Forecasting The Impact Of Climate Change On Dengue Transmission
Funder
National Health and Medical Research Council
Funding Amount
$506,432.00
Summary
Dengue fever (DF) is the most important mosquito-transmitted viral disease in the world. The large-scale re-emergence of DF in the Asia-Pacific region during the past few decades has renewed its status as a serious international public health problem. Global climate change is anticipated to impact upon the biology and ecology of vectors and consequently the risk of DF transmission. The principal research aim of this study is to project the impact of future climate change on DF.
Identifying Optimal Sustainable Cooling Strategies For The Most Vulnerable During Heatwaves
Funder
National Health and Medical Research Council
Funding Amount
$1,115,640.00
Summary
Current guidance warns against electric fan use in heatwaves without any supporting evidence. This Project aims to identify how fans and other parallel low-resource strategies can reduce the risk of heat-related illness in the most vulnerable during simulated hot/humid and very hot/dry heat wave conditions. This information will be used to develop simple heat adaptation strategies that also mitigate unsustainable energy demands and the destructive environmental impact of air conditioning.
New Vectors, New Diseases: Understanding The Risk Of Chikungunya Transmission In Australia
Funder
National Health and Medical Research Council
Funding Amount
$522,580.00
Summary
Chikungunya is a febrile illness that can lead to chronic, debilitating joint pain in adults and severe neurological complications in children. Introductions of this virus into Australia have steadily increased in recent years. We will estimate the risk of chikungunya transmission in Australia now and into the future, and deliver the results to public health authorities to reduce the risk of outbreaks in Australia.
Dengue Transmission Under Climate Change In Northern Australia: Linking Ecological And Population Based Models To Develop Adaptive Strategies
Funder
National Health and Medical Research Council
Funding Amount
$444,293.00
Summary
The mosquito-transmitted viral disease, dengue, is likely to be influenced by climate change. It has been accorded priority for human health adaptation research (National Adaptation Research Plan, Human Health). Dengue has major health impacts in North Queensland, and causes major losses to the Queensland blood supply. The research will develop a model for climate-related changes in the future occurrence of dengue to predict risk in North Queensland and other parts of Australia.
Displaced Twice? Investigating The Impact Of The Queensland Floods On The Wellbeing And Settlement Of A Cohort Of Men From Refugee Backgrounds Living In Brisbane And Toowoomba
Funder
National Health and Medical Research Council
Funding Amount
$259,771.00
Summary
What can we learn from resettled refugees' ability to adapt to extreme weather disasters? Between 2008 and 2010, the SettleMEN project documented the health and settlement outcomes of 233 refugee men living in urban and regional areas of Southeast Queensland. Some of these men lived in or close to areas that were affected by the January 2011 floods. This follow-up study aims at investigating longer-term settlement and the impact of the floods on this group of refugee men and their families
Health Impacts Of Climate Change On Indigenous Australians: Identifying Climate Thresholds To Enable The Development Of Informed Adaptation Strategies
Funder
National Health and Medical Research Council
Funding Amount
$361,034.00
Summary
Closing the gap in Indigenous health and adapting to climate change are two major policy challenges for Australia. This project addresses these issues by providing quantitative and qualitative evidence of the disproportionate impacts of climate on the health of Indigenous people. This research will provide policy-relevant evidence to enable targeting of resources to develop effective climate adaptation strategies to reduce adverse health outcomes for Indigenous Australians from climate change.
6% of Australian men are infertile. Of these cases 50% are thought to be genetic in origin. Within this project we will replicate high-confidence genetic variants associated with human male infertility in the mouse. Doing so will allow the assignment of definitive genotype-phenotype correlations and the formulation of high confidence advice for clinicians and patients. It will also provide a means to define the mechanism of action and the tools for future pro-fertility treatments.
Climate Change Impacts On Workplace Heat Extremes: Health Risk Estimates And Adaptive Options
Funder
National Health and Medical Research Council
Funding Amount
$741,938.00
Summary
Global warming will bring more hot (and extremely hot) days as Australia warms within the projected range of 2-4oC by 2070. Working in the heat is uncomfortable and requires rest breaks, yet pressure to keep working risks overheating and serious health problems. We will study the current effects on health and productivity on heat exposed workers, and model future trends in likely impacts under climate change in 8 (urban and rural) regions, with and without adaptive health protection strategies.
Deciphering Mechanisms Of Disease Evolution In Melanoma
Funder
National Health and Medical Research Council
Funding Amount
$845,093.00
Summary
In many patients, cancers are ever-changing, even after they have formed. This explains why many cancers can spread beyond the point of cure by surgery and why they can become resistant to treatments. This project will use patient melanomas and laboratory modelling to understand how melanomas change as they grow and spread. The results will be used to identify the nature of evolutionary changes in cancer in order to predict and even exploit them in treatment.
Integrative Bioinformatic And Experimental Approaches To Define Novel Roles For Genes That Typically Regulate Axon Guidance In Pancreatic Cancer Initiation
Funder
National Health and Medical Research Council
Funding Amount
$587,955.00
Summary
Early detection and intervention would have a dramatic effect on improving the outcomes for pancreatic cancer. This however relies on understanding how the cancer is initiated. New analysis of more than 100 tumours identified aberrations in genes that typically regulate how the nervous system is positioned during development. We want to use novel bioinformatic approaches and a unique experimental method with cells in culture to rapidly and accurately find out which of these genes drives a normal ....Early detection and intervention would have a dramatic effect on improving the outcomes for pancreatic cancer. This however relies on understanding how the cancer is initiated. New analysis of more than 100 tumours identified aberrations in genes that typically regulate how the nervous system is positioned during development. We want to use novel bioinformatic approaches and a unique experimental method with cells in culture to rapidly and accurately find out which of these genes drives a normal pancreatic cell to become a tumour cell.Read moreRead less