An International Clinical Trial To Evaluate New Therapies To Improve Survival Of Children With Relapsed Acute Lymphoblastic Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$1,567,500.00
Summary
Children who relapse with childhood leukaemia have only a 50% chance of being alive after 5 years. We will participate in a new international trial involving most European and all Australian and New Zealand childhood oncology centres, to test the effectiveness of promising new treatments and to perform biological studies which should enable doctors in future to pick the best treatment for each of these patients.
Fate of micropollutants in water recycling: influence of dissolved organic matter. Access to safe drinking water is essential for the economic and social development of Australia. There is increasing interest in applying advanced water treatment processes, such as membrane filtration or ozonation, to treat secondary effluent to a potable standard. This project promotes improved organic pollutant removal and monitoring during advanced water treatment and will contribute to the National Research P ....Fate of micropollutants in water recycling: influence of dissolved organic matter. Access to safe drinking water is essential for the economic and social development of Australia. There is increasing interest in applying advanced water treatment processes, such as membrane filtration or ozonation, to treat secondary effluent to a potable standard. This project promotes improved organic pollutant removal and monitoring during advanced water treatment and will contribute to the National Research Priority goal, water - a critical resource, by providing the increased protection of receiving waters including rivers and seawater. Further, as very few studies consider the role of dissolved organic matter for organic pollutant fate in water reuse internationally, this project will help to advance Australia's position in science.Read moreRead less
Advancing vegetation classification and mapping to meet conservation needs. The project aims to develop advanced statistical and modelling techniques to classify and map vegetation over very large areas, using the most extensive and detailed vegetation data set in Australia and new methods to evaluate these classifications. Such classifications and maps provide the data needed to make biodiversity conservation decisions, yet current operational methods are limited over very large areas, and cann ....Advancing vegetation classification and mapping to meet conservation needs. The project aims to develop advanced statistical and modelling techniques to classify and map vegetation over very large areas, using the most extensive and detailed vegetation data set in Australia and new methods to evaluate these classifications. Such classifications and maps provide the data needed to make biodiversity conservation decisions, yet current operational methods are limited over very large areas, and cannot deal with varied sources of uncertainty. Expected outcomes and benefits include a fine-scale vegetation classification and map for almost a million square kilometres, and associated analytical tools and guidelines for large-scale vegetation classification and global mapping.Read moreRead less
Australian Resuscitation Outcomes Consortium [AUS-ROC] CRE
Funder
National Health and Medical Research Council
Funding Amount
$2,668,571.00
Summary
The Australian Resuscitation Outcomes Consortium (Aus-ROC) will be modelled on the highly successful North American Resuscitation Outcomes Consortium. The mission of Aus-ROC will be to conduct clinical trials and observational studies into the emergency management of out-of-hospital cardiopulmonary arrest. Building on our existing collaborative partnerships, our goal is to improve patient outcomes and build the research capacity in prehospital emergency care.
There is increased recognition that sleep health problems are a major cause of illness in the community. These include disorders such as obstructive sleep apnoea, insomnia, restless legs syndrome and health problems related to shift work. It is proposed to form a consolidated network of sleep investigation groups to undertake larger scale clinical trials aimed at deciding what are the best treatments for different sleep disorders. The enabling grant will provide resources that will make Australi ....There is increased recognition that sleep health problems are a major cause of illness in the community. These include disorders such as obstructive sleep apnoea, insomnia, restless legs syndrome and health problems related to shift work. It is proposed to form a consolidated network of sleep investigation groups to undertake larger scale clinical trials aimed at deciding what are the best treatments for different sleep disorders. The enabling grant will provide resources that will make Australian involvement in international studies more competitive and achieve higher publication quality for the research work.Read moreRead less
Clinical Impact Of Clonal Pseudomonas Aeruginosa In Cystic Fibrosis
Funder
National Health and Medical Research Council
Funding Amount
$547,238.00
Summary
In patients with cystic fibrosis (CF), the normal defence mechanisms are compromised by an inherent genetic fault which results in an extremely sticky and dehydrated mucus. The respiratory system is unable to eradicate microbes (infection) from the lungs of patients with CF which begin to multiply and cause infection and inflammation. Recurring infections are treated with multiple courses of antibiotics and frequent hospitalisation and eventually result in premature death. This study focuses on ....In patients with cystic fibrosis (CF), the normal defence mechanisms are compromised by an inherent genetic fault which results in an extremely sticky and dehydrated mucus. The respiratory system is unable to eradicate microbes (infection) from the lungs of patients with CF which begin to multiply and cause infection and inflammation. Recurring infections are treated with multiple courses of antibiotics and frequent hospitalisation and eventually result in premature death. This study focuses on the major bacterial problem, Pseudomonas aeruginosa. Several studies from Australia and the UK, including our own have shown that about 30% to 45% of patients share the same strain of Pseudomonas aeruginosa within a centre. We know that two dominant strains of Pseudomonas aeruginosa are found in CF centres on the eastern board of Australia. This is unexpected as this bacterium is usually acquired from the environment. The emergence of these clonal strains is causing increasing anxiety in the CF community. This study is designed to provide vitally needed information on the clinical implications of being infected by an clonal strain of Pseudomonas aeruginosa and the risk factors for the acquisition of an clonal strain. This new information will provide a rationale basis for the need for changes to infection control policies (including patient segregation), better outcome predictors for patients infected with clonal strain of Pseudomonas aeruginosa.Read moreRead less
Reducing Deaths From Pesticide Poisoning - Establishing A Regional Toxicology Research Centre.
Funder
National Health and Medical Research Council
Funding Amount
$739,727.00
Summary
The World Health Organization estimates suggest nearly half a million people die from acute pesticide poisoning in the Asia-Pacific region each year. The Sri Lankan project will be the first attempt to systematically test whether a range of strategies can reduce long-term neurological damage and deaths from pesticides. The Australian-Sri Lankan Collaboration will, over the next five years, aim to improve assessment of sub-acute and long-term morbidity; promote 'evidence-based' treatment; develop ....The World Health Organization estimates suggest nearly half a million people die from acute pesticide poisoning in the Asia-Pacific region each year. The Sri Lankan project will be the first attempt to systematically test whether a range of strategies can reduce long-term neurological damage and deaths from pesticides. The Australian-Sri Lankan Collaboration will, over the next five years, aim to improve assessment of sub-acute and long-term morbidity; promote 'evidence-based' treatment; develop new antidotes (and assess their cost effectiveness), and see if pesticide regulation can reduce the rate of severe or fatal poisoning. If successful, this program may become a model for the region as to how to substantially reduce this largely hidden tragedy.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100260
Funder
Australian Research Council
Funding Amount
$457,378.00
Summary
Refugee moral injury: Linking interpersonal trauma and social functioning. This project aims to understand how moral beliefs about past interpersonal traumatic experiences (e.g., torture, rape) are associated with social outcomes considered to be crucial in successful refugee resettlement. This project will investigate the causal impact of these moral beliefs on social adaptation and whether these beliefs are malleable. The project will be a better understanding of how moral beliefs can impact r ....Refugee moral injury: Linking interpersonal trauma and social functioning. This project aims to understand how moral beliefs about past interpersonal traumatic experiences (e.g., torture, rape) are associated with social outcomes considered to be crucial in successful refugee resettlement. This project will investigate the causal impact of these moral beliefs on social adaptation and whether these beliefs are malleable. The project will be a better understanding of how moral beliefs can impact refugees' abilities to navigate and engage with novel social environments. The outcomes of this project will assist service providers and policy makers to understand why some refugees are able to adapt more successfully than others and provide practical tools for improving social outcomes. Read moreRead less
The Centre for Research Excellence in Nursing Interventions for Hospitalised Patients will provide evidence to improve the nursing care of a broad range of hospitalised patients who are at risk of complications related to compromised skin integrity and poor pain/anxiety management. Systematic reviews and clinical trials will provide the basis for developing clinical practice guidelines to assist nurses in providing high quality care to the 3.5 million Australians admitted to hospital each year.
Investigating Linguistic Factors Associated with Stuttering in Cantonese. The aim of this research is to gain new knowledge about the cause of stuttering. The project is a collaboration between experts in stuttering in Australia and Hong Kong. Despite decades of study, the cause of stuttering is still not well understood. Research in English has suggested that changes in emphasis from syllable to syllable can trigger individual moments of stuttering. However, Cantonese is very different from Eng ....Investigating Linguistic Factors Associated with Stuttering in Cantonese. The aim of this research is to gain new knowledge about the cause of stuttering. The project is a collaboration between experts in stuttering in Australia and Hong Kong. Despite decades of study, the cause of stuttering is still not well understood. Research in English has suggested that changes in emphasis from syllable to syllable can trigger individual moments of stuttering. However, Cantonese is very different from English, being a tonal and syllabic language, and uncovering the linguistic triggers of stuttering in Cantonese will yield new insight into the complex causality of this disabling condition.Read moreRead less