Special Research Initiatives - Grant ID: SR0354734
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
The Australian Research Network for Medical Devices: advanced technology solutions for patients and practitioners. Medical Device technologies embrace a wide range of scientific, engineering and medical knowledge, with the goal of assisting a clinical professional (doctor or nurse) deliver a service to a patient in an efficacious, cost effective manner. Development of appropriate medical devices, whether for diagnosis, treatment or prevention of disease or disability, is critical to improving h ....The Australian Research Network for Medical Devices: advanced technology solutions for patients and practitioners. Medical Device technologies embrace a wide range of scientific, engineering and medical knowledge, with the goal of assisting a clinical professional (doctor or nurse) deliver a service to a patient in an efficacious, cost effective manner. Development of appropriate medical devices, whether for diagnosis, treatment or prevention of disease or disability, is critical to improving health care and reducing health care costs. To be successful, a device must include all relevant disciplines in the research, development and testing phases. This network will bring together these groups, promoting knowledge sharing and cross-disciplinary investigations that illuminate current device limitations and potential solutions.Read moreRead less
Modelling applications of nanomaterials in biology and medicine. This proposal will address fundamental issues related to nanomaterials and their applications in biology and medicine. Accurate mathematical models will be formulated, leading to new practical techniques in nanobiotechnology, safe and effective methods to diagnose and cure diseases including cancer via targeted drug and gene delivery, and detection methods for biological hazards, such as those arising from biological terrorism. The ....Modelling applications of nanomaterials in biology and medicine. This proposal will address fundamental issues related to nanomaterials and their applications in biology and medicine. Accurate mathematical models will be formulated, leading to new practical techniques in nanobiotechnology, safe and effective methods to diagnose and cure diseases including cancer via targeted drug and gene delivery, and detection methods for biological hazards, such as those arising from biological terrorism. The research facility proposed involves significant training of applied mathematicians at honours, PhD and postdoctoral levels and multidisciplinary collaboration, ensuring that Australia maintains and develops an expertise in nanobiotechnology well into the future.Read moreRead less
Which Heart Failure Intervention Is Most Cost Effective In Reducing Hospital Care (WHICH? II) Trial: A Multicentre, Randomised Trial Of Standard Versus Intensified Management Of Metropolitan And Regional-dwelling Patients With Heart Failure
Funder
National Health and Medical Research Council
Funding Amount
$1,891,210.00
Summary
Chronic heart failure (CHF) management programs are now the gold-standard to cost-effectively care for thousands of Australians hospitalised with CHF each year. We’ve shown that home-based management is most cost-effective in reducing hospital stay in CHF. The Which Intervention is most Cost-effective in reducing Hospital care (WHICH? II) Trial, a multicentre, randomised study, will determine if more intensive care (via home visits and remote care contacts) further improves poor outcomes in CHF.
A New Generic Approach for Assessing Blast Effects on Reinforced Concrete Members. A framework allow for both flexural and shear response analysis using a new segmental approach is developed in this proposal. A blast test program is designed to validate the framework for reinforced concrete members. The validated framework is then used to derive normalised pressure impulse programs for reinforced members in unconfined and confined spaces. This project will provide design engineers guidelines for ....A New Generic Approach for Assessing Blast Effects on Reinforced Concrete Members. A framework allow for both flexural and shear response analysis using a new segmental approach is developed in this proposal. A blast test program is designed to validate the framework for reinforced concrete members. The validated framework is then used to derive normalised pressure impulse programs for reinforced members in unconfined and confined spaces. This project will provide design engineers guidelines for reliably and quickly assessing the effect of different kinds of blast loads on different types and properties and geometries of reinforced concrete structural members, saving computation time and efforts while providing increased realism and accuracy.Read moreRead less
Experimental investigation and constitutive modelling of reactive soils. This project aims to develop the fundamental knowledge, a mechanical framework and practical engineering design tools needed to minimise the effects of reactive soils on infrastructure. Reactive soils undergo significant swelling and weakening upon wetting or intrusion by salt-rich groundwater and shrinkage upon drying. This can result in damage to buildings and infrastructure beyond a state of repair. This project will dev ....Experimental investigation and constitutive modelling of reactive soils. This project aims to develop the fundamental knowledge, a mechanical framework and practical engineering design tools needed to minimise the effects of reactive soils on infrastructure. Reactive soils undergo significant swelling and weakening upon wetting or intrusion by salt-rich groundwater and shrinkage upon drying. This can result in damage to buildings and infrastructure beyond a state of repair. This project will develop tools, models and theories to detect weaknesses in the design of infrastructure and its foundations built on problematic reactive soils, assess the impact and implement effective remedial measures to improve performance. The project is expected to increase efficiency through improved design and reduced damage, and save infrastructure owners, government and private, tens of millions of dollars each year.Read moreRead less
Combining transient micro-reflections and multi-sensor arrays for condition assessment of buried pipes. This project will develop an accurate and reliable approach for assessing the condition of pipelines. This new approach will reduce costs and save considerable amounts of water each year, as it will assist utilities in preventing major failures such as pipe bursts, and performing strategically targeted maintenance, replacement and rehabilitation.
Probiotic Prawn Oral Immunotherapy (ProPIT) For Treatment Of Prawn Allergy
Funder
National Health and Medical Research Council
Funding Amount
$1,865,369.00
Summary
A ‘curative’ food allergy treatment is needed to prevent deaths and improve care. We recently showed that probiotic peanut oral immunotherapy (PPOIT) was highly effective for treating peanut allergy. 82% of PPOIT treated children gained tolerance compared to 4% of the placebo group. We will now test the combined probiotic-food OIT approach for treating prawn allergy. If successful, we will have identified the first treatment for prawn allergy and a platform treatment for other food allergies.
Reducing Blackout Risk through Live Modelling and Monitoring. This project aims to reduce the risk of blackouts through the development of on-line systems for modelling and monitoring of loads and power system controllers. This project is a collaboration with Transgrid, Powerlink, Vencorp and ElectraNetSA, four Transmission companies renowned for innovation in the area of system stability. The project proposes to develop innovative algorithms and to implement these algorithms using advanced hard ....Reducing Blackout Risk through Live Modelling and Monitoring. This project aims to reduce the risk of blackouts through the development of on-line systems for modelling and monitoring of loads and power system controllers. This project is a collaboration with Transgrid, Powerlink, Vencorp and ElectraNetSA, four Transmission companies renowned for innovation in the area of system stability. The project proposes to develop innovative algorithms and to implement these algorithms using advanced hardware, software and communication systems to dynamically generate decision tools for safe and efficient power system operating conditions. These systems will also generate alarms if any risky operational situations arise.Read moreRead less
An In Depth Analysis Of Clinical And Virological Outcomes Of 2 Strategies For The Antiretroviral Salvage Of First-line Regimen Virological Failure For HIV-1 Infection Tested In An Australian-led Randomised, International, Multi-centre Clinical Trial
Funder
National Health and Medical Research Council
Funding Amount
$421,747.00
Summary
The recently completed Australian-led SECOND-LINE trial is the first high quality study to provide reliable evidence for policy recommendations for the composition of anti-HIV drug cocktails after standard initial treatment has failed. This award will support the researcher in further refining our understanding of how to manage second-line therapy including proposals to test the use of low-cost technologies for application in resource-limited settings where the majority of people with HIV live.
Special Research Initiatives - Grant ID: SR0354894
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Innovative risk analysis, assessment, rehabilitation and strengthening of aging critical civil infrastructure. Much essential civil engineering infrastructure such as bridges, buildings, dams, pipelines and pavements was commissioned many decades ago, and sustaining the integrity of this infrastructure in developed nations as it ages is now considered to be a major challenge to the engineering and scientific community. Australia is not spared by the ramifications of its aging civil assets, and ....Innovative risk analysis, assessment, rehabilitation and strengthening of aging critical civil infrastructure. Much essential civil engineering infrastructure such as bridges, buildings, dams, pipelines and pavements was commissioned many decades ago, and sustaining the integrity of this infrastructure in developed nations as it ages is now considered to be a major challenge to the engineering and scientific community. Australia is not spared by the ramifications of its aging civil assets, and identification and rectification procedures that are often ad-hoc now represent a sizeable proportion of the GDP. This Research Network draws together the leading Australian research groups in engineering and applied mechanics in a coordinated program to address this most important cost to the community.Read moreRead less