Simulation, Modelling, Prediction and Two-Dimensional Retention Database Development in Comprehensive Two-Dimensional Gas Chromatography (GC×GC). Quality of life is enhanced by the application of chromatography to many aspects of living. It is an existing technology made more powerful when used as comprehensive two-dimensional gas chromatography (GC×GC), an advanced form of GC. This project will apply new interpretation strategies to GC×GC to improve precise chemical analysis in many areas inclu ....Simulation, Modelling, Prediction and Two-Dimensional Retention Database Development in Comprehensive Two-Dimensional Gas Chromatography (GC×GC). Quality of life is enhanced by the application of chromatography to many aspects of living. It is an existing technology made more powerful when used as comprehensive two-dimensional gas chromatography (GC×GC), an advanced form of GC. This project will apply new interpretation strategies to GC×GC to improve precise chemical analysis in many areas including: measurement of 'good fats' in foods, sources of illicit drugs, allergens in perfumes, disease profiling through metabolite monitoring and the detection of performance enhancing drugs in sport. Based on this research, the science of chromatography will be advanced in Australia and throughout the world, using Australian technology and expertise.Read moreRead less
Multivariate approaches to matching spectra for environmental and forensic purposes. Apart from an increased understanding of these commonly-used analytical methods, and their extension to current problems, the outcome of the project will be programs that can be used by the Environmental Protection Agency to give the probability that an oil spill comes from an alleged source. This evidence may be laid before a court, and is more objective than present methods. The identification of illegal drugs ....Multivariate approaches to matching spectra for environmental and forensic purposes. Apart from an increased understanding of these commonly-used analytical methods, and their extension to current problems, the outcome of the project will be programs that can be used by the Environmental Protection Agency to give the probability that an oil spill comes from an alleged source. This evidence may be laid before a court, and is more objective than present methods. The identification of illegal drugs will also be made possible, including information about the country or region of origin, and the place and processes used to refine the drug.Read moreRead less
A multi-metal ion sensor for analysis of environmental water. The aim of this research project is to develop an electrochemical sensor array on a single chip for the detection of several heavy metals in wastewater samples. Each electrode in the array will be modified with a different metal-binding peptide ligand; resulting in a characteristic response pattern for a given metal ion. Deconvolution of the sensor response into the response patterns of the individual metals will be achieved using p ....A multi-metal ion sensor for analysis of environmental water. The aim of this research project is to develop an electrochemical sensor array on a single chip for the detection of several heavy metals in wastewater samples. Each electrode in the array will be modified with a different metal-binding peptide ligand; resulting in a characteristic response pattern for a given metal ion. Deconvolution of the sensor response into the response patterns of the individual metals will be achieved using pattern recognition software employing artificial neural networks and other multivariate techniques. Successful development of the multi-analyte sensor will allow the rapid monitoring of environmentally important metal ions in the field.Read moreRead less
Assembly and Interactions of Helical Supramolecular Structures. The project in advanced materials is significant in probing an exciting topology in nanostructural assemblies - helicates - the understanding of the interactions of which will assist the development of optically pure molecules that are the key to high-value drugs, thus contributing to enhanced development in the specialty chemicals and pharmaceuticals industry. The research may result in economic benefits for Australia, since it wil ....Assembly and Interactions of Helical Supramolecular Structures. The project in advanced materials is significant in probing an exciting topology in nanostructural assemblies - helicates - the understanding of the interactions of which will assist the development of optically pure molecules that are the key to high-value drugs, thus contributing to enhanced development in the specialty chemicals and pharmaceuticals industry. The research may result in economic benefits for Australia, since it will develop synthetic materials with the potential to perform tasks in high optical purity essential drug synthesis. Further, it will enhance the knowledge and skills base within the country through training of highly applicable scientists for a growing national priority area. Read moreRead less
Olfactory Characterisation of Odours for Optimising Impact Assessment. The repeated release of obnoxious odours from intensive livestock, waste management and wastewater treatment facilities can constitute a major air quality problem for a local population. Odour management has traditionally been maintained by the use of buffer distances that have significantly decreased with urban encroachment. Odour assessment is conventionally measured in terms of odour concentration; however this standardise ....Olfactory Characterisation of Odours for Optimising Impact Assessment. The repeated release of obnoxious odours from intensive livestock, waste management and wastewater treatment facilities can constitute a major air quality problem for a local population. Odour management has traditionally been maintained by the use of buffer distances that have significantly decreased with urban encroachment. Odour assessment is conventionally measured in terms of odour concentration; however this standardised method does not take into account odour quality characters or their intensity. The project will characterise by sensory means the odour nuisance types and intensity of different odorous emissions to better define and understand the relationship between process operations and olfactory annoyance.Read moreRead less
Prediction of fruit quality by non-invasive assessment, with special reference to avocado. The project aims to develop non-invasive rapid assessment techniques of avocado quality (dry matter percentage, oil content, susceptibility to rots) suitable for application in at-line, in-line and in-field settings using NIR spectroscopic methods. The development and introduction of these non-invasive technologies into the avocado industry will allow rapid low-cost testing to support existing quality con ....Prediction of fruit quality by non-invasive assessment, with special reference to avocado. The project aims to develop non-invasive rapid assessment techniques of avocado quality (dry matter percentage, oil content, susceptibility to rots) suitable for application in at-line, in-line and in-field settings using NIR spectroscopic methods. The development and introduction of these non-invasive technologies into the avocado industry will allow rapid low-cost testing to support existing quality control procedures. The technology has the potential to enhance the competitive advantage of Australian producers/processors by guaranteeing high quality and optimising shelf-life. The ability to deliver a differentiated product will maximise sales in existing markets and facilitate the targeting of new domestic and overseas markets.Read moreRead less
Maximum entropy methods for Bayesian analysis in chemistry. This new approach for analysing chemical data will solve problems in deciding the weight of an atom in a chemical compound, whether an athlete took illegal steroids, if a horse has been fed an illegal 'milkshake' of bicarbonate, and if a methamphetamine tablet seized in a nightclub was made from powder found in a clandestine lab.
Identification and isolation of new pharmaceutical opiate analogues: today's problems tomorrow's solutions. This project will identify and characterise the impurity profiles across opiate alkaloid production, which will enhance the development of manufacturing processes through the reduction of problem impurities and provide potential new drug substances from the isolation of other opiate derived concomitant species.
Ochre archaeomicrobiology: a new tool for understanding Aboriginal exchange. This project aims to identify the origins and movements of Australian archaeological ochre through the development of a novel tool combining genomic and chemical analysis. The geographic distribution of Australian ochre is closely linked to Aboriginal creation stories, while its physical distribution by people is evidence of cultural cooperation. Using this new archaeomicrobiological technique, the project aims to answe ....Ochre archaeomicrobiology: a new tool for understanding Aboriginal exchange. This project aims to identify the origins and movements of Australian archaeological ochre through the development of a novel tool combining genomic and chemical analysis. The geographic distribution of Australian ochre is closely linked to Aboriginal creation stories, while its physical distribution by people is evidence of cultural cooperation. Using this new archaeomicrobiological technique, the project aims to answer significant questions about past human behaviour, in terms of trade, cultural interactions, territoriality and colonisation. The method also has the potential to benefit traditional owners by contributing to repatriation projects. The collaborative detailed recording, sampling and analysis of ochre sources on traditional lands will also assist Aboriginal communities to manage this important aspect of their cultural heritage.Read moreRead less