Establishing advanced networks for air quality sensing and analyses. Establishing advanced networks for air quality sensing and analyses. This project aims to develop innovative, cost-effective, high resolution air quality networks. Recent developments in sensor technologies improve the ability to harvest atmospheric data. This project will develop, validate and implement methods for high sensitivity atmospheric sensing and apply cutting-edge statistical and analytic techniques to the data sets, ....Establishing advanced networks for air quality sensing and analyses. Establishing advanced networks for air quality sensing and analyses. This project aims to develop innovative, cost-effective, high resolution air quality networks. Recent developments in sensor technologies improve the ability to harvest atmospheric data. This project will develop, validate and implement methods for high sensitivity atmospheric sensing and apply cutting-edge statistical and analytic techniques to the data sets, unprecedented in scope and resolution. Outcomes include an open access database to quantify and visualise intra-urban air pollution and human exposure and develop air quality maps and smoke pollution management tools. It is expected to advance the evidence-based management of air as a resource, increasing economic prosperity and enhancing human health and quality of life.Read moreRead less
Which Heart Failure Intervention Is Most Cost Effective In Reducing Hospital Care (WHICH? II) Trial: A Multicentre, Randomised Trial Of Standard Versus Intensified Management Of Metropolitan And Regional-dwelling Patients With Heart Failure
Funder
National Health and Medical Research Council
Funding Amount
$1,891,210.00
Summary
Chronic heart failure (CHF) management programs are now the gold-standard to cost-effectively care for thousands of Australians hospitalised with CHF each year. We’ve shown that home-based management is most cost-effective in reducing hospital stay in CHF. The Which Intervention is most Cost-effective in reducing Hospital care (WHICH? II) Trial, a multicentre, randomised study, will determine if more intensive care (via home visits and remote care contacts) further improves poor outcomes in CHF.
Estimating per capita use and release of chemicals by wastewater analysis. This project aims to systematically collect and analyse wastewater to assess human exposure to chemicals including drugs, pharmaceuticals, lifestyle chemicals and environmental pollutants. By combining temporal sampling from key sewage treatment plants with comprehensive nationwide sampling over the week of the 2016 census day, the project expects to estimate the per-capita human exposure to chemicals in the Australian po ....Estimating per capita use and release of chemicals by wastewater analysis. This project aims to systematically collect and analyse wastewater to assess human exposure to chemicals including drugs, pharmaceuticals, lifestyle chemicals and environmental pollutants. By combining temporal sampling from key sewage treatment plants with comprehensive nationwide sampling over the week of the 2016 census day, the project expects to estimate the per-capita human exposure to chemicals in the Australian population. Accurate and objective per-capita based consumption and release estimates for a wide range of chemicals is intended to provide a baseline against which to measure changes in our chemosphere.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100155
Funder
Australian Research Council
Funding Amount
$648,000.00
Summary
NanoMin; Quantitative Mineral Mapping of Nanoscale Processes. NanoMin: quantitative mineral mapping of nanoscale processes:
The project seeks to establish an electron microscope-based mineral mapping and analysis facility to provide rapid, quantitative and statistically reliable mineralogical, petrographic and metallurgical data unobtainable by other means in fine-grained materials. The proposed equipment can identify minerals in complex mixtures of sub-µm-grain size materials by virtue of an i ....NanoMin; Quantitative Mineral Mapping of Nanoscale Processes. NanoMin: quantitative mineral mapping of nanoscale processes:
The project seeks to establish an electron microscope-based mineral mapping and analysis facility to provide rapid, quantitative and statistically reliable mineralogical, petrographic and metallurgical data unobtainable by other means in fine-grained materials. The proposed equipment can identify minerals in complex mixtures of sub-µm-grain size materials by virtue of an integrated software and hardware system called NanoMin which incorporates a spectral deconvolution engine combined with a mineral spectra database. A key limitation in understanding complex materials is sub-micron to nanometer scale spatial variability of mineralogical phases. Imaging and quantifying these phases is now possible with the NanoMin system. This promises to open up petrological, geobiological, and materials science research in complex fine-grained materials.Read moreRead less
Quantifying the flux of fugitive greenhouse gasses associated with coal seam gas and calibrating it to natural baseline and anthropogenic sources. Recent studies show that fugitive methane emissions associated with coal seam gas extraction pose a source of greenhouse gasses. In addition to the possible environmental impacts of methane emissions, quantifying the magnitude of emissions has potentially significant implications for future tax liabilities that could change the economics of the unconv ....Quantifying the flux of fugitive greenhouse gasses associated with coal seam gas and calibrating it to natural baseline and anthropogenic sources. Recent studies show that fugitive methane emissions associated with coal seam gas extraction pose a source of greenhouse gasses. In addition to the possible environmental impacts of methane emissions, quantifying the magnitude of emissions has potentially significant implications for future tax liabilities that could change the economics of the unconventional energy boom in Australia. The proposed research by an interdisciplinary team representing regulators, industry, and university researchers would establish a methodology for quantifying the flux of methane from gas fields. It would establish the range of natural baselines and determine the major sources of methane emissions using newly available highly sensitive instruments.Read moreRead less
Development Of Diagnostic Tools To Characterise Predictors Of Therapeutic Outcome In Severe Constipation
Funder
National Health and Medical Research Council
Funding Amount
$433,999.00
Summary
This project will use fibre-optic technology to create detailed high resolution maps of colonic motor patterns in both health and in patients with severe constipation. The data will be used in combination with actual patient symptoms to help identify specific markers of disease that can differentiate sub-types of constipation and ultimately guide and improve treatment in constipated patients
Clinical And Psychosocial Changes Over Late Childhood And Adolescence And Early Life Determinants Of Long Term Clinical Outcomes In Cystic Fibrosis
Funder
National Health and Medical Research Council
Funding Amount
$1,135,570.00
Summary
Cystic fibrosis is the most common life shortening inherited disease in Caucasians. Lung damage starts in infancy and lung function falls most rapidly in adolescence although why and how this happens and early life determinants are not known. This study takes advantage of a previous study that monitored young children from 3 months to 5 years of life and follows them closely through early adolescence to investigate the protective and risk factors for falling lung function.
Probiotic Prawn Oral Immunotherapy (ProPIT) For Treatment Of Prawn Allergy
Funder
National Health and Medical Research Council
Funding Amount
$1,865,369.00
Summary
A ‘curative’ food allergy treatment is needed to prevent deaths and improve care. We recently showed that probiotic peanut oral immunotherapy (PPOIT) was highly effective for treating peanut allergy. 82% of PPOIT treated children gained tolerance compared to 4% of the placebo group. We will now test the combined probiotic-food OIT approach for treating prawn allergy. If successful, we will have identified the first treatment for prawn allergy and a platform treatment for other food allergies.
An In Depth Analysis Of Clinical And Virological Outcomes Of 2 Strategies For The Antiretroviral Salvage Of First-line Regimen Virological Failure For HIV-1 Infection Tested In An Australian-led Randomised, International, Multi-centre Clinical Trial
Funder
National Health and Medical Research Council
Funding Amount
$421,747.00
Summary
The recently completed Australian-led SECOND-LINE trial is the first high quality study to provide reliable evidence for policy recommendations for the composition of anti-HIV drug cocktails after standard initial treatment has failed. This award will support the researcher in further refining our understanding of how to manage second-line therapy including proposals to test the use of low-cost technologies for application in resource-limited settings where the majority of people with HIV live.