patients'. It will also investigate reasons for any differences found between expectations and reality of care provided. The significance is that the elderly are the largest consumers of health care yet this is the first collaborative Australian ....Improving the quality of nursing care and health outcomes for elderly patients during acute hospitalisation. This study aims to compare the perceptions of nurses, elderly patients and their carers in terms of the nursing needs of elderly hospitalised patients'. It will also investigate reasons for any differences found between expectations and reality of care provided. The significance is that the elderly are the largest consumers of health care yet this is the first collaborative Australian study to investigate the needs of elderly patients. Expected outcomes are an education program for nurses and the development of evidence-based models of nursing care for elderly patients, increased patient satisfaction and health outcomes. Hospitals ultimately benefit in cost-effectiveness and efficiency.Read moreRead less
Psychological determinants of physical activity across the life span and critical life-stage transitions: Cross-sectional, longitudinal causal modelling, and experimental interventions. Increasingly, sedentary lifestyles and physical inactivity are major worldwide health problems. Despite well-established health benefits of physical activity, existing medical-oriented interventions have had limited effects on increasing population-levels of activity. We propose a psychological approach, emphasiz ....Psychological determinants of physical activity across the life span and critical life-stage transitions: Cross-sectional, longitudinal causal modelling, and experimental interventions. Increasingly, sedentary lifestyles and physical inactivity are major worldwide health problems. Despite well-established health benefits of physical activity, existing medical-oriented interventions have had limited effects on increasing population-levels of activity. We propose a psychological approach, emphasizing quality of subjective experience (flow), motivation, physical self-concept, and the transtheoretical model of change. We will evaluate psychological determinants of health-related physical activity and implement experimental physical activity enhancing interventions at two critical life stages: for late-adolescents and older Australians. The proposal advances theory and methodology in a National Research Priority area, providing practical solutions to important societal problems with socioeconomic benefits for Australia.Read moreRead less
Effective management of challenging behaviours in cognitively impaired aged care residents through a research-based nursing care model. Challenging behaviours associated with cognitive impairment, such as screaming and perseveration, marks a decisive turning point in the life situation for an older person, heralding a deterioration in their quality of life and placement in an aged care facility. Staff can promote the residents health and well-being through person-centred care approaches. The stu ....Effective management of challenging behaviours in cognitively impaired aged care residents through a research-based nursing care model. Challenging behaviours associated with cognitive impairment, such as screaming and perseveration, marks a decisive turning point in the life situation for an older person, heralding a deterioration in their quality of life and placement in an aged care facility. Staff can promote the residents health and well-being through person-centred care approaches. The study employs Dementia Care Mapping to achieve these goals for the resident through participatory action research. The expected outcomes are a significant reduction in contextual factors that trigger these challenging behaviours, an improvement in the residents health, well-being and quality of life, and increased knowledge, skills and empowerment in staff.Read moreRead less