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How do apicomplexan parasites steal amino acids from their hosts? The single-celled parasites that cause malaria and toxoplasmosis are adept at stealing nutrients from the host animals that they infect. How they do this is, however, poorly understood. This project seeks to identify the processes by which these parasites scavenge amino acids, an essential class of nutrient, from their hosts. Using innovative experimental approaches, the project aims to identify and characterise the parasite prote ....How do apicomplexan parasites steal amino acids from their hosts? The single-celled parasites that cause malaria and toxoplasmosis are adept at stealing nutrients from the host animals that they infect. How they do this is, however, poorly understood. This project seeks to identify the processes by which these parasites scavenge amino acids, an essential class of nutrient, from their hosts. Using innovative experimental approaches, the project aims to identify and characterise the parasite proteins that mediate the uptake of different amino acids into the parasite. The intended outcomes of the project are to provide comprehensive insights into a fundamental aspect of parasite biology, and inform strategies to treat the diseases caused by these parasites by cutting off their nutrient supply.Read moreRead less
Force-from-lipids biophysical principle underlying mechanotransduction. The major aim of this project is to determine evolutionary conserved physical principles of mechanotransduction in living cells through structure and function studies of PIEZO mechanoreceptor channels playing a crucial role in senses such as touch and pain in animals and humans. Mutations in these channels can cause numerous genetic disorders, including hereditary anaemias and joint contractures. Since they have been shown t ....Force-from-lipids biophysical principle underlying mechanotransduction. The major aim of this project is to determine evolutionary conserved physical principles of mechanotransduction in living cells through structure and function studies of PIEZO mechanoreceptor channels playing a crucial role in senses such as touch and pain in animals and humans. Mutations in these channels can cause numerous genetic disorders, including hereditary anaemias and joint contractures. Since they have been shown to respond to mechanical stimuli in the same manner as mechanoreceptor channels of organisms from bacteria to humans the intended outcome of this project is to uncover the unifying principles of mechanotransduction anchored in the laws of physics and chemistry that have guided the force-dependent design of all life forms.Read moreRead less
Autotransporter assembly: new insights and biotechnological potential. The objective of this project is to improve our understanding of a fundamental biological problem: how autotransporters are assembled into cellular membranes. Autotransporters are a large family of bacterial proteins that play key roles in the pathogenesis of several infectious diseases. Currently, the precise mechanism by which disease-causing molecules are assembled into the outer membranes of bacteria and mitochondria is p ....Autotransporter assembly: new insights and biotechnological potential. The objective of this project is to improve our understanding of a fundamental biological problem: how autotransporters are assembled into cellular membranes. Autotransporters are a large family of bacterial proteins that play key roles in the pathogenesis of several infectious diseases. Currently, the precise mechanism by which disease-causing molecules are assembled into the outer membranes of bacteria and mitochondria is poorly understood. The knowledge that the project develops may inform future strategies aimed at the rational treatment of bacterial and mitochondrial diseases.Read moreRead less
Molecular mechanisms of mechanosensation and shape regulation in cells. This project aims to explore how cells physically sense and respond to the surrounding environment on a molecular level. Physical distortion of erythrocytes doubles their glucose consumption and increases cation membrane flux five-fold. This mechanism involves opening of the mechanosenstive ion channel Piezo1. This project will include a kinetic description of these phenomena, with a goal to establish a predictive mathematic ....Molecular mechanisms of mechanosensation and shape regulation in cells. This project aims to explore how cells physically sense and respond to the surrounding environment on a molecular level. Physical distortion of erythrocytes doubles their glucose consumption and increases cation membrane flux five-fold. This mechanism involves opening of the mechanosenstive ion channel Piezo1. This project will include a kinetic description of these phenomena, with a goal to establish a predictive mathematical model of the regulation of cell-shape and volume. The project will provide an understanding of mechanisms operating when cells and tissues are succumbing to trauma and invasion, and how to control these processes on a molecular level.Read moreRead less
Genetic rescue of Australian wildlife. Genetic rescue of Australian wildlife. This project aims to test genetic rescue as an efficient recovery technique for threatened plants and animals. Genetic rescue is under-utilised, even though it is overwhelmingly beneficial. This project will convert management actions on five Endangered/Critically Endangered species into rigorous experiments that measure the fitness benefits of genetic rescue, and demonstrate genome-wide consequences. Anticipated outco ....Genetic rescue of Australian wildlife. Genetic rescue of Australian wildlife. This project aims to test genetic rescue as an efficient recovery technique for threatened plants and animals. Genetic rescue is under-utilised, even though it is overwhelmingly beneficial. This project will convert management actions on five Endangered/Critically Endangered species into rigorous experiments that measure the fitness benefits of genetic rescue, and demonstrate genome-wide consequences. Anticipated outcomes include innovative genetic rescue protocols, a framework for genetic rescue, and leading-edge conservation training. Expected benefits are increased persistence of species that are otherwise unresponsive to management, and a new path to saving endangered species.Read moreRead less
Equity and spatial reasoning in students’ mathematics development. The project aims to understand the influence of Spatial-Reasoning on school mathematics. Spatial-Reasoning skills are a significant predictor of achievement in mathematics, and will become increasingly necessary in digital and dynamic environments. Opportunities for disadvantaged students to develop such reasoning skills are limited; they are typically not taught in schools. The project investigates the role and nature of Spatial ....Equity and spatial reasoning in students’ mathematics development. The project aims to understand the influence of Spatial-Reasoning on school mathematics. Spatial-Reasoning skills are a significant predictor of achievement in mathematics, and will become increasingly necessary in digital and dynamic environments. Opportunities for disadvantaged students to develop such reasoning skills are limited; they are typically not taught in schools. The project investigates the role and nature of Spatial-Reasoning in students’ mathematics development; and substantiates the long-term effect of a spatial learning programme on educationally disadvantaged students’ mathematics performance and reasoning. This project is expected to improve disadvantaged students’ spatial reasoning and mathematics skills and their life opportunities.Read moreRead less
Linking for Life: Enhancing pathways to well-being for all Australians. The Linking for Life Project will identify pathways to wellbeing and better social outcomes across the life-course for high-risk/vulnerable individuals and their families to streamline service provision, improve outcomes and identify cost-efficiencies across government agencies. The work will expand cross-sectoral data linkage capability, enhancing research capacity to generate evidence-based policy to improve integrated ser ....Linking for Life: Enhancing pathways to well-being for all Australians. The Linking for Life Project will identify pathways to wellbeing and better social outcomes across the life-course for high-risk/vulnerable individuals and their families to streamline service provision, improve outcomes and identify cost-efficiencies across government agencies. The work will expand cross-sectoral data linkage capability, enhancing research capacity to generate evidence-based policy to improve integrated service delivery across government. The project will also trial innovative data linkage models including the creation of data repositories to improve efficiency for data provision and access, which will have application nationally and enable more timely access to whole-population linked cross-sector data.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240101245
Funder
Australian Research Council
Funding Amount
$445,047.00
Summary
Automated Modelling Assistance for the Creation of Complex Planning Models. Artificial Intelligence (AI) planning technology is used to control systems like automated factories, robots, or to solve complex optimisation problems. Creating these models is however rather complex and error-prone and requires experts to create them in the first place. This project aims at developing techniques and tools for automated modelling support. They will make the modelling process easier and guarantee desired ....Automated Modelling Assistance for the Creation of Complex Planning Models. Artificial Intelligence (AI) planning technology is used to control systems like automated factories, robots, or to solve complex optimisation problems. Creating these models is however rather complex and error-prone and requires experts to create them in the first place. This project aims at developing techniques and tools for automated modelling support. They will make the modelling process easier and guarantee desired model properties such as the desired system behaviour. The tools will thus contribute towards making the technology more easily accessible to companies that might want to deploy them, while reducing costs for doing so and increasing the quality of these models.
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Integrating fire and predator management to conserve threatened species. This project aims to empower land managers to better conserve Australia’s threatened native animals by developing decision-support approaches that facilitate integrated management of threatening processes. The project will use a combination of novel predictive models, field experiments and data syntheses to assist land managers to better conserve Australia’s threatened native fauna. This project will benefit biodiversity co ....Integrating fire and predator management to conserve threatened species. This project aims to empower land managers to better conserve Australia’s threatened native animals by developing decision-support approaches that facilitate integrated management of threatening processes. The project will use a combination of novel predictive models, field experiments and data syntheses to assist land managers to better conserve Australia’s threatened native fauna. This project will benefit biodiversity conservation by enabling more effective allocation of limited conservation resources.Read moreRead less
Social isolation and volunteering of older Chinese immigrants in Australia. This co-designed and collaborative research addresses an acute challenge since COVID-19: how to make volunteering activities more accessible to CALD immigrants who suffer from serious social isolation. The researchers will work with 5 partner organisations (POs) to study Chinese immigrants (60+) in NSW as an example. It will analyse census and GSS datasets, conduct in-depth interviews and focus groups in the settings of ....Social isolation and volunteering of older Chinese immigrants in Australia. This co-designed and collaborative research addresses an acute challenge since COVID-19: how to make volunteering activities more accessible to CALD immigrants who suffer from serious social isolation. The researchers will work with 5 partner organisations (POs) to study Chinese immigrants (60+) in NSW as an example. It will analyse census and GSS datasets, conduct in-depth interviews and focus groups in the settings of old-age care, service navigation and elderly learning. This research will produce new evidence and test the effect of peer education, and support services and policy advocacy of the POs. This research will benefit CALD older immigrants, enhance service capacity and contribute to greater social cohesion in Australia.Read moreRead less