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Long Term Sequelae Of Acute Kidney Injury: Identifying The Optimal Model Of Care And Intervention To Enhance Patient Outcome
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Acute kidney injury (AKI) is associated with significant morbidity, mortality and health care costs. It is increasingly recognised as a key driver of progressive kidney disease, and no intervention has been shown to improve the long-term outcome of AKI survivors. This project identifies risk factors for chronic kidney disease, dialysis dependence and death after an episode of AKI, and examines the feasibility, efficacy, and cost-effectiveness of early nephrology review in high risk individuals.
Chronic Kidney Disease And Cardiovascular Disease In Aboriginal Children And Young Adults
Funder
National Health and Medical Research Council
Funding Amount
$111,232.00
Summary
Aboriginal Australians are burdened with a higher level of chronic kidney disease and cardiovascular disease, which is the greatest contributor to the gap in health between Aboriginal and non-Aboriginal Australians. My proposed research aims identify if the increased risk of chronic disease is evident during childhood and adolescence amongst Aboriginal Australians, and to explore if this inequity is largely explained by the social determinants of health.
Cardiovascular Disease; Priorities And Outcomes For People With Chronic And End Stage Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$81,976.00
Summary
This thesis will investigate the patterns, causes and effects of heart disease in chronic kidney disease patients; how heart disease impacts on hospital admission patterns and mortality over time. We will explore the relationship between cognition, cardiovascular and kidney disease; the impact on patient outcomes and quality of life. Finally, we will explore how current research funding reflects disease burden, research output and the stated priorities of patients with chronic kidney disease.
The burden of kidney disease in Australia is rising. Differences in the burden, patterns of care and outcomes of kidney disease for people in rural and urban regions, along with the tools to address these differences, remain poorly understood. Research exploring patient, provider and health system barriers to equitable care is required if health outcomes are to improve.
Successful Prevention Of Chronic Disease Progression Among Aboriginal And Torres Strait Islander Adults In Rural North Queensland Primary Health Care Services
Funder
National Health and Medical Research Council
Funding Amount
$23,908.00
Summary
This study will examine what factors are associated with better diabetes outcomes in Indigenous Australians living in a remote community.
Therapeutic Blockade Of Complement Inducing Inflammatory Injury In Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$133,181.00
Summary
ANCA associated vasculitis is an inflammatory disease involving the kidney filters which is a major cause of chronic kidney failure. Current drugs to treat it are toxic. Less toxic treatments are required. In this study we will explore the potential for new treatments targeting complement (a normal blood protein involved in inflammation) to attenuate this disease in mice. We hope to define the role of complement in this disease and the benefits of inhibiting it before we use it in humans.
Kidney transplantation is a life-saving treatment for most people with end-stage kidney disease. For some people, however, it causes more harm than good. We will clarify which individuals will benefit from transplantation by personalising information on predicting potential outcomes after transplantation. We will use this to develop a decision tool to help doctors and patients make these challenging and irreversible decisions. This will maximise the benefits from this precious resource.
Chronic Kidney Disease: Natural History Of Disease, Cost And Quality Of Life
Funder
National Health and Medical Research Council
Funding Amount
$72,281.00
Summary
Chronic kidney disease (CKD) is present in 12% of Australians aged over 25. CKD is associated with poor health outcomes including cardiovascular disease and progression to End Stage Kidney Disease. Many questions about CKD remain. My research aims to increase our understanding of the natural history of CKD in the Australian population, with focus on outcomes of CKD progression, cardiovascular and all-cause mortality, quality of life, and costs to society.
The Prevalence And Trajectory Of Kidney Disease In Urban Aboriginal Children
Funder
National Health and Medical Research Council
Funding Amount
$94,515.00
Summary
The Study of Environment and Aboriginal Resilience on Child Health is a major NHMRC funded project looking at the health and illness of urban Aboriginal children in Australia. By working together with Aboriginal Community Controlled Health Services across urban and large regional centres in NSW the study team hope to better understand the causes of common diseases such as kidney and heart disease, and whether these first begin in childhood.
Phosphate And Fibroblast Growth Factor 23 (FGF-23) In Early Chronic Kidney Disease – Their Importance In Bone Mineral Metabolism And As Cardiovascular Risk Factors.
Funder
National Health and Medical Research Council
Funding Amount
$140,949.00
Summary
In the chronic kidney disease (CKD) population, serum phosphate and fibroblast growth factor-23 (FGF-23), a phosphate regulating hormone, are strongly associated with mortality and cardiovascular disease (CVD). This thesis will examine phosphate homeostasis in clinical studies necessary to address this problem, as phosphate and FGF-23 are potential therapeutic targets.