A Randomised Controlled Trial Of A Couple-based Program For The Transition To Parenthood.
Funder
National Health and Medical Research Council
Funding Amount
$553,750.00
Summary
Couples who become parents face a very important and potentially very rewarding task: working together to raise their child. The current research evaluates the effects of a couple-based education program for people having their first child. The program helps couples develop realistic expectations about parenthood and effective ways of supporting each other as parents. The program also helps partners to understand and promote positive infant development, to enhance their couple communication, and ....Couples who become parents face a very important and potentially very rewarding task: working together to raise their child. The current research evaluates the effects of a couple-based education program for people having their first child. The program helps couples develop realistic expectations about parenthood and effective ways of supporting each other as parents. The program also helps partners to understand and promote positive infant development, to enhance their couple communication, and to promote a positive couple relationship while parenting. The program is offered through one face-to-face workshop held during the late stage of pregnancy, and then a home-based learning package consisting of a mix of videotaped information packages, reading and telephone based sessions with a psychologist. The overall aim is to produce an easily accessible support program for new parents that will enhance a couple's relationship with each other and their child. It is hoped this will reduce problems and enhance enjoyment of people becoming parents.Read moreRead less
Microglia As Primary Drivers Of Stress-induced Changes In Neuronal Connectivity
Funder
National Health and Medical Research Council
Funding Amount
$475,781.00
Summary
Persistent exposure to stressful events can produce serious and lasting disturbances in cognitive function. Our research group has recently identified that microglia may play a very significant role in these disturbances. The studies to be undertaken in this proposal will provide fundamental knowledge on how microglia contribute to neuronal plasticity, and how microglia via their effects on neurons regulate complex cognitive behaviour.
Using Astrocytes To Protect The Brain From Injury: Investigating Mechanisms And Therapeutic Strategies.
Funder
National Health and Medical Research Council
Funding Amount
$374,310.00
Summary
Brain damage caused by hypoxia (lack of oxygen) is a common problem in babies and can lead to outcomes ranging from cerebral palsy to death. We have a limited understanding of the mechanisms that cause damage, and thus very limited treatments. This project will investigate the role of cells called astrocytes in brain injury and identify novel therapeutic strategies to prevent or reverse brain damage. The outcomes of this research will ultimately lead to new treatments for hypoxic brain injury.
Microglial Paralysis In Post-stroke Neurodegeneration: Help Or Hindrance?
Funder
National Health and Medical Research Council
Funding Amount
$512,351.00
Summary
Dementia and cognitive decline may occur months or years after a stroke, associated with delayed loss of brain cells in different brain regions. We recently discovered that the cells responsible for protection and repair of brain, called microglia, become paralysed in these regions. We will use a live-imaging microscope to determine whether the microglial paralysis causes brain cell death. We will also determine if a commonly used stroke prevention drug can worsen the microglial paralysis.
Abnormalities in cells at the back of the eye called photoreceptors are associated with at least 50% of all cases of blindness in this country.This project will examine a novel mechanism of photoreceptor death. In particular, whether abnormalties in support cells at the back of the eye cause photoreceptors to lose contact with their nutrient source and die.
Neuron To Glia Signalling: Learning How Synaptic Signalling Can Promote CNS Remyelination
Funder
National Health and Medical Research Council
Funding Amount
$609,650.00
Summary
An immature cell type in the brain, known as the oligodendrocytes progenitor cell (OPC), receives direct electrical communication from neurons. This communication regulates the behavior of the OPC, affecting its ability to divide and generate new brain cells. This project will identify the signaling molecules that guide the OPC to for this specialized contact with the nerve cell. Understanding this communication has important implications for the treatment of Multiple Sclerosis.