Advancing Physiotherapy Management Of Chronic Pain By Improving Implementation Of Evidence-based Practice
Funder
National Health and Medical Research Council
Funding Amount
$115,883.00
Summary
Chronic musculoskeletal pain is major and concerning public health burden and physiotherapists provide a vital and influential role in managing this problem. High level research has demonstrated effective approaches to managing chronic pain yet there appears to be barriers to implementing such strategies clinically. This project aims to explore these barriers with physiotherapists, devise an intervention to overcome them, and test the feasibility and acceptability of the intervention.
Comparative Effectiveness Of Breast Tomosynthesis And Mammography In Real-world Population Screening: Evidence To Underpin And Improve Breast Cancer Screening
Funder
National Health and Medical Research Council
Funding Amount
$1,851,430.00
Summary
This research addresses key evidence gaps in breast cancer screening by investigating tomosynthesis (3D mammography) versus standard 2D mammography screening to establish the effectiveness of tomosynthesis in Australia and internationally, including impact on cancers not detected at screening that progress clinically. Large-scale studies will be done in real world screening services including a prospective comparative study planned collaboratively with BreastScreen to guide screening policy.
Optimizing Outpatient Parenteral Antibiotic Therapy To Support Hospital-in-the-home Program Across The Unique Environmental Conditions Of Australia
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
This project aims to solve problems associated with stability and dosing of antibiotic infusions given to patients in their homes, to support decision making by doctors and regulators. Currently, there is a lack of adequate data that complies with contemporary requirements. We will study infusion preparation both in laboratory settings and in ‘real-life’ conditions while being used by patients. We will enhance the stability of antibiotic preparations and optimize doses for effective treatment.
Broadening Choice and Increasing Diversity in Public Schools. Currently, most families are limited to the public school in their catchment area, meaning the area in which they can afford to live. This leads to socio-economically and ethnically homogenous schools and entrenches disadvantage, as well as denying students the crucial life lessons that flow from being part of a diverse student body. This project aims to investigate a model for allocating public school places that integrates catchment ....Broadening Choice and Increasing Diversity in Public Schools. Currently, most families are limited to the public school in their catchment area, meaning the area in which they can afford to live. This leads to socio-economically and ethnically homogenous schools and entrenches disadvantage, as well as denying students the crucial life lessons that flow from being part of a diverse student body. This project aims to investigate a model for allocating public school places that integrates catchment areas. The expected outcome would be a system that gives families a wider choice, enabling them to enrol in out-of-area schools, while ensuring that allocations remain fair, equitable and balanced, and also delivering benefits such as achieving a desired level of diversity in student populations within schoolsRead moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100168
Funder
Australian Research Council
Funding Amount
$413,847.00
Summary
Self-Supervised Sequential Biomedical Image-Omics. This project aims to develop a self-supervised sequential biomedical image-omics model to uncover the underlying biological processes e.g., normal or abnormal. Sequential biomedical images are state-of-the-art imaging modalities which allow to depict changes in progression to the human body. New self-supervised machine learning algorithms are proposed to derive features from heterogenous and unlabelled sequential images. These derived features w ....Self-Supervised Sequential Biomedical Image-Omics. This project aims to develop a self-supervised sequential biomedical image-omics model to uncover the underlying biological processes e.g., normal or abnormal. Sequential biomedical images are state-of-the-art imaging modalities which allow to depict changes in progression to the human body. New self-supervised machine learning algorithms are proposed to derive features from heterogenous and unlabelled sequential images. These derived features will then be used to characterise the morphological and functional changes, which provide opportunities to increase understanding of progression of diseases of individual subject. The outcome from this project will provide new insights into system biology with potential future benefits in healthcare.Read moreRead less
Extracting energy from air: mechanism of a bacterial hydrogenase. The atmosphere has recently been shown to be a key source of energy for diverse soil bacteria. Bacteria use complex enzymes, namely Huc-type hydrogenases, to harvest atmospheric hydrogen directly from air to support growth and survival. However, little is known about how Huc functions within and outside cells. By synergising expertise in microbiology, biochemistry, and chemistry, we will resolve the mechanism, assembly, and integr ....Extracting energy from air: mechanism of a bacterial hydrogenase. The atmosphere has recently been shown to be a key source of energy for diverse soil bacteria. Bacteria use complex enzymes, namely Huc-type hydrogenases, to harvest atmospheric hydrogen directly from air to support growth and survival. However, little is known about how Huc functions within and outside cells. By synergising expertise in microbiology, biochemistry, and chemistry, we will resolve the mechanism, assembly, and integration of Huc, including the basis of its remarkably high affinity and oxygen insensitivity compared to previously studied hydrogenases. This project will enable biotechnological applications, as the first study of an enzyme that extracts energy from air, and has broad ecological and biogeochemical implications.Read moreRead less
Testing strategy-proofness in matching markets: an experimental study. This project seeks to test and improve matching algorithms by investigating the effect of advice on strategy-proofness. Matching algorithms are used to solve allocation problems in designed markets (eg school or house allocation problems). Many of the algorithms employed are strategy-proof: participants never gain from strategising, that is, from lying about their preferences. Strategy-proofness had been seemingly validated b ....Testing strategy-proofness in matching markets: an experimental study. This project seeks to test and improve matching algorithms by investigating the effect of advice on strategy-proofness. Matching algorithms are used to solve allocation problems in designed markets (eg school or house allocation problems). Many of the algorithms employed are strategy-proof: participants never gain from strategising, that is, from lying about their preferences. Strategy-proofness had been seemingly validated by experimental research, but new evidence suggests that participants could be prone to follow wrong advice and therefore lie. In order to improve the performance of designed markets, the project proposes to further test strategy-proofness by investigating how advice can affect truth-telling in strategy-proof algorithms and whether learning can counteract or complement the effect of advice.Read moreRead less
The capacity for exceptional brain repair in a novel rodent species. This project aims to provide a new and much-needed living tool for studying brain injury and repair. The project expects to generate new evidence of effective brain repair in a mammalian species, the spiny mouse. In particular, it will provide important knowledge of the cellular responses that coordinate to allow mammalian brain repair, revealing targets for future understanding and treatment. Expected outcomes include an in-de ....The capacity for exceptional brain repair in a novel rodent species. This project aims to provide a new and much-needed living tool for studying brain injury and repair. The project expects to generate new evidence of effective brain repair in a mammalian species, the spiny mouse. In particular, it will provide important knowledge of the cellular responses that coordinate to allow mammalian brain repair, revealing targets for future understanding and treatment. Expected outcomes include an in-depth characterisation of how neurons and non-neuronal cells (glia) contribute to brain repair, and the identification of new pathways or targets for mammalian brain repair. In the long-term this should provide significant benefits for future research focused on improving the lives of people affected by brain injury. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100964
Funder
Australian Research Council
Funding Amount
$371,000.00
Summary
Understanding and designing persuasion mechanisms. The objective of this project is to understand and design persuasion mechanisms. Persuasion is about conveying information, influencing beliefs and manipulating actions. Educational campaigns and media censorship regulations are examples of persuasion mechanisms. Existing techniques from the economics of persuasion only permit analysis of specific and limited settings. This project aims to apply the classical mechanism design approach in a novel ....Understanding and designing persuasion mechanisms. The objective of this project is to understand and design persuasion mechanisms. Persuasion is about conveying information, influencing beliefs and manipulating actions. Educational campaigns and media censorship regulations are examples of persuasion mechanisms. Existing techniques from the economics of persuasion only permit analysis of specific and limited settings. This project aims to apply the classical mechanism design approach in a novel way to model persuasion in rich and realistic settings, thus providing insights into real-world situations. It is anticipated that this will allow us to answer questions such as ‘Should an educational campaign target different consumers with different information?’ and ‘When should a government censor extreme media outlets?'.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100260
Funder
Australian Research Council
Funding Amount
$457,378.00
Summary
Refugee moral injury: Linking interpersonal trauma and social functioning. This project aims to understand how moral beliefs about past interpersonal traumatic experiences (e.g., torture, rape) are associated with social outcomes considered to be crucial in successful refugee resettlement. This project will investigate the causal impact of these moral beliefs on social adaptation and whether these beliefs are malleable. The project will be a better understanding of how moral beliefs can impact r ....Refugee moral injury: Linking interpersonal trauma and social functioning. This project aims to understand how moral beliefs about past interpersonal traumatic experiences (e.g., torture, rape) are associated with social outcomes considered to be crucial in successful refugee resettlement. This project will investigate the causal impact of these moral beliefs on social adaptation and whether these beliefs are malleable. The project will be a better understanding of how moral beliefs can impact refugees' abilities to navigate and engage with novel social environments. The outcomes of this project will assist service providers and policy makers to understand why some refugees are able to adapt more successfully than others and provide practical tools for improving social outcomes. Read moreRead less