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I am a Clinical Immunologist, Immunopathologist, clinical researcher and laboratory scientist exploring the interactions between T cell and viral infections. My area of particular interest is the mechanisms by which HIV infection subverts effective T cel
A Randomised Open-label Study Comparing The Safety And Efficacy Of Two Alternative Treatment Options In The Management Of HIV-1 Infected Participants Who Have Virologically Failed A Standard First-line Combination ART Regimen
Funder
National Health and Medical Research Council
Funding Amount
$457,676.00
Summary
For the past decade there has been an unprecedented international effort to provide access to care for all HIV-infected people as a basic human right. Most of these people are treated with a simple combination of drugs that are well proven to control HIV. However, what to do when this first drug combination stops working is unknown. This study aims to fill that knowledge gap so that patients failing the first drug combination can be offered a second combination with a maximal chance of success.
Characterising Latent HIV Reservoirs: Examining The Effects Of Treatment Initiation, Cellular Type And Patient Genetics.
Funder
National Health and Medical Research Council
Funding Amount
$909,403.00
Summary
Conducted by a globally-renown team of HIV scientists and physicians, this clinically-relevant study makes a significant contribution to the emerging field of HIV eradication and cure. Accessing diverse and unique sample sets from HIV patients and applying innovative, ultra-sensitive genetic measurement techniques, the study definitively identifies the bodily reservoirs harbouring persistent HIV so they can be targeted by new therapies, a crucial step for efforts aimed at HIV eradication.
Recently Acquired Hepatitis C Infection: Insights From Virological, Therapeutic And Epidemiological Studies
Funder
National Health and Medical Research Council
Funding Amount
$415,218.00
Summary
Every year around 10,000 new cases of hepatitis C (HCV) infection occur within Australia, most of which are undiagnosed. Reasons for this include a lack of public awareness about the benefits of treatment at this stage. As new antiviral agents become available it is likely that therapy for recent HCV will become even easier and more successful. The aim of this research is to explore HCV transmission patterns, treatment strategies and long term health outcomes in people with recent HCV.
Thinking Outside The Box: Economic Evaluation Of Innovative Strategies To Expand HIV Testing In Men Who Have Sex With Men
Funder
National Health and Medical Research Council
Funding Amount
$490,096.00
Summary
Approximately 1 in 2 people living with HIV around the world have not been tested for HIV. Expanding HIV testing especially in key affected populations like men who have sex with men (MSM) would allow timely treatment and prevent transmission and disease progression. My project will build on my skills to conduct economic evaluations to determine the most cost-effective strategies to expand HIV testing in MSM.
Antiretroviral drugs reduce morbidity and mortality for people living with HIV however there is currently no cure for HIV. I will undertake a series of studies that will contribute to HIV cure research in Australia. This includes describing novel strategies to identify and measure residual dormant HIV in individuals on suppressive antiretroviral therapy, determining the effect of cancer drugs on dormant HIV, and exploring the attitudes of people living with HIV towards cure research.
Social Norms Regarding HIV-STI Risk And Risk Reduction Behaviours Among Men Who Have Sex With Men In Australia
Funder
National Health and Medical Research Council
Funding Amount
$692,269.00
Summary
In Australia, 85% of HIV infections are due to male homosexual contact. HIV-STI risk behaviour of individual gay-community-attached men has been well-studied, but social norms regarding behaviours are less well understood. We will collect new data about the norms regarding HIV-STI risk and risk reduction behaviours and compare their communication in gay communities in Sydney, Melbourne and Perth. This study will provide information to better target HIV prevention and promote safe sex among men.
An In Depth Analysis Of Clinical And Virological Outcomes Of 2 Strategies For The Antiretroviral Salvage Of First-line Regimen Virological Failure For HIV-1 Infection Tested In An Australian-led Randomised, International, Multi-centre Clinical Trial
Funder
National Health and Medical Research Council
Funding Amount
$421,747.00
Summary
The recently completed Australian-led SECOND-LINE trial is the first high quality study to provide reliable evidence for policy recommendations for the composition of anti-HIV drug cocktails after standard initial treatment has failed. This award will support the researcher in further refining our understanding of how to manage second-line therapy including proposals to test the use of low-cost technologies for application in resource-limited settings where the majority of people with HIV live.