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ARC Centre of Excellence in Plant Cell Wall Biology. The ARC Centre for Plant Cell Wall Biology will define the regulatory mechanisms that control molecular, enzymic and cellular processes involved in the synthesis, deposition, re-modelling and depolymerisation of cell wall polysaccharides of cereals and grasses. Plant cell walls represent the world's largest renewable carbon resource, but the regulatory mechanisms responsible for their synthesis and assembly are not understood. Key distinguishi ....ARC Centre of Excellence in Plant Cell Wall Biology. The ARC Centre for Plant Cell Wall Biology will define the regulatory mechanisms that control molecular, enzymic and cellular processes involved in the synthesis, deposition, re-modelling and depolymerisation of cell wall polysaccharides of cereals and grasses. Plant cell walls represent the world's largest renewable carbon resource, but the regulatory mechanisms responsible for their synthesis and assembly are not understood. Key distinguishing features of the Centre will be the international, integrative, and multidisciplinary approach towards addressing major questions in plant biology, its strategy to leverage ARC funding, and its linkages with potential national and international end-users of the fundamental scientific discoveries.Read moreRead less
Redirecting Carbon Flow through Mesophyll and Bundle Sheath Cells of Sugarcane to Produce Poly-3-Hydroxybutyrate. This project is part of the National Priorities "Frontier Technologies for Building and Transforming Australian Industries." Using innovative plant metabolic engineering technologies combined with sophisticated computer modeling we are generating green plants that produce renewable, biodegradable, bioplastics possessing properties such that they are suitable replacements for petrol ....Redirecting Carbon Flow through Mesophyll and Bundle Sheath Cells of Sugarcane to Produce Poly-3-Hydroxybutyrate. This project is part of the National Priorities "Frontier Technologies for Building and Transforming Australian Industries." Using innovative plant metabolic engineering technologies combined with sophisticated computer modeling we are generating green plants that produce renewable, biodegradable, bioplastics possessing properties such that they are suitable replacements for petroleum-derived products in many applications. During the course of these studies, we are increasing our basic level of understanding of plant metabolism of important bioenergy crops. The production of renewable, bioplastics in sugarcane will help to diversify the Australian sugarcane industry by providing a value-added product with significant world-wide markets.Read moreRead less
Transcription factor – enhancer – promoter based regulatory networks. This project aims to develop new understanding on how multicellular organisms (including humans) develop, and how mutations in distant regions of the genome can affect human traits. The way the human genome is interpreted by the cellular machinery is still a mystery. We have a reference sequence and know where the majority of coding genes are, but we are far from understanding how the genome is regulated to generate the divers ....Transcription factor – enhancer – promoter based regulatory networks. This project aims to develop new understanding on how multicellular organisms (including humans) develop, and how mutations in distant regions of the genome can affect human traits. The way the human genome is interpreted by the cellular machinery is still a mystery. We have a reference sequence and know where the majority of coding genes are, but we are far from understanding how the genome is regulated to generate the diversity of cell types in our bodies. Enhancer regions interact with proximal promoters to regulate gene expression level and tissue-specificity. This project aims to develop transcriptional regulatory network models using high throughput chromatin interaction data and expression perturbation to link promoter and enhancers genome-wide.Read moreRead less
Towards high efficiency biofuel systems: a molecular resolution three-dimensional atlas of the photosynthetic machinery of a high-efficiency green algae cell. Solar-powered single-cell green-algae systems represent a powerful and environmentally friendly biotechnology used to produce clean fuels, food and high value products. This project is focused on solving the three-dimensional structure of key components of the photosynthetic machinery to improve the efficiency and profitability of advance ....Towards high efficiency biofuel systems: a molecular resolution three-dimensional atlas of the photosynthetic machinery of a high-efficiency green algae cell. Solar-powered single-cell green-algae systems represent a powerful and environmentally friendly biotechnology used to produce clean fuels, food and high value products. This project is focused on solving the three-dimensional structure of key components of the photosynthetic machinery to improve the efficiency and profitability of advance microalgae production systems.Read moreRead less
Bioengineering High Efficiency Solar Driven H2 Production. The project aims to bio-engineer high-efficiency microalgae cell-lines that can drive solar powered H2 production from water. It plans to do so by increasing proton and electron supply to the H2-producing hydrogenase. It builds on patented cell lines that have enhanced light capture efficiency and H2 production capabilities. The aim of this project is to increase the efficiency of the last stage of the process (three fold) in a major ste ....Bioengineering High Efficiency Solar Driven H2 Production. The project aims to bio-engineer high-efficiency microalgae cell-lines that can drive solar powered H2 production from water. It plans to do so by increasing proton and electron supply to the H2-producing hydrogenase. It builds on patented cell lines that have enhanced light capture efficiency and H2 production capabilities. The aim of this project is to increase the efficiency of the last stage of the process (three fold) in a major step in developing economic solar-fuel systems. National benefits include the development of advanced microalgae fuels systems to increase future fuel security, reduce CO2 emissions and assist with regional development.Read moreRead less
A tale of two genomes: integrating mitochondrial biogenesis into the cell cycle and metabolic control. The human genome is cordoned into two distinct compartments in our cells. Most genes are in the nucleus, while a distinct set of genes are held within our mitochondria. Using yeast as a model organism, this project will provide a holistic view of how expression of the two genomes is coordinated.
The structure in four-dimensions of a mammalian nuclear body. The project aims to develop a working model of a micron-sized molecular machine implicated in numerous aspects of gene regulation. Bodies in the mammalian cell nucleus are larger than macromolecular complexes and smaller than organelles. Recent developments in structural, molecular and cell biology are allowing us to begin to interpret their structure-function relationships. This project capitalises on a wealth of structural and funct ....The structure in four-dimensions of a mammalian nuclear body. The project aims to develop a working model of a micron-sized molecular machine implicated in numerous aspects of gene regulation. Bodies in the mammalian cell nucleus are larger than macromolecular complexes and smaller than organelles. Recent developments in structural, molecular and cell biology are allowing us to begin to interpret their structure-function relationships. This project capitalises on a wealth of structural and functional data on nuclear bodies termed paraspeckles with the aim of developing a structural model. It aims to track tens of proteins and long non-coding RNA from paraspeckles as they proceed through the cell cycle, by combining genome engineering, super-resolution microscopy, proteomics and in vitro interaction studies.Read moreRead less
Mechanisms of gene regulation. This project aims to determine the molecular basis of specific gene targeting. Transcription factor complexes regulate gene expression by binding to DNA at specific sites, modifying and looping chromatin, and recruiting the basal transcription machinery. Using blood cell transcription factor complexes as a model, this project will reveal interactions between sets of proteins that fine-tune DNA binding and recruit accessory proteins that regulate gene expression. Th ....Mechanisms of gene regulation. This project aims to determine the molecular basis of specific gene targeting. Transcription factor complexes regulate gene expression by binding to DNA at specific sites, modifying and looping chromatin, and recruiting the basal transcription machinery. Using blood cell transcription factor complexes as a model, this project will reveal interactions between sets of proteins that fine-tune DNA binding and recruit accessory proteins that regulate gene expression. The mechanistic detail provided is expected to inform the artificial up- or down-regulation of genes in biotechnological applications and ultimately treat disease which have a genetic component.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101096
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
Evolutionary Adaptation of the Chemical Language of Nutrient Acquisition Strategies in Higher Plants. The autotrophic and sessile nature of plants means that they need to respond to nutrient limitations in a finely tuned manner to grow and survive. Metabolites play an important role during these adaptations, either as direct modulators or as biochemical indicators of the pathways activated. Plants have evolved from relatively simple unicellular organisms that have a remarkable adaptability to re ....Evolutionary Adaptation of the Chemical Language of Nutrient Acquisition Strategies in Higher Plants. The autotrophic and sessile nature of plants means that they need to respond to nutrient limitations in a finely tuned manner to grow and survive. Metabolites play an important role during these adaptations, either as direct modulators or as biochemical indicators of the pathways activated. Plants have evolved from relatively simple unicellular organisms that have a remarkable adaptability to respond to their environment through metabolite-modulated quorum-sensing mechanisms. Preliminary evidence suggests that plants have either retained some of this ability or have evolved novel nutrient recognition strategies. This project will elucidate these pathways to gain new insights into nutrient acquisition in plants.Read moreRead less