Tissue Bio-physicochemical Quantification Using Magnetic Resonance Imaging. This project aims to develop novel magnetic resonance imaging methods to investigate tissue structure and function. Current MRI technologies use standard water-based contrast mechanisms to generate images with limited tissue information. In contrast, this project expects to provide a non-invasive, ultra-high-resolution MRI technology that measures the electrical, magnetic, and chemical signals generated from the human bo ....Tissue Bio-physicochemical Quantification Using Magnetic Resonance Imaging. This project aims to develop novel magnetic resonance imaging methods to investigate tissue structure and function. Current MRI technologies use standard water-based contrast mechanisms to generate images with limited tissue information. In contrast, this project expects to provide a non-invasive, ultra-high-resolution MRI technology that measures the electrical, magnetic, and chemical signals generated from the human body. Thus, the new imaging methods can probe deeper biological functionality while examining tissue structure. The potential benefits include: expanding the scope and capabilities of current MRI, facilitating a wide range of imaging-based research and applications, and accelerating knowledge expansion in life science.Read moreRead less
A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological respon ....A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological response from the nasal mucosa. The aim is to overcome a key fabrication challenge - to 3D print an anatomically accurate nasal construct with a porous wall on which to grow and mature functional nasal tissue that lines a nasal cavity wall. The benefit would be enabling faster development of more targeted drugs and vaccines.Read moreRead less
Development of Control Methodologies for Drug Dosing in Biomedical Engineering. This research proposal is very relevant to the National Research Priorities in the areas of Frontier Technologies and Breakthrough science. At a broader level, we aim to assist in the development of a national competence in what has been an emerging and promising discipline. The research will develop fundamental and enabling laws and techniques for drug administration to regulate physiological variables such as blood ....Development of Control Methodologies for Drug Dosing in Biomedical Engineering. This research proposal is very relevant to the National Research Priorities in the areas of Frontier Technologies and Breakthrough science. At a broader level, we aim to assist in the development of a national competence in what has been an emerging and promising discipline. The research will develop fundamental and enabling laws and techniques for drug administration to regulate physiological variables such as blood pressure and degree of consciousness in critical care patients.Read moreRead less
Robotic gait assistive strategy for people with paraplegia: Generating balanced and human-like gait on a bipedal system. The outcomes of the project will contribute significantly to the fundamental understanding of bipedal mechanisms, robotics, and the dynamics of human gait. This research is unique in Australia and it will strengthen Australia's research standing in robotics and health-sciences. The immediate application of the outcomes will contribute significantly to the musculoskeletal and p ....Robotic gait assistive strategy for people with paraplegia: Generating balanced and human-like gait on a bipedal system. The outcomes of the project will contribute significantly to the fundamental understanding of bipedal mechanisms, robotics, and the dynamics of human gait. This research is unique in Australia and it will strengthen Australia's research standing in robotics and health-sciences. The immediate application of the outcomes will contribute significantly to the musculoskeletal and psychological health of people with spinal cord injury, as well as the basic locomotion capability around the house to carry out their daily tasks more independently and conveniently. Hence it will directly contribute to improving their quality of life and substantially reducing health-care costs and carer responsibilities in the community.Read moreRead less
Ultrathin Gold Nanocrystal Conductors for Wearable Epidermal Biofuel Cells. This project aims to fabricate ultrathin, soft yet stretchable gold nanocrystal conductors to push the thickness limit of next-generation soft bioelectrodes for fabrication of wearable epidermal biofuel cells. This will generate new knowledge and patentable technologies related to design/fabrication of soft nanocrystal conductors, bioanode and biocathode, which require to be thin, soft, conductive and biocompatible. Expe ....Ultrathin Gold Nanocrystal Conductors for Wearable Epidermal Biofuel Cells. This project aims to fabricate ultrathin, soft yet stretchable gold nanocrystal conductors to push the thickness limit of next-generation soft bioelectrodes for fabrication of wearable epidermal biofuel cells. This will generate new knowledge and patentable technologies related to design/fabrication of soft nanocrystal conductors, bioanode and biocathode, which require to be thin, soft, conductive and biocompatible. Expected outcomes of this project include enhanced national capacity in disruptive wearable bioelectronics, strengthening international collaborations, unskilled workforce training, as well as advancement of Australian knowledge base in the fields of nanotechnology, materials science, energy, biosensors and bioelectronics.Read moreRead less
Final frontier in computational modelling of movement. This project aims to create the computational models and methods needed to advance current understanding of musculoskeletal function during movement. Humans must maintain their capacity to move in order to maintain quality-of-life. Predictive modelling is potentially the most powerful approach for understanding musculoskeletal function during movement. Current computational methods are too slow and unreliable to deliver predictive simulation ....Final frontier in computational modelling of movement. This project aims to create the computational models and methods needed to advance current understanding of musculoskeletal function during movement. Humans must maintain their capacity to move in order to maintain quality-of-life. Predictive modelling is potentially the most powerful approach for understanding musculoskeletal function during movement. Current computational methods are too slow and unreliable to deliver predictive simulations of movement using realistic models of muscle and joint anatomy. This project expects to create the next generation of methods and algorithms needed to enable predictive modelling of movement. Predictive simulations will provide new insights into how muscles stabilise and control movements of the spine, pelvis and lower limbs during daily activities such as walking.Read moreRead less
Accurate Prediction of Safe Life of Buried Pipelines. Failures of buried pipes are disastrous, causing severe consequences and disruptions. They often reoccur because the fundamental cause-effect relation for pipe failures has not been fully understood and hence the safe life of pipelines cannot be reliably predicted. The aim of this research is to develop a new theory to predict pipe failures, based on a fundamental analysis of pipe behaviour and failure mechanisms and a reliability approach. T ....Accurate Prediction of Safe Life of Buried Pipelines. Failures of buried pipes are disastrous, causing severe consequences and disruptions. They often reoccur because the fundamental cause-effect relation for pipe failures has not been fully understood and hence the safe life of pipelines cannot be reliably predicted. The aim of this research is to develop a new theory to predict pipe failures, based on a fundamental analysis of pipe behaviour and failure mechanisms and a reliability approach. The outcomes will be a suite of models and solutions that will advance knowledge in deterioration science and failure theory. They will provide a sustainable solution to the intelligent management of buried pipelines throughout the world.Read moreRead less
Non-differentiable Energy Minimisation For Modelling Fractured Porous Media. This project is aimed at advancing theoretical, computational and experimental bases for the fracturing of geomaterials, and providing scientists and engineers with much needed predictive tools for quantitative assessment of the responses. By incorporating previously neglected aspects such as energy minimisation, advanced constitutive modelling, and non-planar interacting fracture growth, confidence in the design and pl ....Non-differentiable Energy Minimisation For Modelling Fractured Porous Media. This project is aimed at advancing theoretical, computational and experimental bases for the fracturing of geomaterials, and providing scientists and engineers with much needed predictive tools for quantitative assessment of the responses. By incorporating previously neglected aspects such as energy minimisation, advanced constitutive modelling, and non-planar interacting fracture growth, confidence in the design and planning of engineering processes in fractured porous media will be increased to the point that costly over/under designs are avoided. Through the use of the tools developed, it will be possible to detect weaknesses in the design, assess the impact and implement effective measures to improve performance.Read moreRead less
Robustness-oriented and serviceable design of innovative modular buildings. This project aims to unlock the full potential of prefabricated modular buildings through innovative framing solutions in combination with new evaluation methods to enhance serviceability and improve safety under extreme events. Advanced 3D hybrid testing and analysis will be used to create new knowledge on the complex system-level dynamic behaviour of modular buildings. The expected outcome of this project will lead to ....Robustness-oriented and serviceable design of innovative modular buildings. This project aims to unlock the full potential of prefabricated modular buildings through innovative framing solutions in combination with new evaluation methods to enhance serviceability and improve safety under extreme events. Advanced 3D hybrid testing and analysis will be used to create new knowledge on the complex system-level dynamic behaviour of modular buildings. The expected outcome of this project will lead to safe, affordable, and environmentally sustainabe modular building construction. The project will provide significant benefits to designers, manufacturers and regulators to improve the resilience of the building stock and to support greater design and manufacturing innovations.Read moreRead less
Next-generation smart water network for performance-driven asset management. This project aims to develop smart water network systems and techniques for continuous monitoring and early detection of structural failure in water distribution systems. Water assets are critical infrastructure, and they consist of a network of buried pipes that are old and deteriorating, with an annual maintenance overhead exceeding $1billion per year in Australia. This project is expected to deliver next-generation s ....Next-generation smart water network for performance-driven asset management. This project aims to develop smart water network systems and techniques for continuous monitoring and early detection of structural failure in water distribution systems. Water assets are critical infrastructure, and they consist of a network of buried pipes that are old and deteriorating, with an annual maintenance overhead exceeding $1billion per year in Australia. This project is expected to deliver next-generation smart water technology that enables continuous assessment of the actual performance of water pipe networks, guide “just in time” pipe replacement and optimise operations. This technology will assist asset managers to make informed decisions, strategically prioritise investment and extend asset life.Read moreRead less