Which Heart Failure Intervention Is Most Cost Effective In Reducing Hospital Care (WHICH? II) Trial: A Multicentre, Randomised Trial Of Standard Versus Intensified Management Of Metropolitan And Regional-dwelling Patients With Heart Failure
Funder
National Health and Medical Research Council
Funding Amount
$1,891,210.00
Summary
Chronic heart failure (CHF) management programs are now the gold-standard to cost-effectively care for thousands of Australians hospitalised with CHF each year. We’ve shown that home-based management is most cost-effective in reducing hospital stay in CHF. The Which Intervention is most Cost-effective in reducing Hospital care (WHICH? II) Trial, a multicentre, randomised study, will determine if more intensive care (via home visits and remote care contacts) further improves poor outcomes in CHF.
Determination Of Irradiation Dose Efficacy For Use In Impaction Grafting At Revision Joint Replacement
Funder
National Health and Medical Research Council
Funding Amount
$411,517.00
Summary
Primary hip replacement is a successful intervention for hip disease, but 10-15% of hip prostheses fail and require revision surgery within 10-15 years. At the time of revision, significant bone loss around the failed prosthesis is not uncommon. A bone reconstruction procedure, called impaction grafting, where donor bone is minced and placed in the areas of deficient bone before implanting the new prosthesis, has shown to give good results at more than ten years in some centres. A high incidence ....Primary hip replacement is a successful intervention for hip disease, but 10-15% of hip prostheses fail and require revision surgery within 10-15 years. At the time of revision, significant bone loss around the failed prosthesis is not uncommon. A bone reconstruction procedure, called impaction grafting, where donor bone is minced and placed in the areas of deficient bone before implanting the new prosthesis, has shown to give good results at more than ten years in some centres. A high incidence of early complications of this procedure have included loss of fixation within the bone. Fracture of the bone around prostheses has also reported in some centres. These events require more surgery, putting the patient at higher risk greater complications and longer rehabilitations. Recent improvements in surgical technique and donor bone preparation have improved results. A current debate questions whether the dose of irradiation can be reduced from 25 kGy, while maintaining sterility of allografts. The risk of bacterial contamination in allografts is low, and irradiation reduces the mechanical strength of the graft, contributing to complications when irradiated bone is used. The benefits of decontaminating the bone may be outweighed by the higher risk for failure due to poor bone quality and resulting prosthesis instability. We will use ISO standards to test the validity of radiation dose for sterilising bone ex vivo. In the absence of controlled human studies, our aim is also to compare the results of impaction grafting with non-irradiated bone versus bone irradiated at current doses used by Australian bone banks, and lower doses indicated by ex vivo testing. We will use a large animal model of revision hip replacement, with precise measures of prosthesis stability. The results of this study will guide clinical decisions regarding the efficacy of current bone graft preparation procedures and the use of irradiated bone in human hip replacement surgery.Read moreRead less
Special Research Initiatives - Grant ID: SR0354744
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Improving Australia's Data Mining and Knowledge Discovery Research. The network will bring together over 50 active researchers in data mining and knowledge discovery to enhance and better coordinate Australia's impressive research performance in these dual disciplines. Specifically, the network will (a) facilitate communication and collaboration between researchers, (b) fund or underwrite opportunities for international collaboration, (c) run a number of specialist workshops and symposia and (d ....Improving Australia's Data Mining and Knowledge Discovery Research. The network will bring together over 50 active researchers in data mining and knowledge discovery to enhance and better coordinate Australia's impressive research performance in these dual disciplines. Specifically, the network will (a) facilitate communication and collaboration between researchers, (b) fund or underwrite opportunities for international collaboration, (c) run a number of specialist workshops and symposia and (d) establish a national annual conference.Read moreRead less
The Risks And Benefits Of Contemporary Total Hip Replacement
Funder
National Health and Medical Research Council
Funding Amount
$493,530.00
Summary
The number of hip replacements undertaken in Australia is steadily increasing. The most common complications of hip replacements are dislocation and loosening due to bone loss around the implant, requiring complex and expensive revision surgery. This study will investigate the incidence of dislocation and, using a new diagnostic imaging technique, the incidence and amount of bone loss around a relatively new prosthetic material, the outcomes of which are not known despite its increasing use.
Tracing Past and Present Pollution Sources in the River Torrens, South Australia. The Torrens River is the principal water supply to 500,000 South Australians. Since early in European settlement it has suffered the impacts of eutrophication and high rates of sedimentation. The Catchment Management Board is seeking to prioritise rehabilitation resources to maximise water quality improvements. This will be informed by the revelation of the principal sources of sediment and nutrients over time.
Innovative Approach to the Optimal Management of Water Resources and Application to the Upper South East Region of South Australia. This project will increase Australia's capacity to manage water resources in an integrated and sustainable manner. The outcomes of this project will also provide significant economic, social and environmental benefits to the Upper South East region of South Australia, as well as the broader Australian community. The project is expected to result in a significant red ....Innovative Approach to the Optimal Management of Water Resources and Application to the Upper South East Region of South Australia. This project will increase Australia's capacity to manage water resources in an integrated and sustainable manner. The outcomes of this project will also provide significant economic, social and environmental benefits to the Upper South East region of South Australia, as well as the broader Australian community. The project is expected to result in a significant reduction in the economic and social costs associated with dryland salinity and flooding whilst simultaneously increasing the environmental benefits associated with the maintenance and rehabilitation of the ecological value of the some of the region's approximately 200 wetlands.Read moreRead less
Innovative approaches to managing and understanding taste and odour in drinking water systems. Taste and odour (T/O) problems resulting from Cyanobacteria can change consumers' perception of product safety, resulting in many complaints, soaring management and treatment costs, and large financial losses, yet little is known about how they arise.
This project will provide the Australian Water Industry with cost-effective, sensitive, specific, rapid and practical tools for managing and understandi ....Innovative approaches to managing and understanding taste and odour in drinking water systems. Taste and odour (T/O) problems resulting from Cyanobacteria can change consumers' perception of product safety, resulting in many complaints, soaring management and treatment costs, and large financial losses, yet little is known about how they arise.
This project will provide the Australian Water Industry with cost-effective, sensitive, specific, rapid and practical tools for managing and understanding T/O episodes, and will also benefit the aquaculture and food sectors, and the research community. An improved ability to manage geosmin in drinking water, will also have positive repercussions on the Australian environment, by eliminating the need to use environmentally controversial control methods such as copper sulphate dosing.
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Examining the effectiveness of co-creation practices on health outcomes. This projects aims to examine how patients interact collaboratively with multiple stakeholders in a health system (co-creation). Governments and health-care providers continually seek new ways to be more efficient and to create more effective health service outcomes. This research aims to identify why co-creation will be important in the formulation of future health policy. The project plans to assess patient-centred practi ....Examining the effectiveness of co-creation practices on health outcomes. This projects aims to examine how patients interact collaboratively with multiple stakeholders in a health system (co-creation). Governments and health-care providers continually seek new ways to be more efficient and to create more effective health service outcomes. This research aims to identify why co-creation will be important in the formulation of future health policy. The project plans to assess patient-centred practices using qualitative and quantitative health outcome measures and to model the patient’s end-to-end journey by developing new metrics. The intended outcomes are practical guidelines to help health professionals focus on the most effective co-creation activities and interactions. The research aims to determine how co-creation practices shape a service ecosystem by examining the effectiveness of a patient-centred approach on health care service outcomes. Findings will improve the implementation of health care practices.Read moreRead less
Technological innovation and change in supply chain integration. In examining emerging technology that can transform the performance of Australian industry we address the following priority goals: better understanding the processes that will advance knowledge and facilitate the development of technological innovations; the potential application of Radio Frequency Identification (RFID) technologies across an entire supply chain; and the improved management of information in the storage, distribut ....Technological innovation and change in supply chain integration. In examining emerging technology that can transform the performance of Australian industry we address the following priority goals: better understanding the processes that will advance knowledge and facilitate the development of technological innovations; the potential application of Radio Frequency Identification (RFID) technologies across an entire supply chain; and the improved management of information in the storage, distribution, and delivery of products (smart information use). Improvement in the operational efficiency and performance of the supply chain will increase national wealth while minimising environmental impacts on the environment, for example, through the better utilisation of heavy freight carriers.Read moreRead less
Strategic responses of Australian family-owned businesses in the manufacturing sector to the pressures of globalisation. It is critical that Australian family owned manufacturing businesses respond in the most advantageous way to the pressures of globalisation. Possible strategic responses include selling out to larger companies that have a stronger strategic position, competing off-shore, or take a niche position in the value chain. This research will use a series of case studies to determine t ....Strategic responses of Australian family-owned businesses in the manufacturing sector to the pressures of globalisation. It is critical that Australian family owned manufacturing businesses respond in the most advantageous way to the pressures of globalisation. Possible strategic responses include selling out to larger companies that have a stronger strategic position, competing off-shore, or take a niche position in the value chain. This research will use a series of case studies to determine the contingent factors that best explain strategic response within the ownership and management structure of the family business, and track the impact of specific strategic choices. From this may flow some general principles of appropriate strategic responses given a range of circumstances.Read moreRead less