The Role Of Melanoma Tumour Antigen P97 (Melanotransferrin) In Melanoma Tumourigenesis.
Funder
National Health and Medical Research Council
Funding Amount
$563,242.00
Summary
The Role of Melanoma Tumour Antigen p97 (Melanotransferrin) in Melanoma Tumourigenesis Melanotransferrin (MTf) is a homologue of the iron transport protein, transferrin, and was one of the first well characterised melanoma tumour antigens. Our published studies have shown that MTf plays an important role in melanoma tumourigenesis in vivo. In this proposal, we will assess if it is associated with melanoma progression in patient samples and examine its role in melanoma growth and metastasis.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100233
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
Characterisation of infrared imaging technologies. This project aims to establish a facility for two-dimensional (2D) infrared sensor array testing and prototyping. Systematic characterisation and prototyping of 2D imaging arrays is vital in showcasing and realising Australia's innovation and research investment in photodetector technologies. This facility will enable research on 2D imaging arrays, such as pixel yield and cross-talk, device reliability physics, failure mechanisms, noise and long ....Characterisation of infrared imaging technologies. This project aims to establish a facility for two-dimensional (2D) infrared sensor array testing and prototyping. Systematic characterisation and prototyping of 2D imaging arrays is vital in showcasing and realising Australia's innovation and research investment in photodetector technologies. This facility will enable research on 2D imaging arrays, such as pixel yield and cross-talk, device reliability physics, failure mechanisms, noise and long-term stability. The facility will demonstrate Australia's innovative imaging technologies, applicable in science, industry, defence and security, attracting interest from both Australian and international industries.Read moreRead less
Pharmacology Of Potential Anti-Tumour Agents: Iron Chelators Of The BpT Class
Funder
National Health and Medical Research Council
Funding Amount
$585,455.00
Summary
Pharmacology of Potential Anti-Tumour Agents: Iron Chelators of the BpT Class Cancer cells have a high iron requirement for DNA synthesis and many clinical trials showed Fe chelators are effective anti-cancer drugs. Their potential to act as anti-tumour agents has been confirmed by the entrance of Triapine into widespread NCI clinical trials. In this NHMRC Renewal, we will perform pharmacological and preclinical studies to promote the development of BpT chelators as novel anti-tumour agents.
Navigating tipping points in complex dynamical systems. This project aims to use applied mathematics to investigate the onset of tipping points in dynamical systems. Working with clinicians and practicing engineers, the project aims to contribute to the development of new treatment regimes for dynamical diseases and develop improved management strategies for resource focussed engineering industries. This should provide significant benefit to many areas, including the personalised treatment of di ....Navigating tipping points in complex dynamical systems. This project aims to use applied mathematics to investigate the onset of tipping points in dynamical systems. Working with clinicians and practicing engineers, the project aims to contribute to the development of new treatment regimes for dynamical diseases and develop improved management strategies for resource focussed engineering industries. This should provide significant benefit to many areas, including the personalised treatment of disease.Read moreRead less
Fundamental electronic transport in emerging one-dimensional nanoelectronic devices. This project aims to understand the mechanisms limiting electronic transport in one-dimensional nanoelectronic devices and structures at temperatures relevant for practical device operation. One-dimensional nanoelectronic devices will be the building blocks of future technological innovation. This project will use a characterisation approach, numerical modelling and simulation, which promise to deliver knowledge ....Fundamental electronic transport in emerging one-dimensional nanoelectronic devices. This project aims to understand the mechanisms limiting electronic transport in one-dimensional nanoelectronic devices and structures at temperatures relevant for practical device operation. One-dimensional nanoelectronic devices will be the building blocks of future technological innovation. This project will use a characterisation approach, numerical modelling and simulation, which promise to deliver knowledge and analysis tools for ongoing innovation and optimisation in semiconductor nanoelectronics.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100016
Funder
Australian Research Council
Funding Amount
$3,123,492.00
Summary
ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therap ....ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therapeutics. The use of an individual patient’s cellular and molecular research findings will ultimately enable personalised diagnostic and therapeutic decisions.Read moreRead less
Transforming Microgrid to Virtual Power Plant –ICT Frameworks,Tools,Control. The project aims to enhance large scale renewable penetrations to national power grid by advancing control, optimization, and ancillary services of Virtual Power Plants (VPPs), considering different disruptive events including recent South Australian blackout. This project expects to create new control, frame communication architecture, develop plug and play type IoT enabled grid interfacing inverter, and optimize resou ....Transforming Microgrid to Virtual Power Plant –ICT Frameworks,Tools,Control. The project aims to enhance large scale renewable penetrations to national power grid by advancing control, optimization, and ancillary services of Virtual Power Plants (VPPs), considering different disruptive events including recent South Australian blackout. This project expects to create new control, frame communication architecture, develop plug and play type IoT enabled grid interfacing inverter, and optimize resource management for distributed VPPs. The anticipated benefits from this institutional level collaborations are that VPPs help in enhancing national power grid operations during normal and disruptive conditions when more renewables are connected and also secure benefits of consumers, prosumers, and grid operators.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100134
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Integrated photodetector array fabrication facility. Sensing is becoming a ubiquitous requirement for nearly all physical, chemical and biological research fields, and is increasingly important for Australia's national security and industry competitiveness. This proposal is aimed at building Australia's strengths in optoelectronic sensing technologies, enhancing and enabling research and technologies for innovative environmental monitoring, medical diagnostics, new technologies for mineral expl ....Integrated photodetector array fabrication facility. Sensing is becoming a ubiquitous requirement for nearly all physical, chemical and biological research fields, and is increasingly important for Australia's national security and industry competitiveness. This proposal is aimed at building Australia's strengths in optoelectronic sensing technologies, enhancing and enabling research and technologies for innovative environmental monitoring, medical diagnostics, new technologies for mineral exploration and improved evaluation of remediation of mine sites, through to the surveillance and sensing needs of customs, defence and national security. In doing so, it will enhance Australia's research profile as one of the world's leaders in the development and use of optoelectronic sensing.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100125
Funder
Australian Research Council
Funding Amount
$837,000.00
Summary
National Facility for Infrared Technologies. This project aims to establish a national facility for infrared (IR) technologies. The facility will include advanced imaging and spectroscopy facilities as well as unique tools for wafer-scale mapping of IR materials and devices. Combined, the facility will enable new diagnostic capabilities of supersonic combustion processes, aid establishment of wavelength agile integrated photonic chips and provide non-destructive quantitative electro-optical char ....National Facility for Infrared Technologies. This project aims to establish a national facility for infrared (IR) technologies. The facility will include advanced imaging and spectroscopy facilities as well as unique tools for wafer-scale mapping of IR materials and devices. Combined, the facility will enable new diagnostic capabilities of supersonic combustion processes, aid establishment of wavelength agile integrated photonic chips and provide non-destructive quantitative electro-optical characterisation of IR materials and devices. Establishment of these state-of-the-art capabilities across Australia will have clear benefits in fundamental sciences such as astronomy and quantum information as well as key industry branches in defence, aerospace, communications and security.Read moreRead less
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less