Engineering Hybrid Materials with Functional Bioactivity in the GI Tract. This project aims to use an advanced particle engineering approach to develop novel biomaterials with multifunctional activities in the gastrointestinal tract. The project expects to generate new fundamental knowledge of the key interfacial processes that control digestion and identify new pathways for modulating gut microbiome composition. By establishing structure-activity relationships through mechanistic in vitro and i ....Engineering Hybrid Materials with Functional Bioactivity in the GI Tract. This project aims to use an advanced particle engineering approach to develop novel biomaterials with multifunctional activities in the gastrointestinal tract. The project expects to generate new fundamental knowledge of the key interfacial processes that control digestion and identify new pathways for modulating gut microbiome composition. By establishing structure-activity relationships through mechanistic in vitro and in vivo models, the knowledge gain will help guide material design for optimised bioactivity. Technology transfer of the lead formulation through quality by design manufacturing practice is anticipated to position the industry partner for future commercial opportunities within the nutraceutical sector.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL220100185
Funder
Australian Research Council
Funding Amount
$3,269,608.00
Summary
Nanostructured Silicon-Based Wearable and Implantable Biosensors. The aim is to gain a deep understanding of the interface between nanostructured-silicon-based nanomaterials and biological systems, to develop a new generation of biosensor technologies applied on and in the body. Using innovative nanofabrication techniques, the team will integrate porous silicon nanomaterials with highly controllable optical and electrochemical properties into wearable and implantable biosensors for detecting bio ....Nanostructured Silicon-Based Wearable and Implantable Biosensors. The aim is to gain a deep understanding of the interface between nanostructured-silicon-based nanomaterials and biological systems, to develop a new generation of biosensor technologies applied on and in the body. Using innovative nanofabrication techniques, the team will integrate porous silicon nanomaterials with highly controllable optical and electrochemical properties into wearable and implantable biosensors for detecting bioanalytes directly and continuously in interstitial fluid, sweat, and blood; critically, they will be capable of long-term monitoring. The outcomes are expected to enable development of downstream applications across medical diagnostics, sports sciences, workplace testing as well as defence and space technologies.Read moreRead less
Resolving surface nanobubbles as cavitation nuclei. This project aims to investigate the onset and control of cavitation, a challenging problem for over half a century. Cavitation is a process of bubble growth and subsequent collapse, and causes noise and damage to adjacent surfaces, e.g. the failure of ship propellers and valves. This project expects to unravel the mystery of cavitation nuclei, and to develop cavitation-free designs to mitigate the cavitation caused damage to propellers and val ....Resolving surface nanobubbles as cavitation nuclei. This project aims to investigate the onset and control of cavitation, a challenging problem for over half a century. Cavitation is a process of bubble growth and subsequent collapse, and causes noise and damage to adjacent surfaces, e.g. the failure of ship propellers and valves. This project expects to unravel the mystery of cavitation nuclei, and to develop cavitation-free designs to mitigate the cavitation caused damage to propellers and valves, and noise. The anticipated outcomes will significantly advance existing fundamental knowledge at the forefront of fluid physics and provide Australia with a significant advantage in the marine, pump and valve industries, and significantly benefit the Australian industry and economy. Read moreRead less
A platform technology for developing mesoporous polymer particles. This project aims to apply polymerisation-induced self-assembly process to develop triggerable mesoporous polymer particles as advanced functional materials for various applications. By combining this scalable process and automated synthesis technique, mesoporous polymer particles that can disassemble in response to external triggers, such as light, redox conditions and enzymes, will be developed. The knowledge gained from this r ....A platform technology for developing mesoporous polymer particles. This project aims to apply polymerisation-induced self-assembly process to develop triggerable mesoporous polymer particles as advanced functional materials for various applications. By combining this scalable process and automated synthesis technique, mesoporous polymer particles that can disassemble in response to external triggers, such as light, redox conditions and enzymes, will be developed. The knowledge gained from this research will allow researchers to fully understand the formation and evolution mechanism of inverse bicontinuous structures observed in nature and produced in synthetic labs. Importantly, the applications of these novel stimuli-responsive particles as nano-carriers and templating scaffolds will be investigated.Read moreRead less