Dendritic Cell Function, Migration And Modulation In A Murine Model Of Inflammatory Arthritis
Funder
National Health and Medical Research Council
Funding Amount
$201,870.00
Summary
Rheumatoid arthritis (RA) is a debilitating disease that affects the joints and other tissues. While it can often be controlled with drugs, complete remission off treatment is rare. Dendritic cells are the educators of the immune system. By displaying antigen to T cells they communicate the response that the immune system should make to foreign organisms, tumors and to self. Therefore, a communication failure may result in chronic inflammation, tumor growth or autoimmune disease, such as RA. In ....Rheumatoid arthritis (RA) is a debilitating disease that affects the joints and other tissues. While it can often be controlled with drugs, complete remission off treatment is rare. Dendritic cells are the educators of the immune system. By displaying antigen to T cells they communicate the response that the immune system should make to foreign organisms, tumors and to self. Therefore, a communication failure may result in chronic inflammation, tumor growth or autoimmune disease, such as RA. In this proposal, we focus on the role of dendritic cells in a mouse model of RA and explore ways of using dendritic cells to turn off disease, that if successful may translate in humans to induction of remission.Read moreRead less
Group orbits in garmonic analysis and ergodic theory. Researchers from many areas need a type of mathematical analysis which involves the behaviour of a system - which may be a set of data points - under repeated application of some operation or group of operations. The structures arising from this kind of process are known as group orbits. The project gives information about their nature. Two major types of orbits are considered, coming from actions of discrete groups on measure spaces, and fro ....Group orbits in garmonic analysis and ergodic theory. Researchers from many areas need a type of mathematical analysis which involves the behaviour of a system - which may be a set of data points - under repeated application of some operation or group of operations. The structures arising from this kind of process are known as group orbits. The project gives information about their nature. Two major types of orbits are considered, coming from actions of discrete groups on measure spaces, and from smooth actions of Lie groups on manifolds, where powerful geometric methods are available. The project will yield new understandings of entropy, and new approaches to Fourier analysis.Read moreRead less
Ergodic theory and number theory. Recent advances in the theory of measured dynamical systems investigated by the proponents include new versions of entropy, and the study of spectral theory for non-singular systems. These will be further developed in this joint project with the French CNRS. The results are expected to have interesting applications in physics and number theory.
Operator Integrals and Derivatives. The project is a contribution to the study of non-commutative differential and integral calculus. The novelty of the present project lies in the study of smoothness properties of functions whose domains and ranges are spaces of unbounded, non-commuting operators on some Hilbert space. Our general approach will be based on a detailed investigation of properties of double operator integrals, which permit smoothness estimates of operator-functions. It can be expe ....Operator Integrals and Derivatives. The project is a contribution to the study of non-commutative differential and integral calculus. The novelty of the present project lies in the study of smoothness properties of functions whose domains and ranges are spaces of unbounded, non-commuting operators on some Hilbert space. Our general approach will be based on a detailed investigation of properties of double operator integrals, which permit smoothness estimates of operator-functions. It can be expected that the new techniques generated will find further application in areas of mathematical physics and non-commutative geometry related to quantized calculus.
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