Determination of cellular mechanisms underpinning cancer cell metastasis through integrated in vivo imaging approaches. Understanding key steps that drive the spread of cancer is critical to improve current treatment strategies. Using cutting-edge imaging technology and in vivo model systems that mimic the disease, this project will pinpoint key events that are susceptible to drug intervention and identify new therapeutic targets.
Single molecule intracellular intravital imaging of actin dynamics. The project intends to develop imaging technology to visualise fundamental processes in cells within a living animal. The focus will be on the actin cytoskeleton, a dynamic macromolecular machine involved in key cellular processes including cell structure, mobility and division. It is exquisitely sensitive to environmental perturbations, requiring it to be studied in cells in living tissue. The project aims to extend the resolut ....Single molecule intracellular intravital imaging of actin dynamics. The project intends to develop imaging technology to visualise fundamental processes in cells within a living animal. The focus will be on the actin cytoskeleton, a dynamic macromolecular machine involved in key cellular processes including cell structure, mobility and division. It is exquisitely sensitive to environmental perturbations, requiring it to be studied in cells in living tissue. The project aims to extend the resolution of live imaging to the single molecule to understand the dynamics of actin assembly with implications for cellular processes that are hijacked in diseases. It also aims to provide a novel assay that may enable testing of the impact of drugs on cellular processes in real time.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101129
Funder
Australian Research Council
Funding Amount
$425,948.00
Summary
Two-Dimensional Material Tandem Detectors for Polarimetry and Spectroscopy. The aim of this project is to leverage the fundamental advantages that two-dimensional (2D) materials could provide to vertically-stacked (tandem) photodetectors. The strong absorption, tunable bandgap and polarisation dependence that many 2D materials exhibit, provides a means by which to detect properties of light. This topic is significant because it could overcome current cost/performance issues of tandem detectors, .... Two-Dimensional Material Tandem Detectors for Polarimetry and Spectroscopy. The aim of this project is to leverage the fundamental advantages that two-dimensional (2D) materials could provide to vertically-stacked (tandem) photodetectors. The strong absorption, tunable bandgap and polarisation dependence that many 2D materials exhibit, provides a means by which to detect properties of light. This topic is significant because it could overcome current cost/performance issues of tandem detectors, enabling widespread usage. The expected project outcome is the development of a novel tandem 2D detector, which as a single detector/pixel, can extract the intensity, polarisation and wavelength region of incoming light. This would provide benefits for many future applications, including machine vision and aerial surveying.Read moreRead less
Photonic crystals at visible wavelengths. Three dimensional sculptured nano-structures made at a very high spatial resolution will open way to control light emission, propagation, and transmission at the visible wavelengths. Optically thin and transparent solar cells will be able to harvest light using structures.
Fundamental electronic transport in emerging one-dimensional nanoelectronic devices. This project aims to understand the mechanisms limiting electronic transport in one-dimensional nanoelectronic devices and structures at temperatures relevant for practical device operation. One-dimensional nanoelectronic devices will be the building blocks of future technological innovation. This project will use a characterisation approach, numerical modelling and simulation, which promise to deliver knowledge ....Fundamental electronic transport in emerging one-dimensional nanoelectronic devices. This project aims to understand the mechanisms limiting electronic transport in one-dimensional nanoelectronic devices and structures at temperatures relevant for practical device operation. One-dimensional nanoelectronic devices will be the building blocks of future technological innovation. This project will use a characterisation approach, numerical modelling and simulation, which promise to deliver knowledge and analysis tools for ongoing innovation and optimisation in semiconductor nanoelectronics.Read moreRead less
Drugging the undruggable: Development of novel technologies to selectively regulate the expression of targets driving cancer and other diseases. Transcription factors are “undruggable” targets playing a principal role driving cancer. This project will create novel therapeutic strategies to inhibit transcription factors and other elusive targets differentially expressed in diseased cells, without affecting normal tissue. It proposes to construct engineered proteins able to bind and modify specifi ....Drugging the undruggable: Development of novel technologies to selectively regulate the expression of targets driving cancer and other diseases. Transcription factors are “undruggable” targets playing a principal role driving cancer. This project will create novel therapeutic strategies to inhibit transcription factors and other elusive targets differentially expressed in diseased cells, without affecting normal tissue. It proposes to construct engineered proteins able to bind and modify specific key genes deregulated in cancer, to correct their expression and stably reprogram the phenotype of the tumour cell in a normal-like state. It outlines the engineering of novel synthetic agents to block specific protein-protein interactions in cancer cells and to induce potent tumour cell death. This work will generate novel and selective therapeutics to treat un-curable forms of tumours.Read moreRead less
A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions. This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interac ....A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions. This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interactions, which will greatly complement existing meta-omics approaches. The deliverables include a proof-of-concept system validated for gut-liver axis as well as the creation of new knowledge and framework to assimilate design thinking and advanced manufacturing to elevate tissue engineering into physiology engineering. Read moreRead less
Active channel organic transistors. The objective of our project is to create the next generation of electronic transistors based upon organic semiconductors. Specifically, the project will create devices for use in applications such as low power lighting, chemical sensing and lasers.
Ultrathin III-V Solar Cells via Crack-Assisted Layer Exfoliation. III-V semiconductors are excellent photovoltaic materials with highest demonstrated solar-to-electricity conversion efficiencies, but find limited usage in terrestrial applications due to high material and fabrication costs. This project aims to improve the cost-effectiveness of III-V solar cells by developing ultrathin III-V semiconductors via crack-assisted layer transfer approach and epitaxy-free fabrication via heterojunction ....Ultrathin III-V Solar Cells via Crack-Assisted Layer Exfoliation. III-V semiconductors are excellent photovoltaic materials with highest demonstrated solar-to-electricity conversion efficiencies, but find limited usage in terrestrial applications due to high material and fabrication costs. This project aims to improve the cost-effectiveness of III-V solar cells by developing ultrathin III-V semiconductors via crack-assisted layer transfer approach and epitaxy-free fabrication via heterojunction architectures, paving the way for cost-effective, high-efficiency, flexible solar cells. The expected outcomes include a disruptive technology for integrated photovoltaics, novel contact and passivation materials, as well as new knowledge generated in materials science and optoelectronics disciplines.Read moreRead less
Band engineered heterostructures for next generation mercury cadmium telluride infrared photodetectors. The application of unique heterostructures in mercury cadmium telluride (HgCdTe) photodetectors is proposed to address at least four problems: increase of operating temperature, passivation, multiband operation, fill factor. This ambitious project will lead to a significant step forward the HgCdTe infrared photodetector physics and technology.