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Bayesian statistical methods for enhancing evidence-based practice in Australia's hospitals. This project addresses Australia's national research priority of Promoting and Maintaining Good Health with the goal of Preventative Healthcare. Through enhanced capability in combining information from diverse sources for improved evidence-based decisions and true sharing of university and medical expertise, the project will enhance Australia's medical research and practice, align professional and comm ....Bayesian statistical methods for enhancing evidence-based practice in Australia's hospitals. This project addresses Australia's national research priority of Promoting and Maintaining Good Health with the goal of Preventative Healthcare. Through enhanced capability in combining information from diverse sources for improved evidence-based decisions and true sharing of university and medical expertise, the project will enhance Australia's medical research and practice, align professional and community expectations, utilise local medical information, and address national demands for quality science underpinning health decisions.
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Making the Most of Database Information in Patient-Based Decision-Making - A Bayesian Approach. This project addresses Australia's national research priority of Promoting and Maintaining Good Health and will lead to immediate improvement in health outcomes through optimising patient outcomes in Australian hospitals; cross-disciplinary and cross-hospital communication. Through enhanced capability in combining information from diverse sources the project will enhance Australia's medical research a ....Making the Most of Database Information in Patient-Based Decision-Making - A Bayesian Approach. This project addresses Australia's national research priority of Promoting and Maintaining Good Health and will lead to immediate improvement in health outcomes through optimising patient outcomes in Australian hospitals; cross-disciplinary and cross-hospital communication. Through enhanced capability in combining information from diverse sources the project will enhance Australia's medical research and practice, align professional and community expectations, utilise increased amounts of local medical information, and address national demands for quality science underpinning health decisions.Read moreRead less
Innovative Bayesian statistics for enhanced decision making for pharmaceutical drug development. This project addresses Australia's national research priority of Promoting and Maintaining Good Health, and will lead to improvements in health outcomes by patients accessing new drugs sooner, enhancing research, and reducing the cost of health care. Decision making in early stages of drug development will be improved by using novel statistical methods, which could also be applied in a variety of sit ....Innovative Bayesian statistics for enhanced decision making for pharmaceutical drug development. This project addresses Australia's national research priority of Promoting and Maintaining Good Health, and will lead to improvements in health outcomes by patients accessing new drugs sooner, enhancing research, and reducing the cost of health care. Decision making in early stages of drug development will be improved by using novel statistical methods, which could also be applied in a variety of situations involving decision making procedures. This will be achieved through cross-disciplinary and university-industry collaboration, utilising Australian and international expertise. National demands for quality science and trained researchers underpinning health decisions will be contributed to.Read moreRead less
Evaluating the feasibility and effect of using a hospital wide coordinated approach to introduce evidence-based changes for pain management. This project will develop a comprehensive educational program and approach to pain management for public and private hospitals that could be used by other hospitals elsewhere. An educational program for hospitals staff, and specifically for Pain Resource Nurses, will be produced. This project has the potential to minimise the experience of pain and prevent ....Evaluating the feasibility and effect of using a hospital wide coordinated approach to introduce evidence-based changes for pain management. This project will develop a comprehensive educational program and approach to pain management for public and private hospitals that could be used by other hospitals elsewhere. An educational program for hospitals staff, and specifically for Pain Resource Nurses, will be produced. This project has the potential to minimise the experience of pain and prevent widespread complications associated with pain for all hospitalised patients, irrespective of diagnosis or reason for admission. It is also envisaged that this project will establish a model of change that could be used to facilitate evidence-based practice in other aspects of healthcare apart from pain.Read moreRead less
Novel Drug Delivery Systems. The polymer based structures targeted for production in this project will bring unique capabilities to the field of drug delivery. A multi-drug delivery platform is expected to bring significant improvements in administering therapeutic drugs for a wide range of illnesses and applications. This will have profound effects on the quality of life for those suffering from epilepsy or requiring stent implants. Here we will demonstrate the capabilities of these novel polym ....Novel Drug Delivery Systems. The polymer based structures targeted for production in this project will bring unique capabilities to the field of drug delivery. A multi-drug delivery platform is expected to bring significant improvements in administering therapeutic drugs for a wide range of illnesses and applications. This will have profound effects on the quality of life for those suffering from epilepsy or requiring stent implants. Here we will demonstrate the capabilities of these novel polymer structures both in-vitro and in-vivo.Read moreRead less
The Ontogeny of Pain Behaviour: A Novel Neuroimmune Pathway. In Australia, 20% of the population report suffering from chronic pain. The cost of pain to Australian business per year is over $3 billion. Attempts to explain many chronic pain states, based on current knowledge, have failed. The central hypothesis of this project is that pain sensitivity is determined by programming of the fetal immune system during pregnancy. This research proposal will determine whether exposure to infection early ....The Ontogeny of Pain Behaviour: A Novel Neuroimmune Pathway. In Australia, 20% of the population report suffering from chronic pain. The cost of pain to Australian business per year is over $3 billion. Attempts to explain many chronic pain states, based on current knowledge, have failed. The central hypothesis of this project is that pain sensitivity is determined by programming of the fetal immune system during pregnancy. This research proposal will determine whether exposure to infection early in life determines sensitivity to pain in adult life. In doing so, this research offers a new theoretical explanation for the ontogeny of pain and may begin to account for the many forms of chronic pain that are currently not only unexplainable from current pain theory, but difficult to manage clinically.Read moreRead less
Advanced Materials for Stents. The polymer based materials targeted for production in this project will bring unique capabilities to the field of stent design. A multi-component degradable stent system is expected to bring significant improvements in vascular therapeutic treatments for a wide range of illnesses and applications. This will have significant advantages over current treatment and will have a positive impact on the quality of life of patients. The project brings together world leader ....Advanced Materials for Stents. The polymer based materials targeted for production in this project will bring unique capabilities to the field of stent design. A multi-component degradable stent system is expected to bring significant improvements in vascular therapeutic treatments for a wide range of illnesses and applications. This will have significant advantages over current treatment and will have a positive impact on the quality of life of patients. The project brings together world leaders in their respective fields to address a highly multidisciplinary are of research and will provide excellent training for the PhDs and post doctoral research associates, enabling them to work in and contribute to the development of new biomedical industries in Australia.Read moreRead less
Development and characterisation of novel hydrogel systems for drug delivery. The aims of this project are to develop and characterise hydrogel formulations for delivery of active agents, such as protein drugs, and to examine the biological responses to drug loaded hydrogels. In many medical and industrial fields, it is advantageous to control the release of active agents. Controlled release can decrease the dose of active that must be administered, sustain a more constant level of the agent ....Development and characterisation of novel hydrogel systems for drug delivery. The aims of this project are to develop and characterise hydrogel formulations for delivery of active agents, such as protein drugs, and to examine the biological responses to drug loaded hydrogels. In many medical and industrial fields, it is advantageous to control the release of active agents. Controlled release can decrease the dose of active that must be administered, sustain a more constant level of the agent in the environment and can localise the agent at the site where it is needed. This project will advance the theoretical knowledge of polymer degradation combined with protein release, will develop controlled release hydrogel technology that can be applied to medical devices and will train a postgraduate student in biomaterials and drug delivery.Read moreRead less
Design of an electronic guideline-driven decision support framework for home and community telehealth settings. With rapid advancements in the use of telecare-based health support in several emerging clinical areas, integrating these services within a stable guideline-driven decision support framework will support evidence-best practice in this setting, as well as improving efficiencies in clinical work practice and error minimisation through automation. The result could have a profound socio-ec ....Design of an electronic guideline-driven decision support framework for home and community telehealth settings. With rapid advancements in the use of telecare-based health support in several emerging clinical areas, integrating these services within a stable guideline-driven decision support framework will support evidence-best practice in this setting, as well as improving efficiencies in clinical work practice and error minimisation through automation. The result could have a profound socio-economic impact on the community and a sizable impact on healthcare outcomes; notwithstanding the substantial contribution it has to advancing the knowledge of medical decision support systems, supporting the national technology focus on health technology interoperability, and raising the profile of Australia as the foremost leader in the telecare area. Read moreRead less
Functionalised nanostructured polythiophenes: novel platforms for bionics. The nanostructured organic polymer materials targeted for production in this project will bring unique capabilities to the field of muscle regeneration. A multi-modal stimulation platform is expected to bring significant improvements in muscle cell growth. This will have profound effects on the quality of life for those suffering from neuromuscular disorders or other traumas that require muscle regeneration. This project ....Functionalised nanostructured polythiophenes: novel platforms for bionics. The nanostructured organic polymer materials targeted for production in this project will bring unique capabilities to the field of muscle regeneration. A multi-modal stimulation platform is expected to bring significant improvements in muscle cell growth. This will have profound effects on the quality of life for those suffering from neuromuscular disorders or other traumas that require muscle regeneration. This project will demonstrate the capabilities of these nanostructures in-vitro.Read moreRead less