Specificity Of Chlamydia Pneumoniae For Humans : Analysis Of Previous Cross-host Transmission Events And The Role Of Tryptophan Availability In Host Specificity
Funder
National Health and Medical Research Council
Funding Amount
$413,568.00
Summary
Chlamydia are major causes of sexually transmitted disease but they also cause respiratory disease (Chlamydia pneumoniae) which is widespread across Australia and indeed the whole world (80% of people have been infected at some time in their life). Recent results suggest that the respiratory infections in humans came from animals and in this project we aim to identify which animals might have transmitted this infection to humans and determine if there is a continuing risk. We also plan to determ ....Chlamydia are major causes of sexually transmitted disease but they also cause respiratory disease (Chlamydia pneumoniae) which is widespread across Australia and indeed the whole world (80% of people have been infected at some time in their life). Recent results suggest that the respiratory infections in humans came from animals and in this project we aim to identify which animals might have transmitted this infection to humans and determine if there is a continuing risk. We also plan to determine what defines animal versus human infections.Read moreRead less
Persistent Chlyamdial Infection In The Testes : Development Of A Successful Vaccine Strategy For Males
Funder
National Health and Medical Research Council
Funding Amount
$652,019.00
Summary
Males are a reservoir of infection and novel vaccine approaches to control Chlamydia infections in young men are needed urgently. This study will be essential for the development of interventions to control infection and will inform strategies for manipulating the immune system within the male reproductive tract that may be applied to other sexually transmitted pathogens. The studies will benefit the health and welfare of the Australian people under National Research Priority 2, promoting and ma ....Males are a reservoir of infection and novel vaccine approaches to control Chlamydia infections in young men are needed urgently. This study will be essential for the development of interventions to control infection and will inform strategies for manipulating the immune system within the male reproductive tract that may be applied to other sexually transmitted pathogens. The studies will benefit the health and welfare of the Australian people under National Research Priority 2, promoting and maintaining good health and a healthy start to life.Read moreRead less
Genital Chlamydia infections have increased over 4-fold in the last decade. Untreated infections lead to pelvic inflammatory disease, ectopic pregnancy and infertility. These conditions are due to the inflammatory immune response elicited by infections that cause scarring and oviduct blockage. The proposed studies will determine how the immune system causes tissue damage and how this damage can be avoided to enable the development a vaccine that protects women against infection and infertility.
A Randomised Controlled Trial (RCT) Of Azithromycin Versus Doxycycline For The Treatment Of Rectal Chlamydia Infection In Men Who Have Sex With Men.
Funder
National Health and Medical Research Council
Funding Amount
$797,906.00
Summary
Rectal chlamydia is very common among gay men; it can exist for long periods without symptoms leading to ongoing transmission. Azithromycin (1 gram single dose) or 7 days doxycycline (100mg twice daily) are the two recommended treatments globally. But, there is concern about rectal chlamydia treatment with reports of up to 22% failure following azithromycin. We will conduct a randomised trial to compare these treatments for rectal chlamydia and determine which drug works better.
A Population-based Record Linkage Study Of The Impact Of Chlamydia Infection On Reproductive Health In Women
Funder
National Health and Medical Research Council
Funding Amount
$405,114.00
Summary
Chlamydia is the most commonly notified infection in young Australian women and reports of cases are increasing. While chlamydia is thought to result in infertility and ectopic pregnancy in later life, the evidence for this is limited. This will be the largest, most comprehensive study in the world to determine the risk of infertility and ectopic pregnancy following chlamydia infection. The results will provide vital information to more cost-effectively plan strategies to control chlamydia in Au ....Chlamydia is the most commonly notified infection in young Australian women and reports of cases are increasing. While chlamydia is thought to result in infertility and ectopic pregnancy in later life, the evidence for this is limited. This will be the largest, most comprehensive study in the world to determine the risk of infertility and ectopic pregnancy following chlamydia infection. The results will provide vital information to more cost-effectively plan strategies to control chlamydia in Australia.Read moreRead less
PH-dependent, Antibody-mediated Enhancement Of Genital Chlamydial Infection: Implications For Vaccine Design ?
Funder
National Health and Medical Research Council
Funding Amount
$373,228.00
Summary
Antibody found in cervicovaginal secretions is predominantly of the IgG subclass. In the acidic environment of the female reproductive tract IgG antibodies against surface antigens on Chlamydia may actually enhance rather than prevent infection, due to uptake of IgG-coated bacteria by the neonatal Fc receptor (FcRn), which is found on the surface of epithelial cells in the reproductive tract. The proposed studies will determine the effects of chlamydial antibodies on the course of infection.
Evaluation Of Chlamydia Trachomatis Treatment Failure: A Cohort Study Of Women
Funder
National Health and Medical Research Council
Funding Amount
$761,844.00
Summary
Chlamydia is a very common sexually transmissible infection in Australia that can lead to infertility in women. About 4% of young adults have it. There is increasing concern by experts about the efficacy of the recommended chlamydia treatment. This is further supported by very high repeat infection rates following a previous positive chlamydia diagnosis. This study will measure whether chlamydia treatment failure is a problem and if so, this will change treatment guidelines worldwide.
A Randomised Controlled Trial To Evaluate The Effectiveness And Cost-effectiveness Of Chlamydia Testing In General Practice.
Funder
National Health and Medical Research Council
Funding Amount
$1,377,557.00
Summary
Chlamydia is a very common sexually transmissible infection in Australia that can lead to infertility in women. About 4% of young adults have it. Most people with chlamydia do not have any symptoms and will be unaware they have it. Chlamydia is easy to diagnose and treat, but it is not known whether regular testing can reduce its spread. We propose to conduct a trial to evaluate whether annual testing for 16 to 29 year olds works and whether it would be a good use of public health funds.