Special Research Initiatives - Grant ID: SR0354734
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
The Australian Research Network for Medical Devices: advanced technology solutions for patients and practitioners. Medical Device technologies embrace a wide range of scientific, engineering and medical knowledge, with the goal of assisting a clinical professional (doctor or nurse) deliver a service to a patient in an efficacious, cost effective manner. Development of appropriate medical devices, whether for diagnosis, treatment or prevention of disease or disability, is critical to improving h ....The Australian Research Network for Medical Devices: advanced technology solutions for patients and practitioners. Medical Device technologies embrace a wide range of scientific, engineering and medical knowledge, with the goal of assisting a clinical professional (doctor or nurse) deliver a service to a patient in an efficacious, cost effective manner. Development of appropriate medical devices, whether for diagnosis, treatment or prevention of disease or disability, is critical to improving health care and reducing health care costs. To be successful, a device must include all relevant disciplines in the research, development and testing phases. This network will bring together these groups, promoting knowledge sharing and cross-disciplinary investigations that illuminate current device limitations and potential solutions.Read moreRead less
Modelling applications of nanomaterials in biology and medicine. This proposal will address fundamental issues related to nanomaterials and their applications in biology and medicine. Accurate mathematical models will be formulated, leading to new practical techniques in nanobiotechnology, safe and effective methods to diagnose and cure diseases including cancer via targeted drug and gene delivery, and detection methods for biological hazards, such as those arising from biological terrorism. The ....Modelling applications of nanomaterials in biology and medicine. This proposal will address fundamental issues related to nanomaterials and their applications in biology and medicine. Accurate mathematical models will be formulated, leading to new practical techniques in nanobiotechnology, safe and effective methods to diagnose and cure diseases including cancer via targeted drug and gene delivery, and detection methods for biological hazards, such as those arising from biological terrorism. The research facility proposed involves significant training of applied mathematicians at honours, PhD and postdoctoral levels and multidisciplinary collaboration, ensuring that Australia maintains and develops an expertise in nanobiotechnology well into the future.Read moreRead less
Combining the soft with the hard: The assembly of artificial cell membranes on porous semiconductors. The platform technologies developed in this project will have a wide range of applications. They will reveal new insights into drug-membrane and drug-protein interactions underpinning development of a new generation of drugs acting on transmembrane proteins that are linked to a wide range of diseases. The development of membrane-based biosensing devices targeting ion channels, membrane active pe ....Combining the soft with the hard: The assembly of artificial cell membranes on porous semiconductors. The platform technologies developed in this project will have a wide range of applications. They will reveal new insights into drug-membrane and drug-protein interactions underpinning development of a new generation of drugs acting on transmembrane proteins that are linked to a wide range of diseases. The development of membrane-based biosensing devices targeting ion channels, membrane active peptides or toxins which can be applied to biomedical diagnostics, biotoxin detection, environmental and food control will be readily achievable. This international interdisciplinary nanobiotechnology programme and its outcomes will enhance Australia's abilities in frontier technologies and build research strength in nanobiotechnology.Read moreRead less
Three-dimensional Simulation of Trabecular Bone Remodelling. Nearly 2 million Australians currently suffer from osteoporosis. Statistics indicate that 25% of Australian women and 17% of men will develop an osteoporotic fracture. The cost of osteoporosis is $7.4 billion per annum; the numbers of affected individuals and costs are expected to continue increasing. Clearly, improvements to osteoporosis diagnosis, fracture risk assessment, and effective treatments are still urgently needed. The p ....Three-dimensional Simulation of Trabecular Bone Remodelling. Nearly 2 million Australians currently suffer from osteoporosis. Statistics indicate that 25% of Australian women and 17% of men will develop an osteoporotic fracture. The cost of osteoporosis is $7.4 billion per annum; the numbers of affected individuals and costs are expected to continue increasing. Clearly, improvements to osteoporosis diagnosis, fracture risk assessment, and effective treatments are still urgently needed. The proposed project aims to create a tool for understanding the mechanisms of bone loss and predicting the effects of osteoporosis therapies. It represents a solid contribution to the knowledge base necessary for advancing osteoporosis research and ultimately reducing the incidence of osteoporotic fracture.Read moreRead less
Which Heart Failure Intervention Is Most Cost Effective In Reducing Hospital Care (WHICH? II) Trial: A Multicentre, Randomised Trial Of Standard Versus Intensified Management Of Metropolitan And Regional-dwelling Patients With Heart Failure
Funder
National Health and Medical Research Council
Funding Amount
$1,891,210.00
Summary
Chronic heart failure (CHF) management programs are now the gold-standard to cost-effectively care for thousands of Australians hospitalised with CHF each year. We’ve shown that home-based management is most cost-effective in reducing hospital stay in CHF. The Which Intervention is most Cost-effective in reducing Hospital care (WHICH? II) Trial, a multicentre, randomised study, will determine if more intensive care (via home visits and remote care contacts) further improves poor outcomes in CHF.
Development of sophisticated structural design guidelines for the new building product known as Rapidwall. Rapidwall is an Australian made new composite building product made from formulated gypsum plaster and glass-fibre. This is a high-tech building product that has huge potential to be developed into a dominant building material in the future. It is economic, labor effective, eco-friendly, structural sound and fire, thermal resistant and has many advantages over the existing building material ....Development of sophisticated structural design guidelines for the new building product known as Rapidwall. Rapidwall is an Australian made new composite building product made from formulated gypsum plaster and glass-fibre. This is a high-tech building product that has huge potential to be developed into a dominant building material in the future. It is economic, labor effective, eco-friendly, structural sound and fire, thermal resistant and has many advantages over the existing building materials, such as concrete, steel and masonry. The lack of a technical design guidelines has fundamentally obstructed it from expanding its market share both in Australia and overseas. This proposal aims at developing a structural design manual for the new product.Read moreRead less
A New Generic Approach for Assessing Blast Effects on Reinforced Concrete Members. A framework allow for both flexural and shear response analysis using a new segmental approach is developed in this proposal. A blast test program is designed to validate the framework for reinforced concrete members. The validated framework is then used to derive normalised pressure impulse programs for reinforced members in unconfined and confined spaces. This project will provide design engineers guidelines for ....A New Generic Approach for Assessing Blast Effects on Reinforced Concrete Members. A framework allow for both flexural and shear response analysis using a new segmental approach is developed in this proposal. A blast test program is designed to validate the framework for reinforced concrete members. The validated framework is then used to derive normalised pressure impulse programs for reinforced members in unconfined and confined spaces. This project will provide design engineers guidelines for reliably and quickly assessing the effect of different kinds of blast loads on different types and properties and geometries of reinforced concrete structural members, saving computation time and efforts while providing increased realism and accuracy.Read moreRead less
Experimental investigation and constitutive modelling of reactive soils. This project aims to develop the fundamental knowledge, a mechanical framework and practical engineering design tools needed to minimise the effects of reactive soils on infrastructure. Reactive soils undergo significant swelling and weakening upon wetting or intrusion by salt-rich groundwater and shrinkage upon drying. This can result in damage to buildings and infrastructure beyond a state of repair. This project will dev ....Experimental investigation and constitutive modelling of reactive soils. This project aims to develop the fundamental knowledge, a mechanical framework and practical engineering design tools needed to minimise the effects of reactive soils on infrastructure. Reactive soils undergo significant swelling and weakening upon wetting or intrusion by salt-rich groundwater and shrinkage upon drying. This can result in damage to buildings and infrastructure beyond a state of repair. This project will develop tools, models and theories to detect weaknesses in the design of infrastructure and its foundations built on problematic reactive soils, assess the impact and implement effective remedial measures to improve performance. The project is expected to increase efficiency through improved design and reduced damage, and save infrastructure owners, government and private, tens of millions of dollars each year.Read moreRead less
Combining transient micro-reflections and multi-sensor arrays for condition assessment of buried pipes. This project will develop an accurate and reliable approach for assessing the condition of pipelines. This new approach will reduce costs and save considerable amounts of water each year, as it will assist utilities in preventing major failures such as pipe bursts, and performing strategically targeted maintenance, replacement and rehabilitation.
Detecting developing cracks before pipe bursts using smart sensor systems. This project aims to significantly reduce the number of pipe bursts in cities by detecting the leaks from developing cracks on water supply pipes just in time. New techniques will be developed for reliable and timely detection using the existing sensor network in the Adelaide CBD. Specialised monitoring stations will be developed with adaptive noise-cancellation algorithms to detect small leak signals in noisy city enviro ....Detecting developing cracks before pipe bursts using smart sensor systems. This project aims to significantly reduce the number of pipe bursts in cities by detecting the leaks from developing cracks on water supply pipes just in time. New techniques will be developed for reliable and timely detection using the existing sensor network in the Adelaide CBD. Specialised monitoring stations will be developed with adaptive noise-cancellation algorithms to detect small leak signals in noisy city environments. Expected outcomes include an effective pipe burst early warning system and the implementation of an active burst prevention and targeted pipe replacement strategy. This should significantly reduce the burst rates and associated interruptions in Adelaide and save millions of dollars every year in pipe relay programs.Read moreRead less