Harnessing light and electricity to drive chemical synthesis. This project will explore and establish original strategies that use inputs of energy (light and electricity) to break or form chemical bonds, which can provide new or improved access to valuable compounds. In this way, this research will augment or enhance existing methods for the selective and direct manipulation of molecules by creating tools that allow chemists to prepare molecules under particularly mild conditions. The outcomes ....Harnessing light and electricity to drive chemical synthesis. This project will explore and establish original strategies that use inputs of energy (light and electricity) to break or form chemical bonds, which can provide new or improved access to valuable compounds. In this way, this research will augment or enhance existing methods for the selective and direct manipulation of molecules by creating tools that allow chemists to prepare molecules under particularly mild conditions. The outcomes of the project will include the development of new technology for organic synthesis and forging novel approaches for chemical alkylation and cross-coupling reactions. This can contribute to making important compounds more efficiently, safely and cheaper to produce in the future.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100949
Funder
Australian Research Council
Funding Amount
$425,364.00
Summary
Metal-free strategies for sustainable light-driven synthesis. Innovation in synthetic chemistry drives the discovery of new life-saving drugs, agrochemicals and functional materials. This project aims to use visible light to access underexploited reactive intermediates and harness their unique reactivity in new sustainable synthetic transformations. The new chemical processes are expected to deliver increased economy, efficiency and precision in the synthesis of bioactive molecules that are inac ....Metal-free strategies for sustainable light-driven synthesis. Innovation in synthetic chemistry drives the discovery of new life-saving drugs, agrochemicals and functional materials. This project aims to use visible light to access underexploited reactive intermediates and harness their unique reactivity in new sustainable synthetic transformations. The new chemical processes are expected to deliver increased economy, efficiency and precision in the synthesis of bioactive molecules that are inaccessible or challenging to prepare with existing technologies. The conceptual and practical outcomes of this project are expected to benefit both academia and industry as the use of hazardous and expensive metal catalysts can be avoided, reducing chemical waste and simplifying purification.Read moreRead less
Enhanced Synthetic Efficiency For Molecular Complexity and Diversity. This project aims to introduce new, broad-spectrum strategies that permit more efficient and selective ways to access complex organic molecules. The approach involves maximising the molecule-building potential of some of the smallest accessible molecular building blocks. Significant outcomes expected from this work include much shorter chemical syntheses of important organic substances and much improved, broad scope synthetic ....Enhanced Synthetic Efficiency For Molecular Complexity and Diversity. This project aims to introduce new, broad-spectrum strategies that permit more efficient and selective ways to access complex organic molecules. The approach involves maximising the molecule-building potential of some of the smallest accessible molecular building blocks. Significant outcomes expected from this work include much shorter chemical syntheses of important organic substances and much improved, broad scope synthetic methods. The concepts introduced by this work aims to benefit industry and manufacturing by introducing more efficient methods for fine chemical manufacture, while simultaneously lowering energy use and producing less waste.Read moreRead less
Hydrogen atom abstraction and addition via proton coupled electron transfer. To prepare new chemicals for the challenges of today, and those in the future, new ways to build materials are needed. These need to deliver maximum complexity (necessary for increasingly sophisticated applications) with minimal economic and environmental cost. In this proposal a family of reactions that are possible using light mediated chemistry will be developed. This approach will allow technologies to be discovered ....Hydrogen atom abstraction and addition via proton coupled electron transfer. To prepare new chemicals for the challenges of today, and those in the future, new ways to build materials are needed. These need to deliver maximum complexity (necessary for increasingly sophisticated applications) with minimal economic and environmental cost. In this proposal a family of reactions that are possible using light mediated chemistry will be developed. This approach will allow technologies to be discovered that will enhance the scientific communities ability to deliver materials designed for a wide array of functions from medicinal chemistry, through to materials science. Read moreRead less
Multi-Bond-Forming Processes: Step-Economical Synthesis In Batch And Flow. This project aims to develop better ways to make and understand organic substances: the materials that make up all known life forms, our medicines, and many designed materials. Based on the previous development of powerful multi-bond-forming processes, the purpose of this project is to develop cascade sequences involving dendralenes in new and innovative ways. The project plans to generalise these processes and apply them ....Multi-Bond-Forming Processes: Step-Economical Synthesis In Batch And Flow. This project aims to develop better ways to make and understand organic substances: the materials that make up all known life forms, our medicines, and many designed materials. Based on the previous development of powerful multi-bond-forming processes, the purpose of this project is to develop cascade sequences involving dendralenes in new and innovative ways. The project plans to generalise these processes and apply them in short total syntheses; extend the boundaries of multi-bond-forming processes and break new records; and reach higher levels of synthetic efficiency and selectivity by introducing the latest flow chemistry and automated reaction optimisation technology.Read moreRead less
Organic Linchpin Reagents to Construct Structural Diversity and Complexity. High-energy chemical species such as carbenes, nitrenes or free radicals are often used as reactive intermediates in organic reactions to rapidly generate new bonds, structures and structural complexities. Due to their reactive nature, traditionally only one type of high-energy chemical species can be featured at a time to avoid unwanted complicated side reactions. This project aims to develop novel synthetic substrates ....Organic Linchpin Reagents to Construct Structural Diversity and Complexity. High-energy chemical species such as carbenes, nitrenes or free radicals are often used as reactive intermediates in organic reactions to rapidly generate new bonds, structures and structural complexities. Due to their reactive nature, traditionally only one type of high-energy chemical species can be featured at a time to avoid unwanted complicated side reactions. This project aims to develop novel synthetic substrates bearing multiple carbene and nitrene precursors of different types. These high-energy intermediates can be released in a relayed fashion by controlling orthogonal stimuli and therefore acting as linchpin reagents for quick construction of bio- or photo-active compounds and unprecedented complicated structures.Read moreRead less
New catalytic alkyne cyclisation strategies for complex molecule synthesis. This project aims to realise new and efficient catalytic chemistry for carbocyclic and heterocyclic synthesis, an immensely important compound family due to their synthetic, biological and material applications. This would be shown by providing new sustainable solutions that minimise resources use and waste production urgently demanded by industry and society to lessen the ecological impact of chemical manufacturing. Exp ....New catalytic alkyne cyclisation strategies for complex molecule synthesis. This project aims to realise new and efficient catalytic chemistry for carbocyclic and heterocyclic synthesis, an immensely important compound family due to their synthetic, biological and material applications. This would be shown by providing new sustainable solutions that minimise resources use and waste production urgently demanded by industry and society to lessen the ecological impact of chemical manufacturing. Expected outcomes include new materials and chemical processes giving Australian industry and academia the cutting-edge in research competitiveness and capacity. This should provide major benefits such as training the next generation of Australian synthetic chemists and wealth creation by supporting the chemical sciences.Read moreRead less
Photoinduced Palladium Catalysis for Next Generation C-H Bond Activation. This project aims to discover new methods for the conversion of carbon-hydrogen bonds in organic molecules as a general strategy in chemical synthesis. A key conceptual advance in this project is the unification of transition metal catalysis and visible light as a powerful tool to activate these traditionally unreactive, yet abundant chemical bonds in alkanes. With application in fields that range from fine chemical produc ....Photoinduced Palladium Catalysis for Next Generation C-H Bond Activation. This project aims to discover new methods for the conversion of carbon-hydrogen bonds in organic molecules as a general strategy in chemical synthesis. A key conceptual advance in this project is the unification of transition metal catalysis and visible light as a powerful tool to activate these traditionally unreactive, yet abundant chemical bonds in alkanes. With application in fields that range from fine chemical production to drug discovery, the overarching aim of this research is to establish new carbon-hydrogen bond activation reactions and to demonstrate that this strategy can be translated to the invention of new pharmaceuticals, agrochemicals and advanced synthetic materials that will have societal impact.Read moreRead less
Next Generation Photocatalysis for Chemical Synthesis and Manufacture. This project aims to discover new methods for the activation of energy demanding bonds in organic molecules as a general strategy in chemical synthesis. A key conceptual advance in this project is the development of multiphoton photoredox catalysis as a powerful tool to activate traditionally unreactive, yet abundant chemical bonds in organic molecules including C-H bonds in alkane and olefin feedstocks. With application in f ....Next Generation Photocatalysis for Chemical Synthesis and Manufacture. This project aims to discover new methods for the activation of energy demanding bonds in organic molecules as a general strategy in chemical synthesis. A key conceptual advance in this project is the development of multiphoton photoredox catalysis as a powerful tool to activate traditionally unreactive, yet abundant chemical bonds in organic molecules including C-H bonds in alkane and olefin feedstocks. With application in fields that range from fine chemical production to drug discovery, the overarching aim of this research is to establish new bond activation reactions and to demonstrate translations to the invention of new pharmaceuticals, agrochemicals and advanced chemical manufacturing processes that will have societal impact.Read moreRead less
Correlative Imaging of Brain Lipids. This project aims to develop imaging tools and protocols for the detection of lipids in brain tissue and cells. This project expects to generate advanced methodologies to display specific lipid classes and their corresponding structures within tissues and cells, with the ability to be detected and correlated with multiple techniques, which represent a currently unavailable capacity. The expected outcomes of this project are improved opportunities to study lip ....Correlative Imaging of Brain Lipids. This project aims to develop imaging tools and protocols for the detection of lipids in brain tissue and cells. This project expects to generate advanced methodologies to display specific lipid classes and their corresponding structures within tissues and cells, with the ability to be detected and correlated with multiple techniques, which represent a currently unavailable capacity. The expected outcomes of this project are improved opportunities to study lipid biology at the cellular and sub-cellular level across a wide range of in vitro and in vivo models. The outcomes of this project should provide significant knowledge to tackle modern societal challenges in healthy ageing, brain pathologies and neurodegenerative diseases.Read moreRead less