Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989539
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
Purchase of a state-of-the-art high resolution inductively coupled plasma mass spectrometer. This new state-of-the-art mass spectrometer with enhanced capability will allow Tasmanian researchers to accurately determine the elemental composition of their samples of interest. The instrument will be extremely sensitive and will be able to detect elements to very low concentrations. It will be used to support a diverse range of local research projects of international significance, for example the ....Purchase of a state-of-the-art high resolution inductively coupled plasma mass spectrometer. This new state-of-the-art mass spectrometer with enhanced capability will allow Tasmanian researchers to accurately determine the elemental composition of their samples of interest. The instrument will be extremely sensitive and will be able to detect elements to very low concentrations. It will be used to support a diverse range of local research projects of international significance, for example the environmental assessment of clean and contaminated sites, chemical synthesis on a miniature scale using micro-chips, and the monitoring of selected elements of key importance for human health.Read moreRead less
Advanced micro analysis systems for environmental monitoring. Understanding of the behaviour of the nutrients controlling nuisance algae in water bodies is currently limited by the cost and logistics of collecting and analysing the large numbers of samples required.
This proposal describes the development and evaluation of portable multiparameter micro analysis systems that will be capable of high frequency measurements from a sampling vessel. This will enable environmental agencies to perfo ....Advanced micro analysis systems for environmental monitoring. Understanding of the behaviour of the nutrients controlling nuisance algae in water bodies is currently limited by the cost and logistics of collecting and analysing the large numbers of samples required.
This proposal describes the development and evaluation of portable multiparameter micro analysis systems that will be capable of high frequency measurements from a sampling vessel. This will enable environmental agencies to perform rapid on-site mapping of nutrients and other water quality parameters in large water bodies, intensive scale mapping of effluent mixing and dispersal zones, quick assessment of the impact of dredging and aquaculture, and compliance monitoring in effluent streams.
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Targeting organically-complexed iron species in seawater using selective solid-phase adsorbent resins. Iron limits primary productivity in 40% of the oceans. Its accurate determination is thus critical to understanding the functioning of marine ecosystems and their role in moderating Earth's climate. Recent findings indicate that serious discrepancies exist in iron concentrations obtained using different analytical methods. These discrepancies are believed to be due to the lability of organic ....Targeting organically-complexed iron species in seawater using selective solid-phase adsorbent resins. Iron limits primary productivity in 40% of the oceans. Its accurate determination is thus critical to understanding the functioning of marine ecosystems and their role in moderating Earth's climate. Recent findings indicate that serious discrepancies exist in iron concentrations obtained using different analytical methods. These discrepancies are believed to be due to the lability of organic and colloidal iron species to extraction by adsorbent preconcentration resins. This project will design and synthesise a range of functionalised resins for the selective extraction of iron species from seawater, advancing our knowledge of its bioavailability and leading to the generation of class-specific analytical methodologies.Read moreRead less
The Synthesis and Analysis of Certain Explosives and Illicit Drugs for Improved Forensic Detection. There is an increasing demand within law enforcement agencies, worldwide, for selective and sensitive methods for the determination of illicit substances. Over the last decade Deakin University chemists have played a major role in establishing the utility of chemiluminescent reactions for the determination of a variety of pharmaceutical opiates in process streams. This project seeks to build upon ....The Synthesis and Analysis of Certain Explosives and Illicit Drugs for Improved Forensic Detection. There is an increasing demand within law enforcement agencies, worldwide, for selective and sensitive methods for the determination of illicit substances. Over the last decade Deakin University chemists have played a major role in establishing the utility of chemiluminescent reactions for the determination of a variety of pharmaceutical opiates in process streams. This project seeks to build upon these successes, in order to develop innovative analytical strategies for forensic detection of certain illicit drugs and explosives. The results of this research have the potential to revolutionise key aspects of forensic analysis.Read moreRead less
New Enantiomeric Separation Technologies for Natural Product, Pharmaceuticals and Environmental Pollutant Characterisation. Enantiomeric characterisation allows evaluation of drug purity for potentially harmful constituents, consumer protection against adulteration of essential oils and natural materials, and study of chemical interactions in biochemical/environmental systems. Chromatograph technologies (GC, HPLC and CE)for enantioseparation are available, however limitations prevent multicompon ....New Enantiomeric Separation Technologies for Natural Product, Pharmaceuticals and Environmental Pollutant Characterisation. Enantiomeric characterisation allows evaluation of drug purity for potentially harmful constituents, consumer protection against adulteration of essential oils and natural materials, and study of chemical interactions in biochemical/environmental systems. Chromatograph technologies (GC, HPLC and CE)for enantioseparation are available, however limitations prevent multicomponent characterisation of complete sample mixtures. Critical choices involve: choosing a chiral selector that interacts differentially upon all enantiomers; incorporation of selector into high-efficiency chromatographic systems; application to all target compounds in the sample. We will synthesise novel chiral selectors, incorporate these into new separation columns, apply ultra-high resolution 2-dimensional GCxGC to broad-spectrum chiral analysis of volatile chemical samples.Read moreRead less
Integrated Multidimensional Gas Chromatography - Spectroscopic Detection Methodology for Chemical Marker Discovery. Chemical species are pervasive in our modern society and are found in personal care products, foods, additives, petroleum products, illicit drugs, pharmaceuticals and pollutants. Each sample must be analysed to determine its accurate composition, and as a safeguard. This requires chemical methods of analysis. Classical chemical methods may fail when samples become too complex, or t ....Integrated Multidimensional Gas Chromatography - Spectroscopic Detection Methodology for Chemical Marker Discovery. Chemical species are pervasive in our modern society and are found in personal care products, foods, additives, petroleum products, illicit drugs, pharmaceuticals and pollutants. Each sample must be analysed to determine its accurate composition, and as a safeguard. This requires chemical methods of analysis. Classical chemical methods may fail when samples become too complex, or they may lead to imprecise identification. This Frontier Technologies proposal has broad national and international relevance through development of new methods for authentication of chemical identity and the subsequent superior ability to characterise numerous sample compositions.Read moreRead less
Bioanalytical Microchips Based on Integrated, Application Tailored Monolithic Modules. Microfluidic devices offer substantial advantages over current technology, in terms of speed, cost of analysis, portability, operator simplicity and safety. Integrating multiple analytical processes within a simple and reliable portable device will lead to application in a range of areas, from pharmacology to therapeutic drug monitoring, proteomic and metabolomic screening for disease diagnosis and drug develo ....Bioanalytical Microchips Based on Integrated, Application Tailored Monolithic Modules. Microfluidic devices offer substantial advantages over current technology, in terms of speed, cost of analysis, portability, operator simplicity and safety. Integrating multiple analytical processes within a simple and reliable portable device will lead to application in a range of areas, from pharmacology to therapeutic drug monitoring, proteomic and metabolomic screening for disease diagnosis and drug development, and also for performing clinical diagnostics in a rural area. This will significantly impact on the quality of life of the Nation as a whole, not only due to expedient diagnosis and treatment which has obvious health benefits, but also in the considerable financial benefits that result from early and efficient treatment. Read moreRead less
Multi-Colour Electrogenerated Chemiluminescence. This project plans to explore a new approach to chemical detection, in which molecules that emit different coloured light can be selectively switched on or switched off via the applied electrode potential. This would enable unprecedented numbers of simultaneous (multiplexed) detection events for time-critical analytical applications such as clinical diagnostics, environmental monitoring and biodefense assays. These assays could be performed on low ....Multi-Colour Electrogenerated Chemiluminescence. This project plans to explore a new approach to chemical detection, in which molecules that emit different coloured light can be selectively switched on or switched off via the applied electrode potential. This would enable unprecedented numbers of simultaneous (multiplexed) detection events for time-critical analytical applications such as clinical diagnostics, environmental monitoring and biodefense assays. These assays could be performed on low-cost microfluidic platforms operated by portable consumer devices such as mobile phones. Expected outcomes may provide new capabilities in rapid screening for disease biomarkers, environmental pollutants and bioterrorism agents, using simple, low-cost, portable instrumentation.Read moreRead less
Intelligent nanoparticles: Interactive tools to decode brain activity. This project aims to use nanoparticles and integrated nanoparticle devices to unravel causal relationships between molecular events and high-level brain activity. These devices, capable of real-time sensing and adaptive responses, could expose previously unmeasurable cellular events and establish their physiological effects. This is expected to reveal the complex dynamics in the living brain and advance neuroscience and analy ....Intelligent nanoparticles: Interactive tools to decode brain activity. This project aims to use nanoparticles and integrated nanoparticle devices to unravel causal relationships between molecular events and high-level brain activity. These devices, capable of real-time sensing and adaptive responses, could expose previously unmeasurable cellular events and establish their physiological effects. This is expected to reveal the complex dynamics in the living brain and advance neuroscience and analytical chemistry.Read moreRead less
New biosensing strategies based on bipolar electrochemiluminescence. Chemical analysis is a vital activity in our society, which is to a large extent confined to scientific laboratories and carried out with complex instrumentation. The breakthrough technology envisioned in this proposal will pave the way for simple, low-cost tests which can be used by non-scientists. The development of small, portable sensors for applications ranging from pollution monitoring to health testing, will enable ordi ....New biosensing strategies based on bipolar electrochemiluminescence. Chemical analysis is a vital activity in our society, which is to a large extent confined to scientific laboratories and carried out with complex instrumentation. The breakthrough technology envisioned in this proposal will pave the way for simple, low-cost tests which can be used by non-scientists. The development of small, portable sensors for applications ranging from pollution monitoring to health testing, will enable ordinary people to gain knowledge about the concentrations of molecular compounds in their environments and in themselves. This will stimulate economic and social benefits related to environmental testing and early disease diagnosis and generate new commercial opportunities for the Australian biotechnology industry.Read moreRead less