A Randomised Controlled Trial (RCT) Of Azithromycin Versus Doxycycline For The Treatment Of Rectal Chlamydia Infection In Men Who Have Sex With Men.
Funder
National Health and Medical Research Council
Funding Amount
$797,906.00
Summary
Rectal chlamydia is very common among gay men; it can exist for long periods without symptoms leading to ongoing transmission. Azithromycin (1 gram single dose) or 7 days doxycycline (100mg twice daily) are the two recommended treatments globally. But, there is concern about rectal chlamydia treatment with reports of up to 22% failure following azithromycin. We will conduct a randomised trial to compare these treatments for rectal chlamydia and determine which drug works better.
Should Australia Introduce A National Chlamydia Testing Program? Evaluation Of A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$518,510.00
Summary
Chlamydia is a very common sexually transmissible infection that can lead to infertility in women. About 4% of young adults have it, yet most are unaware they have it. Chlamydia is easy to diagnose and treat, but it is not known whether annual testing can reduce its spread. Over1 million tests are conducted each year in general practice, costing the government $30 million. This evaluation of a well-established trial of chlamydia testing in young adults will resolve the debate of whether annual t ....Chlamydia is a very common sexually transmissible infection that can lead to infertility in women. About 4% of young adults have it, yet most are unaware they have it. Chlamydia is easy to diagnose and treat, but it is not known whether annual testing can reduce its spread. Over1 million tests are conducted each year in general practice, costing the government $30 million. This evaluation of a well-established trial of chlamydia testing in young adults will resolve the debate of whether annual testing works and is a good use of money.Read moreRead less
A Population-based Record Linkage Study Of The Impact Of Chlamydia Infection On Reproductive Health In Women
Funder
National Health and Medical Research Council
Funding Amount
$405,114.00
Summary
Chlamydia is the most commonly notified infection in young Australian women and reports of cases are increasing. While chlamydia is thought to result in infertility and ectopic pregnancy in later life, the evidence for this is limited. This will be the largest, most comprehensive study in the world to determine the risk of infertility and ectopic pregnancy following chlamydia infection. The results will provide vital information to more cost-effectively plan strategies to control chlamydia in Au ....Chlamydia is the most commonly notified infection in young Australian women and reports of cases are increasing. While chlamydia is thought to result in infertility and ectopic pregnancy in later life, the evidence for this is limited. This will be the largest, most comprehensive study in the world to determine the risk of infertility and ectopic pregnancy following chlamydia infection. The results will provide vital information to more cost-effectively plan strategies to control chlamydia in Australia.Read moreRead less
Surveillance Of LGV Chlamydia Trachomatis Types Among Men Who Have Sex With Men (MSM)
Funder
National Health and Medical Research Council
Funding Amount
$194,875.00
Summary
Chlamydia is a common sexually transmitted infection (STI) caused by the bacterium, Chlamydia trachomatis (CT). Annually, 50 million new cases of chlamydia are estimated to occur worldwide which if untreated, can lead to serious complications such as pelvic inflammatory disease and infertility in women and epididymitis in men. Over the past decade, there has been a sharp increase in diagnoses of chlamydia in Australia, coinciding with a reported upsurge in sexual risk behaviour (increased partne ....Chlamydia is a common sexually transmitted infection (STI) caused by the bacterium, Chlamydia trachomatis (CT). Annually, 50 million new cases of chlamydia are estimated to occur worldwide which if untreated, can lead to serious complications such as pelvic inflammatory disease and infertility in women and epididymitis in men. Over the past decade, there has been a sharp increase in diagnoses of chlamydia in Australia, coinciding with a reported upsurge in sexual risk behaviour (increased partner numbers and-or practices of unprotected sex), particularly among men who have sex with men (MSM). In addition, there are current outbreaks of an invasive CT strain, causing lymphogranuloma venereum (LGV), throughout Western Europe, with cases now reported in the USA. LGV can lead to severe anogenital ulcers, which can increase transmission of HIV, hepatitis C, and other STIs. With growing international travel, the likelihood of LGV outbreaks in Australia, particularly in MSM, is increased. Recently, isolated cases of LGV have been noted in MSM attending Sydney and Melbourne Sexual Health Centres, indicating LGV is possibly already in circulation. Since we know little about circulating CT types in Australia it would be difficult to assess the burden of an LGV outbreak. Due to increasing CT infections and likely risk of increased HIV transmission, particularly with LGV strains, surveillance of CT genotypes in Australia, especially in MSM, is important. The purpose of this study is to type CT strains in our population by looking at their genetic makeup. CT-positive specimens from Melbourne and Sydney will be used to identify CT types in circulation and to assess if LGV types are present. The knowledge obtained from this study will be novel and invaluable, and could contribute considerably to the development of improved disease prevention and intervention strategies, including the design of vaccines.Read moreRead less
A Randomised Controlled Trial To Evaluate The Effectiveness And Cost-effectiveness Of Chlamydia Testing In General Practice.
Funder
National Health and Medical Research Council
Funding Amount
$1,377,557.00
Summary
Chlamydia is a very common sexually transmissible infection in Australia that can lead to infertility in women. About 4% of young adults have it. Most people with chlamydia do not have any symptoms and will be unaware they have it. Chlamydia is easy to diagnose and treat, but it is not known whether regular testing can reduce its spread. We propose to conduct a trial to evaluate whether annual testing for 16 to 29 year olds works and whether it would be a good use of public health funds.
Sexually Transmissible Infections: Outcomes And Interventions.
Funder
National Health and Medical Research Council
Funding Amount
$568,892.00
Summary
Professor Basil Donovan, Head of the Sexual Health Program at UNSW's Kirby Institute, works on a wide range of research endeavours that are aimed at (a) better characterising the causes of sexually transmissible infections (STIs) and their outcomes, (b) determining how they move through populations, and (c) trialing interventions to bring them under control. He has a particular interest in populations that are at increased risk of STIs such as Aboriginal and Torres Strait Islander people, gay me ....Professor Basil Donovan, Head of the Sexual Health Program at UNSW's Kirby Institute, works on a wide range of research endeavours that are aimed at (a) better characterising the causes of sexually transmissible infections (STIs) and their outcomes, (b) determining how they move through populations, and (c) trialing interventions to bring them under control. He has a particular interest in populations that are at increased risk of STIs such as Aboriginal and Torres Strait Islander people, gay men, sex workers, prisoners, and youth.Read moreRead less