Molecular Diagnosis And Therapy Of Autoimmune Disease Using Translational And Reverse Translational Approaches
Funder
National Health and Medical Research Council
Funding Amount
$2,331,372.00
Summary
We plan to translate our recent discoveries on human gene variants and molecules produced by immune cells (follicular T cells) into effective therapies for autoimmune diseases. This will involve understanding the mechanisms by which the genes and molecules regulate immune tolerance, stratifying patients with autoimmune disease using newly identified biomarkers, trialling existing biologicals according to affected molecular pathway, and taking novel targets through to commercialisation.
Comparative Effectiveness Of Breast Tomosynthesis And Mammography In Real-world Population Screening: Evidence To Underpin And Improve Breast Cancer Screening
Funder
National Health and Medical Research Council
Funding Amount
$1,851,430.00
Summary
This research addresses key evidence gaps in breast cancer screening by investigating tomosynthesis (3D mammography) versus standard 2D mammography screening to establish the effectiveness of tomosynthesis in Australia and internationally, including impact on cancers not detected at screening that progress clinically. Large-scale studies will be done in real world screening services including a prospective comparative study planned collaboratively with BreastScreen to guide screening policy.
A Vision Of Healthy Urban Design For NCD Prevention
Funder
National Health and Medical Research Council
Funding Amount
$608,911.00
Summary
We are living in a new city era with new risks for health, and new ways to understand them. This project will combine state-of-the art methods in computer vision and artificial intelligence alongside co-creation of a web-based toolkit for action for use by city planners and urban designers that demonstrate practical pathways Improving our understanding of the strengths and limitations of existing city designs to ensure they are safe, clean, healthy, and sustainable.
Optimizing Immunotherapy Treatment For Breast Cancer Patients
Funder
National Health and Medical Research Council
Funding Amount
$1,938,014.00
Summary
The first steps in introducing immunotherapy for breast cancer patients have been taken in 2019. However, there is much work to do optimize immunotherapy for all breast cancer patients. My research, involving both lab and clinical trials, will develop new treatment strategies and identify new biomarkers to distinguish responders and non-responders. This will allow individualised selection of patients for evaluation of different immunotherapy approaches, with the aim of improving their survival.
Fabrication of silicon solar cells in a Lunar-like vacuum environment. In-situ power generation on the Moon is essential for the advancement of space exploration and habitation. At present this involves transportation of solar cells to the Moon. This proposal aims to pave the way for manufacture of solar cells on the Moon from Lunar materials. Utilising the future extraction and purification of silicon, abundant in lunar regolith, the project will focus on fabrication of silicon solar cells. Thi ....Fabrication of silicon solar cells in a Lunar-like vacuum environment. In-situ power generation on the Moon is essential for the advancement of space exploration and habitation. At present this involves transportation of solar cells to the Moon. This proposal aims to pave the way for manufacture of solar cells on the Moon from Lunar materials. Utilising the future extraction and purification of silicon, abundant in lunar regolith, the project will focus on fabrication of silicon solar cells. This will provide power for: water mining, oxygen extraction, vehicles and habitats on the Moon and delivery of materials to Low Earth Orbit. The proposed research aims to develop solar cells that can be manufactured on the Moon, using materials abundant there, and techniques exploiting the natural vacuum of space.Read moreRead less
Engineering stable, efficient perovskite solar cells. This project aims to address and resolve a critical issue facing perovskite solar cells which have enormous potential as a future technology for the large-scale generation of cheap, clean electricity: their instability under actual operating conditions. The project is expected to make significant fundamental advances in compositional, structural and interface engineering. This project will benefit the environment by paving the way for the wi ....Engineering stable, efficient perovskite solar cells. This project aims to address and resolve a critical issue facing perovskite solar cells which have enormous potential as a future technology for the large-scale generation of cheap, clean electricity: their instability under actual operating conditions. The project is expected to make significant fundamental advances in compositional, structural and interface engineering. This project will benefit the environment by paving the way for the widespread adoption of cheaper and more efficient solar cells.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100812
Funder
Australian Research Council
Funding Amount
$425,888.00
Summary
Is degradation of photovoltaic modules predictable and preventable? This project aims to determine the fundamental properties of the hydrogen related defect causing degradation of commercial solar modules and develop models to predict its impact. The defect causes up to 16% power loss and is likely to affect all photovoltaics due to the universal behaviour of hydrogen in semiconductors. Through new techniques combining deuterium (heavy hydrogen) and machine learning, the key project outcomes are ....Is degradation of photovoltaic modules predictable and preventable? This project aims to determine the fundamental properties of the hydrogen related defect causing degradation of commercial solar modules and develop models to predict its impact. The defect causes up to 16% power loss and is likely to affect all photovoltaics due to the universal behaviour of hydrogen in semiconductors. Through new techniques combining deuterium (heavy hydrogen) and machine learning, the key project outcomes are new knowledge of hydrogen behaviour, mitigation of degradation and predictive models to test and forecast the future output of affected modules. This is critical for system design and reliability, manufacturer warranty terms, investor returns, consumer confidence, and ultimately mitigating the climate crisis.Read moreRead less
Reducing Colorectal Cancer Burden In Young Adults: Precision Prevention And Early Detection
Funder
National Health and Medical Research Council
Funding Amount
$1,449,800.00
Summary
Bowel cancer rate in young adults before age 50 is increasing worldwide including Australia. Since it is impossible to screen everyone, it is critical to identify who is likely to develop the disease, to optimise screening. Using the world's largest resource for young-onset bowel cancer, I will conduct studies to generate high-quality evidence to inform how to best prevent bowel cancer in young adults and translate into the policy and practice, to reduce colorectal cancer burden in young adults.
Degradation of atomically dispersed M-N-C carbon catalysts in acidic media. This project aims to provide a clear understanding of the degradation mechanisms of transition metal (M) and nitrogen (N) co-doped carbon (M-N-C) catalysts in acidic media by utilising new model catalysts, standardised degradation tests, comprehensive catalyst characterisation, and machine learning tools to interrogate mechanistic hypotheses and link degradation mechanisms to specific catalyst characteristics. This proje ....Degradation of atomically dispersed M-N-C carbon catalysts in acidic media. This project aims to provide a clear understanding of the degradation mechanisms of transition metal (M) and nitrogen (N) co-doped carbon (M-N-C) catalysts in acidic media by utilising new model catalysts, standardised degradation tests, comprehensive catalyst characterisation, and machine learning tools to interrogate mechanistic hypotheses and link degradation mechanisms to specific catalyst characteristics. This project expects to generate new knowledge on rationally designing robust hydrogen fuel cell catalysts. This will provide significant benefits, such as new knowledge on catalyst degradation, new catalysts for energy conversion applications, and collaborations with the industry to accelerate Australia’s shift to renewable energy.Read moreRead less