Defining the molecular and cellular mechanisms of beta cell dysfunction. This project will investigate the influence of environment in the functional adaptation and maladaptation of pancreatic beta cells in diabetes. The research will define the molecular and cellular mechanisms linking environmental triggers such as obesity, high fatty acid levels and hyperglycaemia to beta cell dedifferentiation and dysfunction.
Using mathematical modelling to inform HIV/AIDS public health policy. This research will directly inform HIV/AIDS policy officials on the most effective strategies for preventing new cases in HIV in the community. Consequently, there are health benefits for Australia and for the other countries in which the research is being conducted. HIV/AIDS community groups, educators, and other advocacy groups will also be engaged in the research, leading to the development of focussed prevention campaigns ....Using mathematical modelling to inform HIV/AIDS public health policy. This research will directly inform HIV/AIDS policy officials on the most effective strategies for preventing new cases in HIV in the community. Consequently, there are health benefits for Australia and for the other countries in which the research is being conducted. HIV/AIDS community groups, educators, and other advocacy groups will also be engaged in the research, leading to the development of focussed prevention campaigns by these stakeholders to inform the appropriate communities. Reducing the health burdens of HIV/AIDS will also have economic benefits.Read moreRead less
Generating evidence for nature-based strategies to reduce loneliness. While loneliness and despair are reportedly increasing due to social and economic upheaval caused by the COVID-19 pandemic, governments are investing in urban greening. This project aims to help steer greening strategies to reduce loneliness and despair, to enable recoveries from COVID-19 that are more sustainable, equitable and nourishing. This project will: (1) engage with leading scientists within and outside Australia to f ....Generating evidence for nature-based strategies to reduce loneliness. While loneliness and despair are reportedly increasing due to social and economic upheaval caused by the COVID-19 pandemic, governments are investing in urban greening. This project aims to help steer greening strategies to reduce loneliness and despair, to enable recoveries from COVID-19 that are more sustainable, equitable and nourishing. This project will: (1) engage with leading scientists within and outside Australia to formalise my draft conceptual model of pathways linking urban greening with loneliness and despair; (2) test associations and pathways with multiple sources of nationally representative data; (3) supervise a mixed-methods PhD project; and (4) share findings for building up knowledge capacities and guideline development.Read moreRead less
Interpreting intrusions: Illuminating the cognitive mechanisms that fuel obsessional thought. This project aims to evaluate a theoretical model regarding the causal and maintaining role that cognitive biases play in obsessional thought. Obsessions are common in the general population and negatively impact health and daily functioning. Individuals struggle with their obsessions but are unable to disengage from them. A pressing question is: what makes an obsession so “sticky”? To answer this quest ....Interpreting intrusions: Illuminating the cognitive mechanisms that fuel obsessional thought. This project aims to evaluate a theoretical model regarding the causal and maintaining role that cognitive biases play in obsessional thought. Obsessions are common in the general population and negatively impact health and daily functioning. Individuals struggle with their obsessions but are unable to disengage from them. A pressing question is: what makes an obsession so “sticky”? To answer this question, this project aims to employ a novel, computerised experimental methodology to directly manipulate cognitive processes proposed to underpin obsessions. This methodology will be used to alter key biases proposed to drive obsessional thinking, thus shedding light on core psychological mechanisms.Read moreRead less
Mental health, job quality and workforce participation: evidence from population health research to address complex problems and conflicting policies. Mental disorders such as depression are a major cause of disability. Improving mental health can increase productivity and workforce participation. However, the psychosocial quality of work is a factor that overlays the relationship between work and health. Poor quality work (for example, unreasonable time pressure, insecurity) increases the risk ....Mental health, job quality and workforce participation: evidence from population health research to address complex problems and conflicting policies. Mental disorders such as depression are a major cause of disability. Improving mental health can increase productivity and workforce participation. However, the psychosocial quality of work is a factor that overlays the relationship between work and health. Poor quality work (for example, unreasonable time pressure, insecurity) increases the risk of poor mental health, absenteeism, and exit from the workforce. This project will analyse data following people over time to investigate the long-term health and employment consequences of poor psychosocial job quality, and consider the special case of mature age workers. It will identify those individuals at greatest risk, and factors that can buffer against the adverse effects of poor quality work.Read moreRead less
Better prevention and management of disabling back pain. This project will establish a program of back pain research within an inter-disciplinary research centre focused on the prevention and management of physical disability.
Towards a healthier food supply: achieving policy change and industry action. This research aims to identify mechanisms by which to improve the quality of the Australian food supply. The findings will have the potential to inform government and industry policies on healthier foods with the aim of decreasing chronic disease.
Reducing the social, economic and health burden associated with obesity-related chronic diseases among socio-economically disadvantaged populations. This project will develop new methods and approaches for reducing obesity-related chronic diseases (OCDs) among socially disadvantaged populations in Australia, using prevention models. These prevention models will improve the evidence base in this field as well as inform public health policy and practice in Australia (and other industrialised count ....Reducing the social, economic and health burden associated with obesity-related chronic diseases among socio-economically disadvantaged populations. This project will develop new methods and approaches for reducing obesity-related chronic diseases (OCDs) among socially disadvantaged populations in Australia, using prevention models. These prevention models will improve the evidence base in this field as well as inform public health policy and practice in Australia (and other industrialised countries).Read moreRead less
Understanding genetic and environmental risks of emotional disorders in childhood and adolescence. To reduce the burden of mental health disorders in Australia, this project will advance knowledge on genetic and environmental causes of anxiety and related disorders in children and adolescents. The results will allow better identification of children at risk for emotional problems and will identify new ways of tailoring prevention and treatment.
The early osteoarthritis (OA) phenotype. Australia like many other developed countries is undergoing a major demographic shift involving significant growth in the aged population. From both a patient perspective and a societal perspective, research into the underlying determinants of osteoarthritis such as those outlined in this proposal are of great importance to the aged population. Nearly one in five Australians has arthritis; indeed more Australians have arthritis than any other national hea ....The early osteoarthritis (OA) phenotype. Australia like many other developed countries is undergoing a major demographic shift involving significant growth in the aged population. From both a patient perspective and a societal perspective, research into the underlying determinants of osteoarthritis such as those outlined in this proposal are of great importance to the aged population. Nearly one in five Australians has arthritis; indeed more Australians have arthritis than any other national health priority condition. From an individual point-of-view, the pain and disability due to osteoarthritis (OA) can lead to loss of independence and diminished in quality of life for older adults.Read moreRead less