Research Training, Scientists, Mobility and Innovation: enhancing comparative methodologies. The collaboration will facilitate transfer of research value mapping (RVM) methods and technologies from a leading US centre into Australia. The RVM program focus on university-business collaboration will orient future collaborative projects and analyses. This will enhance the state-of-the-art of research evaluation in Australia over time. Extension of the CIs unique survey database will incorporate comp ....Research Training, Scientists, Mobility and Innovation: enhancing comparative methodologies. The collaboration will facilitate transfer of research value mapping (RVM) methods and technologies from a leading US centre into Australia. The RVM program focus on university-business collaboration will orient future collaborative projects and analyses. This will enhance the state-of-the-art of research evaluation in Australia over time. Extension of the CIs unique survey database will incorporate comparative dimensions into research value mapping. A focus on Australian respondents in the international database (n=1300) will lead to analyses that inform science policy and scientist human resource development in Australia. This will provide a deeper understanding of Australia’s science role in the Asia Pacific region.Read moreRead less
Trauma and Unwanted Memories. Post Traumatic Stress Disorder (PTSD) is a potentially debilitating condition that affects survivors of trauma. Intrusive memories of the trauma is the key problem in people with PTSD. This project will attempt to understand intrusive memories and will clarify why these memories persist. Outcomes from this project will directly assist people with PTSD because it will enhance understanding of a key symptom that maintains the disorder.
The role of households, neighbourhoods and networks in social statistics. Many issues affect the social progress of the country. Social research can determine the factors affecting issues such as unemployment, poverty, educational attainment, crime victimization and poor health. Survey and other data are used extensively to examine these conditions and their association with attributes of people. This project will provide methods to better determine the impact of effects associated with the h ....The role of households, neighbourhoods and networks in social statistics. Many issues affect the social progress of the country. Social research can determine the factors affecting issues such as unemployment, poverty, educational attainment, crime victimization and poor health. Survey and other data are used extensively to examine these conditions and their association with attributes of people. This project will provide methods to better determine the impact of effects associated with the household structure and other groups and social networks. The improved ability to assess the impact of these factors will have economic and social benefits. These benefits will arise from improved analysis leading to better decisions and improvements in the design of research studies improving their cost efficiency.Read moreRead less
Response style heterogeneity in empirical marketing research. This study aims to improve the validity of empirical studies by accounting for different ways in which respondents answer questionnaires (response styles) while analysing the data. Response styles have been shown to depend on the cultural background of respondents. This work therefore is of particular importance in Australia given the large number of cultural backgrounds residents come from. The proposed method will be empirically tes ....Response style heterogeneity in empirical marketing research. This study aims to improve the validity of empirical studies by accounting for different ways in which respondents answer questionnaires (response styles) while analysing the data. Response styles have been shown to depend on the cultural background of respondents. This work therefore is of particular importance in Australia given the large number of cultural backgrounds residents come from. The proposed method will be empirically tested in the context of surveys investigating sustainable tourism, public acceptance of alternative water sources and volunteering, three areas which are central to maintaining Australia's environmental sustainability and providing social and environmental services which are not covered by the commercial sector.Read moreRead less
Advanced issues in market segmentation research. We will investigate unresolved questions in market segmentation research that will provide answers to the following questions as outcome:
- How to pre-assess market segmentation data structure.
- How to improve the partitioning.
- How to visualize and present the resulting segmentation solutions.
- How to generalize the outcomes over multiple periods of time.
These tasks represent fundamental methodological research. The scientific significan ....Advanced issues in market segmentation research. We will investigate unresolved questions in market segmentation research that will provide answers to the following questions as outcome:
- How to pre-assess market segmentation data structure.
- How to improve the partitioning.
- How to visualize and present the resulting segmentation solutions.
- How to generalize the outcomes over multiple periods of time.
These tasks represent fundamental methodological research. The scientific significance consequently lies in knowledge development and methodological improvement. Findings will also enable both academic researchers using market segmentation methodology as well as practitioners applying such techniques to significantly improve the quality of their market structure analyses.Read moreRead less
Interfacial interactions with hydrogel biomaterials. The interactions between cells of the body and the surfaces of medical implants are controlled largely by the molecules that are adsorbed on the surface. The aim of this project is to evaluate the effect of modifying hydrogel biomaterials on the interactions of the molecules with the hydrogel. This, in turn, allows us to determine the factors affecting the control of the cell's response. The significance of this work is in the improved ability ....Interfacial interactions with hydrogel biomaterials. The interactions between cells of the body and the surfaces of medical implants are controlled largely by the molecules that are adsorbed on the surface. The aim of this project is to evaluate the effect of modifying hydrogel biomaterials on the interactions of the molecules with the hydrogel. This, in turn, allows us to determine the factors affecting the control of the cell's response. The significance of this work is in the improved ability to control cellular responses to implants. Such improved response will result in better health outcomes for patients, and outcomes in the form of papers and intellectual property.
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Male germ line transgenesis and siRNA technology for manipulating genes in domestic species. Professor Shemesh has successfully developed male germ line transgenesis in species such as bovine and chicken. This technology allows genes to be manipulated via sperm in a wide range of animals besides mice, avoiding the need for a female in vitro fertilization regimen. He is curently applying interference RNA (siRNA) transgenically to manipulate genes in vivo. Together these two technologies offer imm ....Male germ line transgenesis and siRNA technology for manipulating genes in domestic species. Professor Shemesh has successfully developed male germ line transgenesis in species such as bovine and chicken. This technology allows genes to be manipulated via sperm in a wide range of animals besides mice, avoiding the need for a female in vitro fertilization regimen. He is curently applying interference RNA (siRNA) transgenically to manipulate genes in vivo. Together these two technologies offer immense possibilities to manipulate a wide range of species for economic, biotechnological or medical research purposes. Professor Shemesh wishes to come to Adelaide to establish these technologies there as parts of ongoing research projects, related to the physiology of the ovarian hormone relaxin in aging research.Read moreRead less
Expand the capacity of an international multidisciplinary research network focussed on the ethical, legal and social implications of emerging biotechnologies. This project will ensure that Australia plays a central role in international debates and research activities aimed at regulating and facilitating advances in biotechnology. The project will also provide Australian researchers with direct access to key international experts in the field.
Combining the soft with the hard: The assembly of artificial cell membranes on porous semiconductors. The platform technologies developed in this project will have a wide range of applications. They will reveal new insights into drug-membrane and drug-protein interactions underpinning development of a new generation of drugs acting on transmembrane proteins that are linked to a wide range of diseases. The development of membrane-based biosensing devices targeting ion channels, membrane active pe ....Combining the soft with the hard: The assembly of artificial cell membranes on porous semiconductors. The platform technologies developed in this project will have a wide range of applications. They will reveal new insights into drug-membrane and drug-protein interactions underpinning development of a new generation of drugs acting on transmembrane proteins that are linked to a wide range of diseases. The development of membrane-based biosensing devices targeting ion channels, membrane active peptides or toxins which can be applied to biomedical diagnostics, biotoxin detection, environmental and food control will be readily achievable. This international interdisciplinary nanobiotechnology programme and its outcomes will enhance Australia's abilities in frontier technologies and build research strength in nanobiotechnology.Read moreRead less
Pharmacological and biochemical characterisation of Australian mygalomorph spider venoms. This project will increase our limited knowledge of Australian mygalomorph venoms by isolation, identification and characterisation of novel toxins in theraphosid and Northern mouse-spider venoms. Thereby, the scientific basis for the treatment of mygalomorph spider bites might be improved. Secondly, new insights into pharmacology and the potential development of novel therapeutics and molecular probes of t ....Pharmacological and biochemical characterisation of Australian mygalomorph spider venoms. This project will increase our limited knowledge of Australian mygalomorph venoms by isolation, identification and characterisation of novel toxins in theraphosid and Northern mouse-spider venoms. Thereby, the scientific basis for the treatment of mygalomorph spider bites might be improved. Secondly, new insights into pharmacology and the potential development of novel therapeutics and molecular probes of target molecules might be expected.Read moreRead less