An In Depth Analysis Of Clinical And Virological Outcomes Of 2 Strategies For The Antiretroviral Salvage Of First-line Regimen Virological Failure For HIV-1 Infection Tested In An Australian-led Randomised, International, Multi-centre Clinical Trial
Funder
National Health and Medical Research Council
Funding Amount
$421,747.00
Summary
The recently completed Australian-led SECOND-LINE trial is the first high quality study to provide reliable evidence for policy recommendations for the composition of anti-HIV drug cocktails after standard initial treatment has failed. This award will support the researcher in further refining our understanding of how to manage second-line therapy including proposals to test the use of low-cost technologies for application in resource-limited settings where the majority of people with HIV live.
Which Heart Failure Intervention Is Most Cost Effective In Reducing Hospital Care (WHICH? II) Trial: A Multicentre, Randomised Trial Of Standard Versus Intensified Management Of Metropolitan And Regional-dwelling Patients With Heart Failure
Funder
National Health and Medical Research Council
Funding Amount
$1,891,210.00
Summary
Chronic heart failure (CHF) management programs are now the gold-standard to cost-effectively care for thousands of Australians hospitalised with CHF each year. We’ve shown that home-based management is most cost-effective in reducing hospital stay in CHF. The Which Intervention is most Cost-effective in reducing Hospital care (WHICH? II) Trial, a multicentre, randomised study, will determine if more intensive care (via home visits and remote care contacts) further improves poor outcomes in CHF.
Analysing interactions within the criminal deportation system. This project aims to investigate the convergence of migration control and criminal justice by analysing pathways to criminal deportation. The project expects to generate new criminological understandings of deportation as a means of promoting community safety using interdisciplinary approaches that capture regional and metropolitan practice. Expected outcomes include knowledge of how information flows between migration control and cr ....Analysing interactions within the criminal deportation system. This project aims to investigate the convergence of migration control and criminal justice by analysing pathways to criminal deportation. The project expects to generate new criminological understandings of deportation as a means of promoting community safety using interdisciplinary approaches that capture regional and metropolitan practice. Expected outcomes include knowledge of how information flows between migration control and criminal justice agencies, and the implications for policing, courts, and prison administration. This should provide significant benefits for policy-makers and practitioners, by articulating emerging and unexplored practices that have major consequences for community safety, social cohesion and the rule-of-law.Read moreRead less
Probiotic Prawn Oral Immunotherapy (ProPIT) For Treatment Of Prawn Allergy
Funder
National Health and Medical Research Council
Funding Amount
$1,865,369.00
Summary
A ‘curative’ food allergy treatment is needed to prevent deaths and improve care. We recently showed that probiotic peanut oral immunotherapy (PPOIT) was highly effective for treating peanut allergy. 82% of PPOIT treated children gained tolerance compared to 4% of the placebo group. We will now test the combined probiotic-food OIT approach for treating prawn allergy. If successful, we will have identified the first treatment for prawn allergy and a platform treatment for other food allergies.
Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
Should Australia Introduce A National Chlamydia Testing Program? Evaluation Of A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$518,510.00
Summary
Chlamydia is a very common sexually transmissible infection that can lead to infertility in women. About 4% of young adults have it, yet most are unaware they have it. Chlamydia is easy to diagnose and treat, but it is not known whether annual testing can reduce its spread. Over1 million tests are conducted each year in general practice, costing the government $30 million. This evaluation of a well-established trial of chlamydia testing in young adults will resolve the debate of whether annual t ....Chlamydia is a very common sexually transmissible infection that can lead to infertility in women. About 4% of young adults have it, yet most are unaware they have it. Chlamydia is easy to diagnose and treat, but it is not known whether annual testing can reduce its spread. Over1 million tests are conducted each year in general practice, costing the government $30 million. This evaluation of a well-established trial of chlamydia testing in young adults will resolve the debate of whether annual testing works and is a good use of money.Read moreRead less
Designing for sustainability using a transformative repair model. The project will generate new knowledge in design-based repair and reuse of consumer products to develop a new community of craft and design practitioners, audience and clientele, in collaboration with leading Australian design and craft organisations. It responds to the pressing cultural and environmental burden of product obsolescence and consumer waste through innovation in transformative repair – a designed reworking of broken ....Designing for sustainability using a transformative repair model. The project will generate new knowledge in design-based repair and reuse of consumer products to develop a new community of craft and design practitioners, audience and clientele, in collaboration with leading Australian design and craft organisations. It responds to the pressing cultural and environmental burden of product obsolescence and consumer waste through innovation in transformative repair – a designed reworking of broken or discarded consumer objects that transforms their aesthetic appeal and cultural value. It applies transition design theory to develop localised progressions of the transformative repair model to foster knowledge exchange between partner organisation while contributing to a sustainable design economy in AustraliaRead moreRead less
The Ontogeny of Pain Behaviour: A Novel Neuroimmune Pathway. In Australia, 20% of the population report suffering from chronic pain. The cost of pain to Australian business per year is over $3 billion. Attempts to explain many chronic pain states, based on current knowledge, have failed. The central hypothesis of this project is that pain sensitivity is determined by programming of the fetal immune system during pregnancy. This research proposal will determine whether exposure to infection early ....The Ontogeny of Pain Behaviour: A Novel Neuroimmune Pathway. In Australia, 20% of the population report suffering from chronic pain. The cost of pain to Australian business per year is over $3 billion. Attempts to explain many chronic pain states, based on current knowledge, have failed. The central hypothesis of this project is that pain sensitivity is determined by programming of the fetal immune system during pregnancy. This research proposal will determine whether exposure to infection early in life determines sensitivity to pain in adult life. In doing so, this research offers a new theoretical explanation for the ontogeny of pain and may begin to account for the many forms of chronic pain that are currently not only unexplainable from current pain theory, but difficult to manage clinically.Read moreRead less
Special Research Initiatives - Grant ID: SR0354734
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
The Australian Research Network for Medical Devices: advanced technology solutions for patients and practitioners. Medical Device technologies embrace a wide range of scientific, engineering and medical knowledge, with the goal of assisting a clinical professional (doctor or nurse) deliver a service to a patient in an efficacious, cost effective manner. Development of appropriate medical devices, whether for diagnosis, treatment or prevention of disease or disability, is critical to improving h ....The Australian Research Network for Medical Devices: advanced technology solutions for patients and practitioners. Medical Device technologies embrace a wide range of scientific, engineering and medical knowledge, with the goal of assisting a clinical professional (doctor or nurse) deliver a service to a patient in an efficacious, cost effective manner. Development of appropriate medical devices, whether for diagnosis, treatment or prevention of disease or disability, is critical to improving health care and reducing health care costs. To be successful, a device must include all relevant disciplines in the research, development and testing phases. This network will bring together these groups, promoting knowledge sharing and cross-disciplinary investigations that illuminate current device limitations and potential solutions.Read moreRead less
Discovery Indigenous Researchers Development - Grant ID: DI0775809
Funder
Australian Research Council
Funding Amount
$28,000.00
Summary
Patterns of Engagement: The Contexts, Frequency and Characteristics of Psychological Practice with Indigenous Clients. The extent and debilitating nature of Indigenous mental health problems has been widely documented. National and community benefits will derive from the development of strategies enabling psychologists to work more effectively with Indigenous clients to improve their psychological and social well-being and resolve mental health problems. The project will identify how psychologis ....Patterns of Engagement: The Contexts, Frequency and Characteristics of Psychological Practice with Indigenous Clients. The extent and debilitating nature of Indigenous mental health problems has been widely documented. National and community benefits will derive from the development of strategies enabling psychologists to work more effectively with Indigenous clients to improve their psychological and social well-being and resolve mental health problems. The project will identify how psychologists currently work with Indigenous clients, which will provide data to guide the development of effective strategies to bring about change.Read moreRead less